1921
Volume 95, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

A universal hepatitis B vaccination program for infants was adopted in Indonesia in 1997. Before its implementation, the prevalence of hepatitis B surface antigen (HBsAg)–positive individuals in the general population was approximately 5–10%. The study aimed to investigate the hepatitis B virus (HBV) serological status and molecular profile among children, 15 years after adoption of a universal infant vaccination program in Indonesia. According to the Local Health Office data in five areas, the percentages of children receiving three doses of hepatitis B vaccine are high (73.9–94.1%), whereas the birth dose coverage is less than 50%. Among 967 children in those areas, the seropositive rate of HBsAg in preschool- and school-aged children ranged from 2.1% to 4.2% and 0% to 5.9%, respectively. Of the 61 HBV DNA–positive samples, the predominant genotype/subtype was B/. Subtype was identified in genotype C for the first time in this population. Six samples (11.5%) had an amino acid substitution within the determinant of the gene region, and one sample had T140I that was suggested as a vaccine-escape mutant type. The low birth dose coverage and the presence of a vaccine-escape mutant might contribute to the endemicity of HBV infection among children in Indonesia.

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2016-09-07
2017-09-22
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References

  1. Suwignyo S, , 1996. Seroepidemiology of hepatitis B and C in Indonesia. Int Hepatol Commun 5: 3037.[Crossref]
  2. Khan M, Dong JJ, Acharya SK, Dhagwardorj Y, Abbas Z, Jafri W, Mulyono DH, Tozun N, Sarin SK, , 2004. Hepatology issues in Asia: perspective from regional leaders. J Gastroenterol Hepatol 19: S419S430.[Crossref]
  3. Creati M, Saleh A, Ruff TA, Stewart T, Otto B, Sutanto A, Clements CJ, , 2007. Implementing the birth dose of hepatitis B vaccine in rural Indonesia. Vaccine 25: 59855993.[Crossref]
  4. World Health Organization, Regional Office for Southeast Asia, 2013. Regional Strategy for the Prevention and Control of Viral Hepatitis. Available at: http://www.searo.who.int/entity/emerging_diseases/topics/CD_282.pdf. Accessed March 16, 2015.
  5. National Institute of Health Research and Development, Ministry of Health of the Republic Indonesia, 2008. Report on National Basic Health Research 2007. Available at: http://terbitan.litbang.depkes.go.id/penerbitan/index.php/blp/catalog/book/22. Accessed August 10, 2013.
  6. Carman WF, , 1997. The clinical significance of surface antigen variants of hepatitis B virus. J Viral Hep 4: 11S20S.[Crossref]
  7. Yamamoto K, Horikita M, Tsuda F, Itoh K, Akahane Y, Yotsumoto S, Okamoto H, Mikakawa Y, Mayumi M, , 1994. Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen. J Virol 68: 26712676.
  8. Hsu HY, Chang MH, Ni YH, Chen HL, , 2004. Survey of hepatitis B surface variant infection in children 15 years after a nationwide vaccination programe in Taiwan. Gut 53: 14991503.[Crossref]
  9. Okamoto H, Tsuda F, Sakugawa H, Satrosoewignjo RI, Imai M, Miyakawa Y, Mayumi M, , 1988. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol 69: 25752583.[Crossref]
  10. Kramvis A, Kew M, Francois G, , 2005. Hepatitis B genotypes. Vaccine 23: 24092423.[Crossref]
  11. Seeger C, Zoulim F, Mason WS, Knipe DM, Howley PM, , 2013. Hepadnaviruses. , eds. Fields Virology, 6th edition. Philadelphia, PA: Lippincott, Williams and Wilkins, 21852221.
  12. Tatematsu K, Tanaka Y, Kurbanov F, Sagauchi F, Mano S, Maeshiro T, Nakayoshi T, Wakuta M, Miyakawa Y, Mizokami M, , 2009. A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J. J Virol 83: 1053810547.[Crossref]
  13. Lusida MI, Nugrahaputra VE, Soetjipto Handayani R, Naganofujii M, Sasayama M, Utsumi T, Hotta H, , 2008. Novel subgentypes of hepatitis B virus genotype C and D in Papua, Indonesia. J Clin Microbiol 46: 21602166.[Crossref]
  14. Utsumi T, Yano Y, Lusida MI, Amin M, Soetjipto Hotta H, Hayashi Y, , 2010. Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia. Am J Trop Med Hyg 83: 189193.[Crossref]
  15. Mulyanto Depamede SN, Surayah K, Tsuda F, Ichiyama K, Takahashi M, Okamoto H, , 2009. A nationwide molecular epidemiological study on hepatitis B virus in Indonesia: identification of two novel subgenotypes, B8, C7. Arch Virol 154: 10471059.[Crossref]
  16. Juniastuti Lusida MI, Nugrahaputra VE, Amin M, Utsumi T, Hayashi Y, Hotta H, , 2011. Another novel subgenotype of hepatitis B virus genotype C from Papuans of Highland origin. J Med Virol 83: 225234.[Crossref]
  17. Magnius LO, Norder H, , 1995. Subtype, genotype and molecular epidemiology of the hepatitis B virus as reflected by sequence variability of the S gene. Intervirology 38: 2434.
  18. Norder H, Courouce AM, Coursaget P, Echevaria JM, Lee SD, Mushahwar IK, Robertson BH, Locarnini S, Magnius LO, , 2004. Genetic diversity of hepatitis B virus strains derived worldwide: genotype, subgenotypes, HBsAg subtypes. Intervirology 47: 289309.[Crossref]
  19. Purdy MA, Talekar G, Swenson P, Araujo A, Fields H, , 2007. A new algorithm for deduction of hepatitis B surface antigen subtype determinants from the amino acid sequence. Intervirology 50: 4551.[Crossref]
  20. Mulyanto Tsuda F, Karossi AT, Soewignyo S, Roestamsjah Sumarsidi D, Trisnamurti RH, Sumardi Surayah Udin LZ, Wikanta M, Kanai K, Mishiro S, , 1997. Distribution of the hepatitis B virus in Indonesia: implication for heterogeneity and infection control measures. Arch Virol 142: 21212129.[Crossref]
  21. Zuckerman AJ, Zuckeman JN, , 1999. Molecular epidemiology of hepatitis B virus mutant. J Med Virol 58: 193195.[Crossref]
  22. Zuckerman AJ, , 2000. Effect of hepatitis B virus mutants on efficacy of vaccination. Lancet 355: 13821384.[Crossref]
  23. Francois G, Kew M, van Damme P, Mphahlele MJ, Mehews A, , 2001. Mutant hepatitis B viruses: a matter of academic interest only or a problem with far reaching implications? Vaccine 19: 37993815.[Crossref]
  24. Arauz-Ruiz P, Norder H, Visona KA, Magnius LO, , 1997. Molecular epidemiology of hepatitis B virus in Central America reflected in the genetic variability of the small S gene. J Infect Dis 176: 851858.[Crossref]
  25. Norder H, Courouce AM, Magnius LO, , 1994. Complete genome, phylogenetic relatedness and structural protein of six strains of hepatitis B virus, four of which represent two new genotypes. Virology 198: 489503.[Crossref]
  26. Nelson CM, Wibisono H, Purwanto H, Mansyur I, Moniaga V, Widjaya A, , 2004. Hepatitis B vaccine freezing in Indonesia cold chain: evidence and solutions. Bull World Health Organ 82: 99105.
  27. Levin CE, Nelson CM, Widjaya A, Moniaga V, Anwar C, , 2004. The costs of home delivery of a birth dose of hepatitis B vaccine in prefilled syringe in Indonesia. Bull World Health Organ 83: 456461.
  28. Clements CJ, Baoping Y, Crouch A, Hipgrave D, Mansoor O, Nelson CB, Treleaven S, Konkelenberg RV, Wirsma S, , 2006. Progress in the control of hepatitis B infection in the Western Pacific Region. Vaccine 24: 19751982.[Crossref]
  29. Ruff TA, Gertig D, Otto BF, Gust ID, Sutanto A, Soewarso TI, Kandun N, Marschner IC, Maynard JE, , 1995. Lombok hepatitis B model immunization project: toward universal infant hepatitis B immunization in Indonesia. J Infect Dis 171: 290296.[Crossref]
  30. Chan CY, Lee SD, Lo KJ, , 2004. Legend of hepatitis B vaccination: the Taiwan experience. J Gastroenterol Hepatol 19: 121126.[Crossref]
  31. Chen DS, , 2009. Hepatitis B vaccination: the key towards elimination and eradication of Hepatitis B. J Hepatol 50: 805816.[Crossref]
  32. Hipgrave DB, Maynard JE, Beverley AB, , 2006. Improving birth dose coverage of hepatitis B vaccine. Bull World Health Organ 84: 6571.[Crossref]
  33. Greenberg DP, , 1993. Pediatric experience with recombinant hepatitis B vaccine in infants and relevant safety and immunogenicity studies. Pediatr Infect Dis J 12: 438445.[Crossref]
  34. Otto BF, Suarnawa IM, Stewart T, Nelson C, Ruff TA, Widjaya A, Maynard JE, , 2000. At birth immunization against hepatitis B using novel pre-filled immunization device stored outside the cold chain. Vaccine 18: 498502.[Crossref]
  35. Cui F, Li L, Hadler SC, Wang F, Zheng H, Chen Y, Gong X, Hutin YJ, Cairns KL, Liang X, Yang W, , 2010. Factors associated with effectiveness of the first dose of vaccine in China: 1992–2005. Vaccine 28: 59735978.[Crossref]
  36. Ministry of Health of the Republic Indonesia, 2004. National Guideline of Vaccination Implementation. Available at: http://www.hukor.depkes.go.id. Accessed August 20, 2012.
  37. World Health Organization, 2013. Global Policy Report on the Prevention and Control of Viral Hepatitis. Available at: http://www.who.int/csr/disease/hepatitis/global_report/en/. Accessed March 16, 2015.
  38. National Center for Statistics of the Republic Indonesia, 2010. Life Time Migration: 1971–2010. Available at: http://www.bps.go.id/linkTableDinamis/view/id/855. Accessed October 27, 2015.
  39. Arauz-Ruiz P, Norder H, Robertson BH, Magnius LO, , 2002. Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J Gen Virol 83: 20592073.[Crossref]
  40. Okamoto H, Imai M, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M, , 1987. Point mutation in the S gene of hepatitis B virus for a d/y or w/r subtypic change in the two blood donors carrying a surface antigen of compound subtype adyr or adwr. J Virol 61: 30303034.
  41. Norder H, Courouce AM, Magnius LO, , 1992. Molecular basis of hepatitis B virus serotype variations within the four major subtypes. J Gen Virol 73: 31413145.[Crossref]
  42. Waters JA, O'Rourke SM, Richardson SC, Papavengelou G, Thomas HC, , 1987. Quantitative analysis of the humoral immune response to the “a” determinant of HBs antigen after inoculation with plasma derived or recombinant vaccine. J Med Virol 21: 155160.[Crossref]
  43. Carman WF, Van Deursen FJ, Mimms LT, Hardie D, Coppola R, Decker R, Sanders R, , 1997. The prevalence of surface antigen variants of hepatitis B virus in Papua New Guinea, South Africa and Sardinia. Hepatology 26: 16581666.[Crossref]
  44. Carman WF, Zanetti AR, Karayiannis P, Waters J, Manzillo G, Tanzi E, Zuckerman AJ, Thomas HC, , 1990. Vaccine induced escape mutant of hepatitis B virus. Lancet 336: 325329.[Crossref]
  45. Coleman PF, , 2006. Detecting hepatitis B surface antigen mutants. Emerg Infect Dis 12: 198203.[Crossref]
  46. Horvat RT, , 2011. Diagnostic and clinical relevance of HBV mutations. LabMedicine 42: 488496.
  47. Hsu HY, Chang MH, Liaw SH, Ni YH, Chen HL, , 1999. Changes of hepatitis B surface antigen variants in carrier children before and after vaccination in Taiwan. Hepatology 30: 13121317.[Crossref]
  48. Gerin JL, Alexander H, Shih JW, Purcell RH, Dapolito G, Engle R, Green N, Sutcliffe JG, Shinnick TM, Lerner RA, , 1983. Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induced subtype-specific antibodies in chimpanzees. Proc Natl Acad Sci USA 80: 23652369.[Crossref]
  49. Song BC, Kim SH, Kim H, Ying YH, Kim HJ, Kim YJ, Yoon JH, Lee HS, Cha CY, Kook YH, Kim BJ, , 2005. Prevalence of naturally occurring surface antigen variants of hepatitis B virus in Korea patients infected chronically. J Med Virol 76: 194202.[Crossref]
  50. Thedja MD, Roni M, Harahap AR, Siregar NC, Ie SI, Muljono DH, , 2010. Occult hepatitis B in blood donors in Indonesia: altered antigenicity of the hepatitis B virus surface protein. Hepatol Int 4: 608614.[Crossref]
  51. Utsumi T, Lusida MI, Yano Y, Purwono PB, Amin M, Soetjipto Hotta H, Hayashi Y, , 2014. Progress in the control of hepatitis B virus infection among children in Indonesia. J Vaccines Vaccin 5: 247.
  52. Ie SI, Thedja MD, Roni M, Muljono DH, , 2010. Prediction of conformational changes by single mutation in the hepatitis B virus surface antigen (HBsAg) identified in HBsAg-negative blood donors. Virol J 7: 326.[Crossref]
  53. Scheiblauer H, El Nageh M, Diaz S, Nick S, Zeichhardt H, Grunert HP, Prince A, , 2010. Performance evaluation of 70 hepatitis B virus (HBV) surface antigen (HBsAg) assays from around the world by a geographically diverse panel with an array of HBV genotypes and HBsAg subtypes. Vox Sang 98: 403414.[Crossref]
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  • Received : 10 Feb 2015
  • Accepted : 12 Apr 2016

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