Volume 93, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Blood–brain barrier (BBB) function and cerebrospinal fluid (CSF) biomarkers were measured in patients admitted to hospital with severe neurological infections in the Lao People's Democratic Republic ( = 66), including bacterial meningitis (BM; = 9) or tuberculosis meningitis (TBM; = 11), Japanese encephalitis virus (JEV; = 25), and rickettsial infections ( = 21) including murine and scrub typhus patients. The albumin index (AI) and glial fibrillary acidic protein (GFAP) levels were significantly higher in BM and TBM than other diseases but were also raised in individual rickettsial patients. Total tau protein was significantly raised in the CSF of JEV patients. No differences were found between clinical or neurological symptoms, AI, or biomarker levels that allowed distinction between severe neurological involvement by compared with species.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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  • Received : 10 Feb 2015
  • Accepted : 29 Mar 2015

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