Volume 93, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Blood–brain barrier (BBB) function and cerebrospinal fluid (CSF) biomarkers were measured in patients admitted to hospital with severe neurological infections in the Lao People's Democratic Republic ( = 66), including bacterial meningitis (BM; = 9) or tuberculosis meningitis (TBM; = 11), Japanese encephalitis virus (JEV; = 25), and rickettsial infections ( = 21) including murine and scrub typhus patients. The albumin index (AI) and glial fibrillary acidic protein (GFAP) levels were significantly higher in BM and TBM than other diseases but were also raised in individual rickettsial patients. Total tau protein was significantly raised in the CSF of JEV patients. No differences were found between clinical or neurological symptoms, AI, or biomarker levels that allowed distinction between severe neurological involvement by compared with species.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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  1. Ramakrishnan M, Ulland AJ, Steinhardt LC, Moisi JC, Were F, Levine OS, , 2009. Sequelae due to bacterial meningitis among African children: a systematic literature review. BMC Med 7: 47.[Crossref] [Google Scholar]
  2. Taylor WR, Nguyen K, Nguyen D, Nguyen H, Horby P, Nguyen HL, Lien T, Tran G, Tran N, Nguyen HM, Nguyen T, Nguyen HH, Nguyen T, Tran G, Farrar J, de Jong M, Schultsz C, Tran H, Nguyen D, Vu B, Le H, Dao T, Nguyen T, Wertheim H, , 2012. The spectrum of central nervous system infections in an adult referral hospital in Hanoi, Vietnam. PLoS One 7: e42099.[Crossref] [Google Scholar]
  3. Dittrich S, Rattanavong S, Lee SJ, Panyanivong P, Craig SB, Tulsiani SM, Blacksell SD, Dance DA, Dubot-Peres A, Sengduangphachanh A, Phoumin P, Paris DH, Newton PN, , 2015. Orientia, Rickettsia, and Leptospira pathogens as causes of CNS infections in Laos: a prospective study. Lancet Glob Health 3: e104e112.[Crossref] [Google Scholar]
  4. Nilsson K, Wallmenius K, Hartwig S, Norlander T, Pahlson C, , 2013. Bell's palsy and sudden deafness associated with Rickettsia spp. infection in Sweden. A retrospective and prospective serological survey including PCR findings. Eur J Neurol 21: 206214.[Crossref] [Google Scholar]
  5. Sayen JJ, Pond HS, Forrester JS, Wood FC, , 1946. Scrub typhus in Assam and Burma; a clinical study of 616 cases. Medicine (Baltimore) 25: 155214.[Crossref] [Google Scholar]
  6. Pai H, Sohn S, Seong Y, Kee S, Chang WH, Choe KW, , 1997. Central nervous system involvement in patients with scrub typhus. Clin Infect Dis 24: 436440.[Crossref] [Google Scholar]
  7. Kim DM, Chung JH, Yun NR, Kim SW, Lee JY, Han MA, Lee YB, , 2013. Scrub typhus meningitis or meningoencephalitis. Am J Trop Med Hyg 89: 12061211.[Crossref] [Google Scholar]
  8. Viswanathan S, Muthu V, Iqbal N, Remalayam B, George T, , 2013. Scrub typhus meningitis in south India—a retrospective study. PLoS One 8: e66595.[Crossref] [Google Scholar]
  9. Moore CE, Blacksell SD, Taojaikong T, Jarman RG, Gibbons RV, Lee SJ, Chansamouth V, Thongpaseuth S, Mayxay M, Newton PN, , 2012. A prospective assessment of the accuracy of commercial IgM ELISAs in diagnosis of Japanese encephalitis virus infections in patients with suspected central nervous system infections in Laos. Am J Trop Med Hyg 87: 171178.[Crossref] [Google Scholar]
  10. Moron CG, Popov VL, Feng HM, Wear D, Walker DH, , 2001. Identification of the target cells of Orientia tsutsugamushi in human cases of scrub typhus. Mod Pathol 14: 752759.[Crossref] [Google Scholar]
  11. Brown HC, Chau TT, Mai NT, Day NP, Sinh DX, White NJ, Hien TT, Farrar J, Turner GD, , 2000. Blood-brain barrier function in cerebral malaria and CNS infections in Vietnam. Neurology 55: 104111.[Crossref] [Google Scholar]
  12. Peluso MJ, Meyerhoff DJ, Price RW, Peterson J, Lee E, Young AC, Walter R, Fuchs D, Brew BJ, Cinque P, Robertson K, Hagberg L, Zetterberg H, Gisslen M, Spudich S, , 2013. Cerebrospinal fluid and neuroimaging biomarker abnormalities suggest early neurological injury in a subset of individuals during primary HIV infection. J Infect Dis 207: 17031712.[Crossref] [Google Scholar]
  13. Moureau G, Ninove L, Izri A, Cook S, De Lamballerie X, Charrel RN, , 2010. Flavivirus RNA in phlebotomine sandflies. Vector Borne Zoonotic Dis 10: 195197.[Crossref] [Google Scholar]
  14. Petzold A, , 2007. CSF biomarkers for improved prognostic accuracy in acute CNS disease. Neurol Res 29: 691708.[Crossref] [Google Scholar]
  15. Brouns R, De Vil B, Cras P, De Surgeloose D, Mariën P, De Deyn PP, , 2010. Neurobiochemical markers of brain damage in cerebrospinal fluid of acute ischemic stroke patients. Clin Chem 56: 451458.[Crossref] [Google Scholar]
  16. Rosso SM, van Herpen E, Pijnenburg YA, Schoonenboom NS, Scheltens P, Heutink P, van Swieten JC, , 2003. Total tau and phosphorylated tau 181 levels in the cerebrospinal fluid of patients with frontotemporal dementia due to p301l and g272v tau mutations. Arch Neurol 60: 12091213.[Crossref] [Google Scholar]

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  • Received : 10 Feb 2015
  • Accepted : 29 Mar 2015
  • Published online : 05 Aug 2015

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