Volume 94, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We communicate a case of a middle-aged Brazilian patient with an unusual presentation of fourth ventricular neurocysticercosis: occurrence of two intraventricular cysts at different locations in the brain within 2 years and cognitive decline as the only neurological symptom. Neurocysticercosis was confirmed by magnetic resonance imaging, serology, histology, and genetic analysis. Neurocysticercosis should be considered as a differential diagnosis in cases with atypical neurologic or psychiatric symptoms, atypical neuroimaging and travel history. Especially, fourth ventricular cysts carry the risk of obstructive hydrocephalus and brainstem compression and therefore should be extirpated completely. If complete removal of the cystic structures cannot be proven in cases with surgically treated neurocysticercosis, anthelminthic therapy and thorough follow-up examinations should be conducted.


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  1. Levine MZ, Calderon JC, Wilkins PP, Lane WS, Asara JM, Hancock K, Gonzalez AE, Garcia HH, Gilman RH, Tsang VC, , 2004. Characterization, cloning, and expression of two diagnostic antigens for Taenia solium tapeworm infection. J Parasitol 90: 631638.[Crossref] [Google Scholar]
  2. Winkler AS, Blocher J, Auer H, Gotwald T, Matuja W, Schmutzhard E, , 2009. Epilepsy and neurocysticercosis in rural Tanzania—an imaging study. Epilepsia 50: 987993.[Crossref] [Google Scholar]
  3. Winkler AS, , 2012. Neurocysticercosis in sub-Saharan Africa: a review of prevalence, clinical characteristics, diagnosis, and management. Pathog Glob Health 106: 261274.[Crossref] [Google Scholar]
  4. Nash TE, Garcia HH, , 2011. Diagnosis and treatment of neurocysticercosis. Nat Rev Neurol 7: 584594.[Crossref] [Google Scholar]
  5. Takayanagui OM, Odashima NS, , 2006. Clinical aspects of neurocysticercosis. Parasitol Int 55 (Suppl): S111S115.[Crossref] [Google Scholar]
  6. Del Brutto OH, , 2012. Neurocysticercosis in western Europe: a re-emerging disease? Acta Neurol Belg 112: 335343.[Crossref] [Google Scholar]
  7. Fleury A, Escobar A, Fragoso G, Sciutto E, Larralde C, , 2010. Clinical heterogeneity of human neurocysticercosis results from complex interactions among parasite, host and environmental factors. Trans R Soc Trop Med Hyg 104: 243250.[Crossref] [Google Scholar]
  8. Takayanagui OM, Odashima NS, Bonato PS, Lima JE, Lanchote VL, , 2011. Medical management of neurocysticercosis. Expert Opin Pharmacother 12: 28452856.[Crossref] [Google Scholar]
  9. Winkler AS, Richter H, , 2015. Landscape Analysis: Management of Neurocysticercosis with Emphasis on Low- and Middle-Income Countries. Geneva, Switzerland: World Health Organization. Available at: http://apps.who.int/iris/bitstream/10665/152896/1/WHO_HTM_NTD_NZD_2015.05_eng.pdf. [Google Scholar]
  10. Sinha S, Sharma BS, , 2012. Intraventricular neurocysticercosis: a review of current status and management issues. Br J Neurosurg 26: 305309.[Crossref] [Google Scholar]
  11. Bergsneider M, Holly LT, Lee JH, King WA, Frazee JG, , 2000. Endoscopic management of cysticercal cysts within the lateral and third ventricles. J Neurosurg 92: 1423.[Crossref] [Google Scholar]
  12. Amelot A, Faillot T, , 2014. Hydrocephalus and neurocysticercosis: cases illustrative of three distinct mechanisms. J Clin Neurol 10: 363366.[Crossref] [Google Scholar]
  13. Cuetter AC, Andrews RJ, , 2002. Intraventricular neurocysticercosis: 18 consecutive patients and review of the literature. Neurosurg Focus 12: e5.[Crossref] [Google Scholar]
  14. Khade P, Lemos RS, Toussaint LG, , 2013. What is the utility of postoperative antihelminthic therapy after resection for intraventricular neurocysticercosis? World Neurosurg 79: 558567.[Crossref] [Google Scholar]
  15. Tsang VC, Brand JA, Boyer AE, , 1989. An enzyme-linked immunoelectrotransfer blot assay and glycoprotein antigens for diagnosing human cysticercosis (Taenia solium). J Infect Dis 159: 5059.[Crossref] [Google Scholar]
  16. Carabin H, Ndimubanzi PC, Budke CM, Nguyen H, Qian Y, Cowan LD, Stoner JA, Rainwater E, Dickey M, , 2011. Clinical manifestations associated with neurocysticercosis: a systematic review. PLoS Negl Trop Dis 5: e1152.[Crossref] [Google Scholar]
  17. Ramirez-Bermudez J, Higuera J, Sosa AL, Lopez-Meza E, Lopez-Gomez M, Corona T, , 2005. Is dementia reversible in patients with neurocysticercosis? J Neurol Neurosurg Psychiatry 76: 11641166.[Crossref] [Google Scholar]
  18. Rodrigues CL, de Andrade DC, Livramento JA, Machado LR, Abraham R, Massaroppe L, Lucato LT, Caramelli P, , 2012. Spectrum of cognitive impairment in neurocysticercosis: differences according to disease phase. Neurology 78: 861866.[Crossref] [Google Scholar]
  19. Ciampi de Andrade D, Rodrigues CL, Abraham R, Castro LH, Livramento JA, Machado LR, Leite CC, Caramelli P, , 2010. Cognitive impairment and dementia in neurocysticercosis: a cross-sectional controlled study. Neurology 74: 12881295.[Crossref] [Google Scholar]
  20. Forlenza OV, Filho AH, Nobrega JP, dos Ramos Machado L, de Barros NG, de Camargo CH, da Silva MF, , 1997. Psychiatric manifestations of neurocysticercosis: a study of 38 patients from a neurology clinic in Brazil. J Neurol Neurosurg Psychiatry 62: 612616.[Crossref] [Google Scholar]
  21. Kotha VK, , 2013. Migration of intraventricular neurocysticercus after ventriculostomy. Asian J Neurosurg 8: 5456.[Crossref] [Google Scholar]
  22. Schantz P, Singh G, Prabhakar S, , 2002. Taenia solium cysticercosis: an overview of global distribution and transmission. , eds. Taenia solium Cysticercosis: From Basic to Clinical Science. Chandigarh, India: CABI Pub., 6373.[Crossref] [Google Scholar]

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  • Received : 03 Feb 2015
  • Accepted : 09 Oct 2015
  • Published online : 06 Jan 2016

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