1921
Volume 93, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Monkeypox (MPX) is a zoonotic Orthopoxvirus infection endemic in central and western Africa. Human MPX cases occur in the central and northern regions of the Democratic Republic of the Congo (DRC), and this is the first report of confirmed MPX cases in the forested areas of North and South Kivu Provinces, with a detailed epidemiological investigation for one case. The location of each case is within areas predicted to be suitable for MPX virus transmission based on an ecological niche model. Phylogenetic analysis places these viruses in the Congo Basin clade.

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2015-10-07
2017-09-22
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References

  1. Di Giulio DB, Eckburg PB, , 2004. Human monkeypox: an emerging zoonosis. Lancet Infect Dis 4: 1525.
  2. Jezek Z, Szczeniowski M, Paluku KM, Mutombo M, , 1987. Human monkeypox: clinical features of 282 patients. J Infect Dis 156: 293298.
  3. Reynolds MG, Damon IK, , 2012. Outbreaks of human monkeypox after cessation of smallpox vaccination. Trends Microbiol 20: 8087.
  4. Rimoin AW, Kisalu N, Kebela-Ilunga B, Mukaba T, Wright LL, Formenty P, Wolfe ND, Shongo RL, Tshioko F, Okitolonda E, Muyembe JJ, Ryder R, Meyer H, , 2007. Endemic human monkeypox, Democratic Republic of Congo, 2001–2004. Emerg Infect Dis 13: 934937.
  5. Mutombo M, Arita I, Jezek Z, , 1983. Human monkeypox transmitted by a chimpanzee in a tropical rain-forest area of Zaire. Lancet 1: 735737.
  6. Kulesh DA, Baker RO, Loveless BM, Norwood D, Zwiers SH, Mucker E, Hartmann C, Herrera R, Miller D, Christensen D, Wasieloski LP, Jr Huggins J, Jahrling PB, , 2004. Smallpox and pan-orthopox virus detection by real-time 3′-minor groove binder TaqMan assays on the roche LightCycler and the Cepheid smart Cycler platforms. J Clin Microbiol 42: 601609.
  7. Li Y, Olson VA, Laue T, Laker MT, Damon IK, , 2006. Detection of monkeypox virus with real-time PCR assays. J Clin Virol 36: 194203.
  8. Li Y, Zhao H, Wilkins K, Hughes C, Damon IK, , 2010. Real-time PCR assays for the specific detection of monkeypox virus west African and Congo Basin strain DNA. J Virol Methods 169: 223227.
  9. Nakazawa Y, Emerson GL, Carroll DS, Zhao H, Li Y, Reynolds MG, Karem KL, Olson VA, Lash RR, Davidson WB, Smith SK, Levine RS, Regnery RL, Sammons SA, Frace MA, Mutasim EM, Karsani ME, Muntasir MO, Babiker AA, Opoka L, Chowdhary V, Damon IK, , 2013. Phylogenetic and ecologic perspectives of a monkeypox outbreak, southern Sudan, 2005. Emerg Infect Dis 19: 237245.
  10. Phillips SJ, Anderson RP, Schapire RE, , 2006. Maximum entropy modeling of species geographic distributions. Ecol Modell 190: 231259.
  11. Phillips SJ, Dudik M, Schapire RE, , 2004. A maximum entropy approach to species distribution modeling. Proceedings of the Twenty-First International Conference on Machine Learning. 655662.
  12. Huelsenbeck JP, Ronquist F, , 2001. MRBAYES: Bayesian inference of phylogenetic trees. Bioinformatics 17: 754755.
  13. Kearse M, Moir R, Wilson A, Stones-Havas S, Cheung M, Sturrock S, Buxton S, Cooper A, Markowitz S, Duran C, Thierer T, Ashton B, Meintjes P, Drummond A, , 2012. Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data. Bioinformatics 28: 16471649.
  14. Emerson GL, Li Y, Frace MA, Olsen-Rasmussen MA, Khristova ML, Govil D, Sammons SA, Regnery RL, Karem KL, Damon IK, Carroll DS, , 2009. The phylogenetics and ecology of the orthopoxviruses endemic to North America. PLoS One 4: e7666.
  15. UNHCR, The UN Refugee Agency, 2013. Emergency Response for the Situation in the Eastern Democratic Republic of the Congo.
  16. Reynolds MG, Emerson GL, Pukuta E, Karhemere S, Muyembe JJ, Bikindou A, McCollum AM, Moses C, Wilkins K, Zhao H, Damon IK, Karem KL, Li Y, Carroll DS, Mombouli JV, , 2013. Detection of human monkeypox in the Republic of the Congo following intensive community education. Am J Trop Med Hyg 88: 982985.
  17. Rimoin AW, Mulembakani PM, Johnston SC, Lloyd Smith JO, Kisalu NK, Kinkela TL, Blumberg S, Thomassen HA, Pike BL, Fair JN, Wolfe ND, Shongo RL, Graham BS, Formenty P, Okitolonda E, Hensley LE, Meyer H, Wright LL, Muyembe JJ, , 2010. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci USA 107: 1626216267.
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  • Received : 02 Feb 2015
  • Accepted : 31 Mar 2015

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