1921
Volume 93, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

While visiting Malaysia, a 22-year-old previously healthy Japanese man developed myalgia, headache, and fever, leading to a diagnosis of classical dengue fever. After improvement and returning to Japan after a five day hospitalization, he developed productive cough several days after defervescing from dengue. Computed tomography (CT) thorax scan showed multiple lung cavities. A sputum smear revealed leukocytes with phagocytized gram-positive cocci in clusters, and grew an isolate sensitive to semi-synthetic penicillin; he was treated successfully with ceftriaxone and cephalexin. This second reported case of pneumonia due to occurring after dengue fever, was associated both with nosocomial exposure and might have been associated with dengue-associated immunosuppression. Clinicians should pay systematic attention to bacterial pneumonia following dengue fever to establish whether such a connection is causally associated.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.15-0045
2015-11-04
2017-09-25
Loading full text...

Full text loading...

/deliver/fulltext/14761645/93/5/1055.html?itemId=/content/journals/10.4269/ajtmh.15-0045&mimeType=html&fmt=ahah

References

  1. World Health Organization. Dengue. Available at: http://www.who.int/mediacentre/factsheets/fs117/en/. Accessed December 7, 2014.
  2. Nagassar RP, Bridgelal-Nagassar RJ, McMorris N, Roye-Green KJ, , 2012. Staphylococcus aureus pneumonia and dengue virus co-infection and review of implications of coinfection. BMJ Case Rep 2012: pii:bcr0220125804.
  3. Lee IK, Liu JW, Yang KD, , 2005. Clinical characteristics and risk factors for concurrent bacteremia in adults with dengue hemorrhagic fever. Am J Trop Med Hyg 72: 221226.
  4. Chai LY, Lim PL, Lee CC, Hsu LY, Teoh YL, Lye DC, Krishnan P, Leo YS, , 2007. Cluster of Staphylococcus aureus and dengue co-infection in Singapore. Ann Acad Med Singapore 36: 847850.
  5. Araújo SA, Moreira DR, Veloso JM, Silva JO, Barros VL, Nobre V, , 2010. Fatal Staphylococcal infection following classic dengue fever. Am J Trop Med Hyg 83: 679682.[Crossref]
  6. Sunderalingam V, Kanapathipillai T, Edirisinghe PA, Dassanayake KM, Premawansa IH, , 2013. Dengue viral myositis complicated with rhabdomyolysis and superinfection of methicillin-resistant Staphylococcus aureus . Case Rep Infect Dis 2013: 194205.
  7. Carney WP, Hirsch MS, , 1981. Mechanisms of immunosuppression in cytomegalovirus mononucleosis. II. Virus-monocyte interactions. J Infect Dis 144: 4754.[Crossref]
  8. Rouse BT, Horohov DW, , 1986. Immunosuppression in viral infections. Rev Infect Dis 8: 850873.[Crossref]
  9. Ho LJ, Hung LF, Weng CY, Wu WL, Chou P, Lin YL, Chang DM, Tai TY, Lai JH, , 2005. Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell. J Immunol 174: 81638172.[Crossref]
  10. Chase AJ, Medina FA, Muñoz-Jordán JL, , 2011. Impairment of CD4+ T cell polarization by dengue virus-infected dendritic cells. J Infect Dis 203: 17631774.[Crossref]
  11. Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, Viramitrachai W, Ratanachu-eke S, Kiatpolpoj S, Innis BL, Rothman AL, Nisalak A, Ennis FA, , 1997. Early clinical and laboratory indicators of acute dengue illness. J Infect Dis 176: 313321.[Crossref]
  12. La Russa VF, Innis BL, , 1995. Mechanisms of dengue virus-induced bone marrow suppression. Baillieres Clin Haematol 8: 249270.[Crossref]
  13. Lee YR, Su CY, Chow NH, Lai WW, Lei HY, Chang CL, Chang TY, Chen SH, Lin YS, Yeh TM, Liu HS, , 2007. Dengue viruses can infect human primary lung epithelia as well as lung carcinoma cells, and can also induce the secretion of IL-6 and RANTES. Virus Res 126: 216225.[Crossref]
  14. Hsu YL, Shi SF, Wu WL, Ho LJ, Lai JH, , 2013. Protective roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in dengue virus infection of human lung epithelial cells. PLoS One 8: e79518.[Crossref]
  15. Carratalà J, Mykietiuk A, Fernández-Sabé N, Suárez C, Dorca J, Verdaguer R, Manresa F, Gudiol F, , 2007. Health care-associated pneumonia requiring hospital admission: epidemiology, antibiotic therapy, and clinical outcomes. Arch Intern Med 167: 13931999.[Crossref]
  16. Sopena N, Sabrià M, Neunos 2000 Study Group, , 2005. Multicenter study of hospital-acquired pneumonia in non-ICU patients. Chest 127: 213219.[Crossref]
  17. Kallen AJ, Brunkard J, Moore Z, Budge P, Arnold KE, Fosheim G, Finelli L, Beekmann SE, Polgreen PM, Gorwitz R, Hageman J, , 2006. Staphylococcus aureus community-acquired pneumonia during the 2006 to 2007 influenza season. Ann Emerg Med 53: 358365.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.15-0045
Loading
/content/journals/10.4269/ajtmh.15-0045
Loading

Data & Media loading...

  • Received : 19 Jan 2015
  • Accepted : 06 Jul 2015

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error