International Centers of Excellence for Malaria Research: Background, Progress, and Ongoing Activities
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Understanding the epidemiological features and metrics of malaria in endemic populations is a key component to monitoring and quantifying the impact of current and past control efforts to inform future ones. The International Centers of Excellence for Malaria Research (ICEMR) has the opportunity to evaluate the impact of malaria control interventions across endemic regions that differ in the dominant species, mosquito vector species, resistance to antimalarial drugs and human genetic variants thought to confer protection from infection and clinical manifestations of plasmodia infection. ICEMR programs are conducting field studies at multiple sites with the aim of generating standardized surveillance data to improve the understanding of malaria transmission and to monitor and evaluate the impact of interventions to inform malaria control and elimination programs. In addition, these epidemiological studies provide a vast source of biological samples linked to clinical and environmental “meta-data” to support translational studies of interactions between the parasite, human host, and mosquito vector. Importantly, epidemiological studies at the ICEMR field sites are integrated with entomological studies, including the measurement of the entomological inoculation rate, human biting index, and insecticide resistance, as well as studies of parasite genetic diversity and antimalarial drug resistance.

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  1. Hay SI, Smith DL, Snow RW, , 2008. Measuring malaria endemicity from intense to interrupted transmission. Lancet Infect Dis 8: 369378.[Crossref] [Google Scholar]
  2. Mendis K, Rietveld A, Warsame M, Bosman A, Greenwood B, Wernsdorfer WH, , 2009. From malaria control to eradication: the WHO perspective. Trop Med Int Health 14: 802809.[Crossref] [Google Scholar]
  3. Gillies MI, Wernsdorfer WH, McGregor I, , 1988. Malaria: Principles and Practice of Malariology, vols 1 and 2. , eds. Edinburgh, Scotland: Churchill Livingstone. [Google Scholar]
  4. Tusting LS, Bousema T, Smith DL, Drakeley C, , 2014. Measuring changes in Plasmodium falciparum transmission: precision, accuracy and costs of metrics. Adv Parasitol 84: 151208.[Crossref] [Google Scholar]
  5. Nabarro DN, Tayler EM, , 1998. The “roll back malaria” campaign. Science 280: 20672068.[Crossref] [Google Scholar]
  6. Report WM, , 2012. World Health Organization. Geneva, Switzerland: World Health Organization. [Google Scholar]
  7. Noor AM, Kinyoki DK, Mundia CW, Kabaria CW, Mutua JW, Alegana VA, Fall IS, Snow RW, , 2014. The changing risk of Plasmodium falciparum malaria infection in Africa: 2000–10: a spatial and temporal analysis of transmission intensity. Lancet 383: 17391747.[Crossref] [Google Scholar]
  8. Alonso PL, Tanner M, , 2013. Public health challenges and prospects for malaria control and elimination. Nat Med 19: 150155.[Crossref] [Google Scholar]
  9. Bousema T, Okell L, Felger I, Drakeley C, , 2014. Asymptomatic malaria infections: detectability, transmissibility and public health relevance. Nat Rev Microbiol 12: 833840.[Crossref] [Google Scholar]
  10. Kelly GC, Hale E, Donald W, Batarii W, Bugoro H, Nausien J, Smale J, Palmer K, Bobogare A, Taleo G, Vallely A, Tanner M, Vestergaard LS, Clements AC, , 2013. A high-resolution geospatial surveillance-response system for malaria elimination in Solomon Islands and Vanuatu. Malar J 12: 108.[Crossref] [Google Scholar]
  11. Mueller I, Schoepflin S, Smith TA, Benton KL, Bretscher MT, Lin E, Kiniboro B, Zimmerman PA, Speed TP, Siba P, Felger I, , 2012. Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. Proc Natl Acad Sci USA 109: 1003010035.[Crossref] [Google Scholar]
  12. Report WM, , 2013. World Health Organization. Geneva, Switzerland: World Health Organization. [Google Scholar]
  13. Molineaux L, Gramiccia G, , 1980. The Garki Project: Research on the Epidemiology and Control of Malaria in the Sudan Savanna of West Africa. Geneva, Switzerland: World Health Organization. [Google Scholar]
  14. Hay SI, Snow RW, , 2006. The malaria Atlas Project: developing global maps of malaria risk. PLoS Med 3: e473.[Crossref] [Google Scholar]
  15. Greenwood BM, , 1989. The microepidemiology of malaria and its importance to malaria control. Trans R Soc Trop Med Hyg 83 (Suppl): 2529.[Crossref] [Google Scholar]

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  • Received : 02 Jan 2015
  • Accepted : 29 May 2015
  • Published online : 02 Sep 2015

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