1921
Volume 93, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Phagocytosis of malaria pigment (hemozoin) induces increased activity of matrix metalloproteinase (MMP)-9, an endopeptidase involved in cytokine regulation. In this study, we examined whether a common functional promoter polymorphism (rs3918242) affects infection in pregnancy. Eighteen percent of Ghanaian primiparae carried the minor allele. It was associated with reduced odds of placental hemozoin and of placental as well as peripheral blood parasitemia. The results indicate that a common polymorphism protects against placental malaria indicating that this endopeptidase is involved in susceptibility to .

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2015-07-08
2017-09-23
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  • Received : 18 Dec 2014
  • Accepted : 25 Mar 2015

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