1921
Volume 92, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Malaria was considered as the main cause of fever in Africa. However, with the roll back malaria initiative, the causes of fever in Africa may change. This study aimed to evaluate the prevalence of bacteria and spp. in febrile and afebrile (controls) children from Franceville, Gabon. About 793 blood samples from febrile children and 100 from controls were analyzed using polymerase chain reaction (PCR) coupled with sequencing. spp. was the microorganism most detected in febrile (74.5%, 591/793) and controls (13%, 13/100), < 0.0001. Its coinfection with bacteria was found only in febrile children ( = 0.0001). was the most prevalent bacterium in febrile children (2.8%, 22/793) and controls (3%, 3/100). Eight cases of spp. (including two serovar Paratyphi) and two of were found only among febrile children. spp. was found in 2 controls while was detected in 10 children (in 8 febriles and 2 afebriles). No DNA of other targeted microorganisms was detected. spp. remains prevalent while spp., , and were common bacteria in Gabon. Two fastidious bacteria, and spp., were found. Inclusion of controls should improve the understanding of the causes of fever in sub-Saharan Africa.

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Supplementary PDF

  • Received : 04 Nov 2014
  • Accepted : 07 Feb 2015

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