1921
Volume 92, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Studies on serotype-specific features of dengue and disease severity on adults are limited. We prospectively recruited adult febrile patients without alternate diagnosis to dengue from April 2005 to December 2011. Outcomes were defined using both the World Health Organization (WHO) 1997 and 2009 criteria; Dengue hemorrhagic fever (DHF) and severe dengue (SD). Infecting serotype was identified in 469 dengue-confirmed patients comprising 22.0% dengue virus serotype 1 (DENV-1), 57.1% DENV-2, 17.1% DENV-3, and 3.8% DENV-4. Cases infected with DENV-1 were more likely to present with red eyes whereas presence of joint pain and lower platelet count was associated with DENV-2 cases. After adjusting for potential confounders, DENV-1 was associated with both DHF (adjusted Relative Risk [aRR] = 1.74) and SD (aRR = 2.1) whereas DENV-2 had a lower risk of DHF (aRR = 0.5). DENV-1 genotype 1 and DENV-2 cosmopolitan were the predominant genotypes identified. Infecting dengue serotype and possibly genotype may play an important role in disease severity among adult dengue patients in Singapore.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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2015-05-06
2017-09-22
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References

  1. World Health Organization, 2011. Dengue: Call for Urgent Interventions for a Rapidly Expanding Emerging Disease. Available at: http://applications.emro.who.int/docs/RC_technical_papers_2011_3_14217.pdf. Accessed March 22, 2015.
  2. Chen R, Vasilakis N, , 2011. Dengue—quo tu et quo vadis? Viruses 3: 15621608.[Crossref]
  3. Lee KS, Lai YL, Lo S, Barkham T, Aw P, Ooi PL, Tai JC, Hibberd M, Johansson P, Khoo SP, Ng LC, , 2010. Dengue virus surveillance for early warning, Singapore. Emerg Infect Dis 16: 847849.[Crossref]
  4. Ler TS, Ang LW, Yap GSL, Ng LC, Tai JC, James L, Goh KT, , 2011. Epidemiological characteristics of the 2005 and 2007 dengue epidemics in Singapore—similarities and distinctions. Western Pacific Surveill Response J 2: 2429.
  5. Ministry of Health, 2012. Communicable Disease Surveillance in Singapore 2011. Singapore: Ministry of Health.
  6. Halstead SB, , 2008. Dengue virus-mosquito interactions. Annu Rev Entomol 53: 273291.[Crossref]
  7. Chan KS, Chang JS, Chang K, Lin CC, Huang JH, Lin WR, Chen TC, Hsieh HC, Lin SH, Lin JC, Lu PL, Chen YH, Lin CY, Tsai JJ, , 2009. Effect of serotypes on clinical manifestations of dengue fever in adults. J Microbiol Immunol Infect 42: 471478.
  8. Kumaria R, , 2009. Correlation of disease spectrum among four dengue serotypes: a five years hospital based study from India. Braz J Infect Dis 14: 141146.[Crossref]
  9. Halsey ES, Marks MA, Gotuzzo E, Fiestas V, Suarez L, Vargas J, Aguayo N, Madrid C, Vimos C, Kochel TJ, Laguna-Torres VA, , 2012. Correlation of serotype-specific dengue virus infection with clinical manifestations. PLoS Negl Trop Dis 6: e1638.[Crossref]
  10. Burke DS, Nisalak A, Johnson DE, Scott RM, , 1988. A prospective study of dengue infections in Bangkok. Am J Trop Med Hyg 38: 172180.
  11. Guzman MG, Kouri G, , 2003. Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges. J Clin Virol 27: 113.[Crossref]
  12. Rico-Hesse R, Harrison LM, Salas RA, Tovar D, Nisalak A, Ramos C, Boshell J, de Mesa MT, Nogueira RM, da Rosa AT, , 1997. Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. Virology 230: 244251.[Crossref]
  13. Sangkawibha N, Rojanasuphot S, Ahandrik S, Viriyapongse S, Jatanasen S, Salitul V, Phanthumachinda B, Halstead SB, , 1984. Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak. Am J Epidemiol 120: 653669.[Crossref]
  14. Balmaseda A, Hammond SN, Perez L, Tellez Y, Saborio SI, Mercado JC, Cuadra R, Rocha J, Perez MA, Silva S, Rocha C, Harris E, , 2006. Serotype-specific differences in clinical manifestations of dengue. Am J Trop Med Hyg 74: 449456.
  15. Fried JR, Gibbons RV, Kalayanarooj S, Thomas SJ, Srikiatkhachorn A, Yoon IK, Jarman RG, Green S, Rothman AL, Cummings DA, , 2010. Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006. PLoS Negl Trop Dis 4: e617.[Crossref]
  16. Nisalak A, Endy TP, Nimmannitya S, Kalayanarooj S, Thisayakorn U, Scott RM, Burke DS, Hoke CH, Innis BL, Vaughn DW, , 2003. Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999. Am J Trop Med Hyg 68: 191202.
  17. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, Endy TP, Raengsakulrach B, Rothman AL, Ennis FA, Nisalak A, , 2000. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis 181: 29.[Crossref]
  18. Guzman MG, Alvarez A, Vazquez S, Alvarez M, Rosario D, Pelaez O, Cruz G, Rodriguez R, Pavon A, Gonzalez A, Morier L, Ruiz D, Kouri G, Halstead SB, , 2012. Epidemiological studies on dengue virus type 3 in Playa municipality, Havana, Cuba, 2001–2002. Int J Infect Dis 16: e198e203.[Crossref]
  19. Guzman MG, Kouri G, Valdes L, Bravo J, Alvarez M, Vazques S, Delgado I, Halstead SB, , 2000. Epidemiologic studies on dengue in Santiago de Cuba, 1997. Am J Epidemiol 152: 793799, discussion 804.[Crossref]
  20. Rabaa MA, Ty Hang VT, Wills B, Farrar J, Simmons CP, Holmes EC, , 2010. Phylogeography of recently emerged DENV-2 in southern Viet Nam. PLoS Negl Trop Dis 4: e766.[Crossref]
  21. Zhang C, Mammen MP, Jr Chinnawirotpisan P, Klungthong C, Rodpradit P, Nisalak A, Vaughn DW, Nimmannitya S, Kalayanarooj S, Holmes EC, , 2006. Structure and age of genetic diversity of dengue virus type 2 in Thailand. J Gen Virol 87: 873883.[Crossref]
  22. Rico-Hesse R, , 2003. Microevolution and virulence of dengue viruses. Adv Virus Res 59: 315341.[Crossref]
  23. Gan V, Chua RC, Pok KY, Mok SQ, Yung CF, Lye DC, Ng LC, Leo YS, , 2012. Can commercially available dengue NS1 antigen kits be used for point-of-care testing (POCT) for dengue diagnosis? Int J Infect Dis 16 (Suppl 1): e393.[Crossref]
  24. Low JG, Ong A, Tan LK, Chaterji S, Chow A, Lim WY, Lee KW, Chua R, Chua CR, Tan SWS, Cheung YB, Hibberd ML, Vasudevan SG, Ng L-C, Leo YS, Ooi EE, , 2011. The early clinical features of dengue in adults: challenges for early clinical diagnosis. PLoS Negl Trop Dis 5: e1191.[Crossref]
  25. Lai YL, Chung YK, Tan HC, Yap HF, Yap G, Ooi EE, Ng LC, , 2007. Cost-effective real-time reverse transcriptase PCR (RT-PCR) to screen for dengue virus followed by rapid single-tube multiplex RT-PCR for serotyping of the virus. J Clin Microbiol 45: 935941.[Crossref]
  26. Pok KY, Lai YL, Ang J, Ng LC, , 2010. Evaluation of nonstructural 1 antigen assays for the diagnosis and surveillance of dengue in Singapore. Vector Borne Zoonotic Dis 10: 10091016.[Crossref]
  27. Schreiber MJ, Holmes EC, Ong SH, Soh HS, Liu W, Tanner L, Aw PP, Tan HC, Ng LC, Leo YS, Low JG, Ong A, Ooi EE, Vasudevan SG, Hibberd ML, , 2009. Genomic epidemiology of a dengue virus epidemic in urban Singapore. J Virol 83: 41634173.[Crossref]
  28. World Health Organization, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control, 2nd ed. Geneva, Switzerland: World Health Organization.
  29. World Health Organization, 2009. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control, New edition. Geneva, Switzerland: World Health Organization.
  30. Zou G, , 2004. A modified poisson regression approach to prospective studies with binary data. Am J Epidemiol 159: 702706.[Crossref]
  31. Yew YW, Ye T, Ang LW, Ng LC, Yap G, James L, Chew SK, Goh KT, , 2009. Seroepidemiology of dengue virus infection among adults in Singapore. Ann Acad Med Singapore 38: 667675.
  32. Chuang VW, Wong TY, Leung YH, Ma ES, Law YL, Tsang OT, Chan KM, Tsang IH, Que TL, Yung RW, Liu SH, , 2008. Review of dengue fever cases in Hong Kong during 1998 to 2005. Hong Kong Med J 14: 170177.
  33. Sumarmo Wulur H, Jahja E, Gubler DJ, Suharyono W, Sorensen K, , 1983. Clinical observations on virologically confirmed fatal dengue infections in Jakarta, Indonesia. Bull World Health Organ 61: 693701.
  34. Thai KT, Phuong HL, Thanh Nga TT, Giao PT, Hung le Q, Van Nam N, Binh TQ, Simmons C, Farrar J, Hien TT, van Doorn HR, de Jong MD, de Vries PJ, , 2010. Clinical, epidemiological and virological features of dengue virus infections in Vietnamese patients presenting to primary care facilities with acute undifferentiated fever. J Infect 60: 229237.[Crossref]
  35. Simmons CP, Chau TN, Thuy TT, Tuan NM, Hoang DM, Thien NT, Lien le B, Quy NT, Hieu NT, Hien TT, McElnea C, Young P, Whitehead S, Hung NT, Farrar J, , 2007. Maternal antibody and viral factors in the pathogenesis of dengue virus in infants. J Infect Dis 196: 416424.[Crossref]
  36. Diaz FJ, Black WC, 4th Farfan-Ale JA, Lorono-Pino MA, Olson KE, Beaty BJ, , 2006. Dengue virus circulation and evolution in Mexico: a phylogenetic perspective. Arch Med Res 37: 760773.[Crossref]
  37. Gubler DJ, , 1998. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 11: 480496.
  38. Leitmeyer KC, Vaughn DW, Watts DM, Salas R, Villalobos I, de Chacon IV, Ramos C, Rico-Hesse R, , 1999. Dengue virus structural differences that correlate with pathogenesis. J Virol 73: 47384747.
  39. Chee HY, AbuBakar S, , 2003. Phylogenetic investigation of dengue virus type 2 isolated in Malaysia. Dengue Bull 27: 100107.
  40. Holmes EC, Tio PH, Perera D, Muhi J, Cardosa J, , 2009. Importation and co-circulation of multiple serotypes of dengue virus in Sarawak, Malaysia. Virus Res 143: 15.[Crossref]
  41. Lee KS, Lo S, Tan SS, Chua R, Tan LK, Xu H, Ng LC, , 2011. Dengue virus surveillance in Singapore reveals high viral diversity through multiple introductions and in situ evolution. Infect Genet Evol 12: 7785.[Crossref]
  42. Cologna R, Rico-Hesse R, , 2003. American genotype structures decrease dengue virus output from human monocytes and dendritic cells. J Virol 77: 39293938.[Crossref]
  43. Pryor MJ, Carr JM, Hocking H, Davidson AD, Li P, Wright PJ, , 2001. Replication of dengue virus type 2 in human monocyte-derived macrophages: comparisons of isolates and recombinant viruses with substitutions at amino acid 390 in the envelope glycoprotein. Am J Trop Med Hyg 65: 427434.
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  • Received : 09 Oct 2014
  • Accepted : 24 Feb 2015

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