Volume 92, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The Le Dantec serogroup of rhabdoviruses comprises Le Dantec virus from a human with encephalitis and Keuriliba virus from rodents, each isolated in Senegal. The Kern Canyon serogroup comprises a loosely connected set of rhabdoviruses many of which have been isolated from bats, including Kern Canyon virus from California, Nkolbisson virus from Cameroon, Central African Republic, and Cote d'Ivoire, Kolente virus from Guinea, Mount Elgon bat and Fikirini viruses from Kenya, and Oita virus from Japan. Fukuoka virus isolated from mosquitoes, midges, and cattle in Japan, Barur virus from a rodent in India and Nishimuro virus from pigs in Japan have also been linked genetically or serologically to this group. Here, we analyze the genome sequences and phylogenetic relationships of this set of viruses. We show that they form three subgroups within a monophyletic group, which we propose should constitute the new genus .


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  1. Karabatsos N, , ed., 1985. International Catalogue of Arboviruses Including Certain Other Viruses of Vertebrates. Third edition. San Antonio, TX: American Society for Tropical Medicine and Hygiene. [Google Scholar]
  2. Cropp CB, Prange WC, Monath TP, , 1985. Le Dantec virus: identification as a rhabdovirus associated with human infection and formation of a new serogroup. J Gen Virol 66: 27492754.[Crossref] [Google Scholar]
  3. Calisher CH, Karabatsos N, Zeller H, Digoutte J-P, Tesh RB, Shope RE, Travassos da Rosa AP, St. George TD, , 1989. Antigenic relationships among rhabdoviruses from vertebrates and hematophagous arthropods. Intervirology 30: 241257. [Google Scholar]
  4. Woodruff AW, Ansdell VE, Bowen ET, , 1977. Le Dantec virus infection in a patient who had not been to West Africa. BMJ 2: 16321633.[Crossref] [Google Scholar]
  5. Tesh RB, Travassos da Rosa AP, Travassos da Rosa JS, , 1983. Antigenic relationship among rhabdoviruses infecting terrestrial vertebrates. J Gen Virol 64: 169176.[Crossref] [Google Scholar]
  6. Bourhy H, Cowley JA, Larrous F, Holmes EC, Walker PJ, , 2005. Phylogenetic relationships among rhabdoviruses inferred using the L polymerase gene. J Gen Virol 86: 28492858.[Crossref] [Google Scholar]
  7. Kaneko N, Inaba Y, Akashi H, Miura Y, Shorthose J, Kurashige K, , 1986. Isolation of a new bovine ephemeral fever group virus. Aust Vet J 63: 29.[Crossref] [Google Scholar]
  8. Noda M, Inaba Y, Banjo M, Kubo M, , 1992. Isolation of Fukuoka virus, a member of the Kern Canyon serogroup viruses of the family Rhabdoviridae, from cattle. Vet Microbiol 32: 267271.[Crossref] [Google Scholar]
  9. Johnson HN, , 1965. Disease derived from wildlife. Calif Health 23: 3539. [Google Scholar]
  10. Ndiaye M, Saluzzo JF, Digoutte JP, Mattei X, , 1987. Identification du virus Nkolbisson par microscopie electronique. Ann Inst Pasteur Virol 138: 517521.[Crossref] [Google Scholar]
  11. Salaun JJ, Rickenbach A, Bres P, Brottes H, Germain M, Eouzan JP, Ferrara L, , 1969. The Nkolbisson virus (YM 31-65), a new prototype of arbovirus isolated in Cameroun. Ann Inst Pasteur (Paris) 116: 254260. [Google Scholar]
  12. Berge TO, , 1975. International Catalogue of Arbovirus Including Certain Other Viruses of Vertebrates. Atlanta, GA: Public Health Service (CDC). Volume 75, Issue 8301 of DHEW publication, edition 2. [Google Scholar]
  13. Johnson BK, Shockley P, Chanas AC, Squires EJ, Gardner P, Wallace C, Simpson DI, Bowen ET, Platt GS, Way H, Chandler JA, Highton RB, Hill MN, , 1977. Arbovirus isolations from mosquitoes: Kano Plain, Kenya. Trans R Soc Trop Med Hyg 71: 518521.[Crossref] [Google Scholar]
  14. Sang R, Onyango C, Gachoya J, Mabinda E, Konongoi S, Ofula V, Dunster L, Okoth F, Coldren R, Tesh R, da Rossa AT, Finkbeiner S, Wang D, Crabtree M, Miller B, , 2006. Tick-borne arbovirus surveillance in market livestock, Nairobi, Kenya. Emerg Infect Dis 12: 10741080.[Crossref] [Google Scholar]
  15. Butenko AM, Gromashevsky VL, L'Vov DK, Popov VF, , 1981. First isolations of Barur virus (Rhabdoviridae) from ticks (Acari: Ixodidae) in Africa. J Med Entomol 18: 232234.[Crossref] [Google Scholar]
  16. Kuzmin IV, Hughes GJ, Rupprecht CE, , 2006. Phylogenetic relationships of seven previously unclassified viruses within the family Rhabdoviridae using partial nucleoprotein gene sequences. J Gen Virol 87: 23232331.[Crossref] [Google Scholar]
  17. Kading RC, Gilbert AT, Mossel EC, Crabtree MB, Kuzmin IV, Niezgoda M, Agwanda B, Markotter W, Weil MR, Montgomery JM, Rupprecht CE, Miller BR, , 2013. Isolation and molecular characterization of Fikirini rhabdovirus, a novel virus from a Kenyan bat. J Gen Virol 94: 23932398.[Crossref] [Google Scholar]
  18. Metselaar D, Williams MC, Simpson DI, West R, Mutere FA, , 1969. Mount Elgon bat virus: a hitherto undescribed virus from Rhinolophus hildebrandtii eloquens K. Anderson. Arch Gesamte Virusforsch 26: 183193.[Crossref] [Google Scholar]
  19. Iwasaki T, Inoue S, Tanaka K, Sato Y, Morikawa S, Hayasaka D, Moriyama M, Ono T, Kanai S, Yamada A, Kurata T, , 2004. Characterization of Oita virus 296/1972 of Rhabdoviridae isolated from a horseshoe bat bearing characteristics of both lyssavirus and vesiculovirus. Arch Virol 149: 11391154.[Crossref] [Google Scholar]
  20. Ghedin E, Rogers MB, Widen SG, Guzman H, Travassos da Rosa AP, Wood TG, Fitch A, Popov V, Holmes EC, Walker PJ, Vasilakis N, Tesh RB, , 2013. Kolente virus, a rhabdovirus species isolated from ticks and bats in the Republic of Guinea. J Gen Virol 94: 26092615.[Crossref] [Google Scholar]
  21. Vasilakis N, Forrester NL, Palacios G, Nasar F, Savji N, Rossi SL, Guzman H, Wood TG, Popov V, Gorchakov R, Gonzalez AV, Haddow AD, Watts DM, da Rosa AP, Weaver SC, Lipkin WI, Tesh RB, , 2013. Negevirus: a proposed new taxon of insect-specific viruses with wide geographic distribution. J Virol 87: 24752488.[Crossref] [Google Scholar]
  22. Blasdell KR, Voysey R, Bulach D, Joubert DA, Tesh RB, Boyle DB, Walker PJ, , 2012. Kotonkan and Obodhiang viruses: African ephemeroviruses with large and complex genomes. Virology 425: 143153.[Crossref] [Google Scholar]
  23. Edgar RC, , 2004. MUSCLE: a multiple sequence alignment method with reduced time and space complexity. BMC Bioinformatics 5: 113.[Crossref] [Google Scholar]
  24. Talavera G, Castresana J, , 2007. Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Syst Biol 56: 564577.[Crossref] [Google Scholar]
  25. Guindon S, Dufayard JF, Lefort V, Anisimova M, Hordijk W, Gascuel O, , 2010. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol 59: 307321.[Crossref] [Google Scholar]
  26. Dietzgen RG, Calisher CH, Kurath G, Kuzmin IV, Rodriguez LL, Stone DM, Tesh RB, Tordo N, Walker PJ, Wetzel T, Whitfield AE, King AM, Adams MJ, Carstens EB, Lefkowitz EJ, , 2012. Rhabdoviridae. , eds. Virus Taxonomy, Ninth Report of the International Committee on Taxonomy of Viruses. San Diego, CA: Elsevier, 654681. [Google Scholar]
  27. Adams MJ, Carstens EB, , 2012. Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses, 2012. Arch Virol 157: 14111422.[Crossref] [Google Scholar]
  28. Adams MJ, King AM, Carstens EB, , 2013. Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses, 2013. Arch Virol 158: 20232030.[Crossref] [Google Scholar]
  29. Longdon B, Obbard DJ, Jiggins FM, , 2010. Sigma viruses from three species of Drosophila form a major new clade in the rhabdovirus phylogeny. Proc Biol Sci 277: 3544.[Crossref] [Google Scholar]
  30. Pauszek SJ, Allende R, Rodriguez LL, , 2008. Characterization of the full-length genomic sequences of vesicular stomatitis Cocal and Alagoas viruses. Arch Virol 153: 13531357.[Crossref] [Google Scholar]
  31. Wang L, Wu H, Tao X, Li H, Rayner S, Liang G, Tang Q, , 2013. Genetic and evolutionary characterization of RABVs from China using the phosphoprotein gene. Virol J 10: 14.[Crossref] [Google Scholar]
  32. Nadin-Davis SA, Abdel-Malik M, Armstrong J, Wandeler AI, , 2002. Lyssavirus P gene characterization provides insights into the phylogeny of the genus and identifies structural similarities and diversity within the encoded phosphoprotein. Virology 298: 286305.[Crossref] [Google Scholar]
  33. Pauszek SJ, Rodriguez LL, , 2012. Full-length genome analysis of vesicular stomatitis New Jersey virus strains representing the phylogenetic and geographic diversity of the virus. Arch Virol 157: 22472251.[Crossref] [Google Scholar]
  34. Blasdell KR, Voysey R, Bulach DM, Trinidad L, Tesh RB, Boyle DB, Walker PJ, , 2012. Malakal virus from Africa and Kimberley virus from Australia are geographic variants of a widely distributed ephemerovirus. Virology 433: 236244.[Crossref] [Google Scholar]
  35. Walker PJ, , 2005. Bovine ephemeral fever in Australia and the world. Curr Top Microbiol Immunol 292: 5780. [Google Scholar]
  36. Gubala A, Davis S, Weir R, Melville L, Cowled C, Boyle D, , 2011. Tibrogargan and Coastal Plains rhabdoviruses: genomic characterization, evolution of novel genes and seroprevalence in Australian livestock. J Gen Virol 92: 21602170.[Crossref] [Google Scholar]
  37. Rupprecht CE, Turmelle A, Kuzmin IV, , 2011. A perspective on lyssavirus emergence and perpetuation. Curr Opin Virol 1: 662670.[Crossref] [Google Scholar]
  38. Stone DM, Kerr RC, Hughes M, Radford AD, Darby AC, , 2013. Characterization of the genomes of four putative vesiculoviruses: tench rhabdovirus, grass carp rhabdovirus, perch rhabdovirus and eel rhabdovirus European X. Arch Virol 158: 23712377.[Crossref] [Google Scholar]
  39. Hoffmann B, Beer M, Schutze H, Mettenleiter TC, , 2005. Fish rhabdoviruses: Molecular epidemiology and evolution. Curr Top Microbiol 292: 81117. [Google Scholar]
  40. Agnarsson I, Zambrana-Torrelio CM, Flores-Saldana NP, May-Collado LJ, , 2011. A time-calibrated species-level phylogeny of bats (Chiroptera, Mammalia). PLoS Curr 3: RRN1212.[Crossref] [Google Scholar]
  41. Badrane H, Tordo N, , 2001. Host switching in Lyssavirus history from the Chiroptera to the Carnivora orders. J Virol 75: 80968104.[Crossref] [Google Scholar]
  42. Longdon B, Wilfert L, Osei-Poku J, Cagney H, Obbard DJ, Jiggins FM, , 2011. Host-switching by a vertically transmitted rhabdovirus in Drosophila . Biol Lett 7: 747750.[Crossref] [Google Scholar]

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Supplementary PDF

  • Received : 25 Sep 2014
  • Accepted : 30 Oct 2014
  • Published online : 04 Feb 2015

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