Volume 92, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



A nationwide survey was conducted to obtain an estimate of Chagas disease prevalence among pregnant women in Ecuador. As part of a national probability sample, 5,420 women seeking care for delivery or miscarriage at 15 healthcare facilities were recruited into the study. A small minority of participants reported knowing about Chagas disease or recognized the vector. A national seroprevalence of 0.1% (95% confidence interval [95% CI] = 0.0–0.2%) was found; cases were concentrated in the coastal region (seroprevalence = 0.2%; 95% CI = 0.0–0.4%). No cases of transmission to neonates were identified in the sample. Seropositive participants were referred to the National Chagas Program for evaluation and treatment. Additional studies are necessary to determine if areas of higher prevalence exist in well-known endemic provinces and guide the development of a national strategy for elimination of mother-to-child transmission of Chagas disease in Ecuador.


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  1. Rassi A, Jr Rassi A, Marin-Neto JA, , 2010. Chagas disease. Lancet 375: 13881402.[Crossref] [Google Scholar]
  2. Aguilar VH, Abad-Franch F, Racines VJ, Paucar CA, , 1999. Epidemiology of Chagas disease in Ecuador. A brief review. Mem Inst Oswaldo Cruz 94 (Suppl 1): 387393.[Crossref] [Google Scholar]
  3. Black CL, Ocana S, Riner D, Costales JA, Lascano MS, Davila S, Arcos-Teran L, Seed JR, Grijalva MJ, , 2007. Household risk factors for Trypanosoma cruzi seropositivity in two geographic regions of Ecuador. J Parasitol 93: 1216.[Crossref] [Google Scholar]
  4. Black CL, Ocana-Mayorga S, Riner DK, Costales JA, Lascano MS, Arcos-Teran L, Preisser JS, Seed JR, Grijalva MJ, , 2009. Seroprevalence of Trypanosoma cruzi in rural Ecuador and clustering of seropositivity within households. Am J Trop Med Hyg 81: 10351040.[Crossref] [Google Scholar]
  5. Amunarriz M, Chico ME, Guderian RH, , 1991. Chagas disease in Ecuador: a sylvatic focus in the Amazon region. J Trop Med Hyg 94: 145149. [Google Scholar]
  6. Grijalva MJ, Escalante L, Paredes RA, Costales JA, Padilla A, Rowland EC, Aguilar HM, Racines J, , 2003. Seroprevalence and risk factors for Trypanosoma cruzi infection in the Amazon region of Ecuador. Am J Trop Med Hyg 69: 380385. [Google Scholar]
  7. Chico M, Sandoval C, Guevara A, Calvopina M, Cooper PJ, Reed SG, Guderian RH, , 1997. Chagas disease in Ecuador: evidence for disease transmission in an indigenous population in the Amazon region. Mem Inst Oswaldo Cruz 92: 317320.[Crossref] [Google Scholar]
  8. Guevara AG, Atherton RD, Wauters MA, Vicuna Y, Nelson M, Prado J, Kato H, Calvopina MH, Hashiguchi Y, , 2013. Seroepidemiological study of chagas disease in the southern Amazon region of Ecuador. Trop Med Health 41: 2125.[Crossref] [Google Scholar]
  9. Howard EJ, Xiong X, Carlier Y, Sosa-Estani S, Buekens P, , 2014. Frequency of the congenital transmission of Trypanosoma cruzi: a systematic review and meta-analysis. BJOG 121: 2233.[Crossref] [Google Scholar]
  10. PAHO, 2006. Quantitative Estimation of Chagas Disease in the Americas. Washington, DC: Pan American Health Organization. [Google Scholar]
  11. Carlier Y, Torrico F, Sosa-Estani S, Russomando G, Luquetti A, Freilij H, Albajar Vinas P, , 2011. Congenital Chagas disease: recommendations for diagnosis, treatment and control of newborns, siblings and pregnant women. PLoS Negl Trop Dis 5: e1250.[Crossref] [Google Scholar]
  12. Sicuri E, Munoz J, Pinazo MJ, Posada E, Sanchez J, Alonso PL, Gascon J, , 2011. Economic evaluation of Chagas disease screening of pregnant Latin American women and of their infants in a non endemic area. Acta Trop 118: 110117.[Crossref] [Google Scholar]
  13. Altcheh J, Moscatelli G, Moroni S, Garcia-Bournissen F, Freilij H, , 2011. Adverse events after the use of benznidazole in infants and children with Chagas disease. Pediatrics 127: e212e218.[Crossref] [Google Scholar]
  14. Feilij H, Muller L, Gonzalez Cappa SM, , 1983. Direct micromethod for diagnosis of acute and congenital Chagas' disease. J Clin Microbiol 18: 327330. [Google Scholar]
  15. Sosa-Estani S, Cura E, Velazquez E, Yampotis C, Segura EL, , 2009. Etiological treatment of young women infected with Trypanosoma cruzi, and prevention of congenital transmission. Rev Soc Bras Med Trop 42: 484487.[Crossref] [Google Scholar]
  16. Murcia L, Carrilero B, Munoz-Davila MJ, Thomas MC, Lopez MC, Segovia M, , 2013. Risk factors and primary prevention of congenital Chagas disease in a nonendemic country. Clin Infect Dis 56: 496502.[Crossref] [Google Scholar]
  17. Sanchez-Gomez A, Grijalva MJ, Silva-Aycaguer LC, Tamayo S, Yumiseva CA, Costales JA, Jacobson JO, Chiriboga M, Champutiz E, Mosquera C, Larrea M, Cevallos W, , 2014. HIV and syphilis infection in pregnant women in Ecuador: prevalence and characteristics of antenatal care. Sex Transm Infect 90: 7075.[Crossref] [Google Scholar]
  18. Munoz J, Coll O, Juncosa T, Verges M, del Pino M, Fumado V, Bosch J, Posada EJ, Hernandez S, Fisa R, Boguna JM, Gallego M, Sanz S, Portus M, Gascon J, , 2009. Prevalence and vertical transmission of Trypanosoma cruzi infection among pregnant Latin American women attending 2 maternity clinics in Barcelona, Spain. Clin Infect Dis 48: 17361740.[Crossref] [Google Scholar]
  19. Ramos JM, Pinargote H, Andreu M, Sastre J, Torrus D, Martinez-Escoriza JC, Portilla J, , 2014. Prevalence of Trypanosoma cruzi infection in Latin American pregnant women and level of compliance of the Valencian Health Programme in the city of Alicante. Epidemiol Infect 142: 888890.[Crossref] [Google Scholar]
  20. CEPAR Yépez ME, Sotomayor JO, Velasteguí AV, Valdivieso NO, Morán LR, Chicaiza RA, Pérez EA, , 2005. Salud materna y salud del niño-niña. , eds. Informe de Endemain 2004. Quito, Ecudaor: Centro de Estudios de Población y desarrollo Social–CEPAR, 4. [Google Scholar]
  21. CEPAR, 1987. Encuesta Demográfica y de Salud Familiar. Quito, Ecuador: Centro de Estudios de Población y Paternidad Responsable–CEPAR. [Google Scholar]
  22. Romero M, Postigo J, Schneider D, Chippaux JP, Santalla JA, Brutus L, , 2011. Door-to-door screening as a strategy for the detection of congenital Chagas disease in rural Bolivia. Trop Med Int Health 16: 562569.[Crossref] [Google Scholar]
  23. Briceno-Leon R, , 2009. Chagas disease in the Americas: an ecohealth perspective. Cad Saude Publica 25 (Suppl 1): S71S82.[Crossref] [Google Scholar]

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  • Received : 05 Sep 2014
  • Accepted : 05 Dec 2014
  • Published online : 01 Apr 2015

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