1921
Volume 92, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Acute human immunodeficiency virus (HIV) infection (AHI) refers to the period between viral transmission and development of an adaptive immune response to HIV antigens (seroconversion) usually lasting 6–8 weeks. Rare cases have been described in which HIV-infected patients fail to seroconvert and instead, develop rapid HIV-mediated clinical decline. We report the case of a Mozambican woman with AHI and malaria coinfection who showed atypical seroconversion and experienced rapid deterioration and death within 14 weeks of diagnosis with AHI. Atypical seroconversion may be associated with rapid progression. Fourth generation rapid tests could lead to earlier identification and intervention for this vulnerable subgroup.

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References

  1. Cohen M, Gay C, Busch M, Hecht F, , 2012. The detection of acute HIV infection. J Infect Dis 202: 270277.[Crossref] [Google Scholar]
  2. Fiebig EW, Wright DJ, Rawal BD, Garrett PE, Schumacher RT, Peddada L, Heldebrant C, Smith R, Conrad A, Kleinman SH, Busch MP, , 2003. Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS 17: 18711879.[Crossref] [Google Scholar]
  3. McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF, , 2010. The immune response during acute HIV-1 infection: clues for vaccine development. Nat Rev Immunol 10: 1123.[Crossref] [Google Scholar]
  4. Burin des Roziers N, Sotto A, Arnaud A, Saissi G, Nasar O, Jourdan J, , 1995. Kinetics of detection of antibodies to HIV-1 and plasma p24 antigens during a severe primary HIV-1 infection. AIDS 9: 528529.[Crossref] [Google Scholar]
  5. Sullivan PS, Schable C, Koch W, Do AN, Spira T, Lansky A, Ellenberger D, Lal RB, Hyer C, Davis R, Marx M, Paul S, Kent J, Armor R, McFarland J, Lafontaine J, Mottice S, Cassol SA, Michael N, , 1999. Persistently negative HIV-1 antibody enzyme immunoassay screening results for patients with HIV-1 infection and AIDS: serologic, clinical, and virologic results. AIDS 13: 8996.[Crossref] [Google Scholar]
  6. Ellenberger DL, Sullivan PS, Dorn J, Schable C, Spira TJ, Folks TM, Lal RB, , 1999. Viral and immunologic examination of human immunodeficiency virus type 1-infected, persistently seronegative persons. J Infect Dis 180: 10331042.[Crossref] [Google Scholar]
  7. Dalmau J, Puertas MC, Azuara M, Mariño A, Frahm N, Mothe B, Izquierdo-Useros N, Buzón MJ, Paredes R, Matas L, Allen TM, Brander C, Rodrigo C, Clotet B, Martinez-Picado J, , 2009. Contribution of immunological and virological factors to extremely severe primary HIV type 1 infection. Clin Infect Dis 48: 229238.[Crossref] [Google Scholar]
  8. Pantaleo G, Fauci A, , 1996. Immunopathogenesis of HIV infection. Annu Rev Microbiol 50: 825854.[Crossref] [Google Scholar]
  9. Martin MP, Carrington M, , 2013. Immunogenetics of HIV disease. Immunol Rev 254: 245264.[Crossref] [Google Scholar]
  10. Carrington M, Nelson GW, Martin MP, Kissner T, Vlahov D, Goedert JJ, Kaslow R, Buchbinder S, Hoots K, O'Brien SJ, , 1999. HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage. Science 283: 17481752.[Crossref] [Google Scholar]
  11. Tang J, Costello C, Keet IP, Rivers C, Leblanc S, Karita E, Allen S, Kaslow RA, , 1999. HLA class I homozygosity accelerates disease progression in human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses 15: 317324.[Crossref] [Google Scholar]
  12. Spivak AM, Sydnor ER, Blankson JN, Gallant JE, , 2010. Seronegative HIV-1 infection: a review of the literature. AIDS 24: 14071414.[Crossref] [Google Scholar]
  13. Michael NL, Brown AE, Voigt RF, Frankel SS, Mascola JR, Brothers KS, Louder M, Birx DL, Cassol SA, , 1997. Rapid disease progression without seroconversion following primary human immunodeficiency virus type 1 infection–evidence for highly susceptible human hosts. J Infect Dis 175: 13521359.[Crossref] [Google Scholar]
  14. Novitsky V, Gaolathe T, Woldegabriel E, Makhema J, Essex M, , 2007. A seronegative case of HIV-1 subtype C infection in Botswana. Clin Infect Dis 45: e68e71.[Crossref] [Google Scholar]
  15. Corcoran C, Hardie D, , 2008. HIV-1 subtype C seronegative AIDS. Clin Infect Dis 46: 322323.[Crossref] [Google Scholar]
  16. Burke DS, Redfield RR, Putman P, Alexander SS, , 1987. Variations in western blot banding patterns of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus. J Clin Microbiol 25: 8184. [Google Scholar]
  17. Mehta SU, Rupprecht KR, Hunt JC, Kramer DE, McRae BJ, Allen RG, Dawson GJ, Devare SG, , 1990. Prevalence of antibodies to the core protein P17, a serological marker during HIV-1 infection. AIDS Res Hum Retroviruses 6: 443454.[Crossref] [Google Scholar]
  18. Van Geertruyden JP, Mulenga M, Kasongo W, Polman K, Colebunders R, Kestens L, D'Alessandro U, , 2006. CD4 T-cell count and HIV-1 infection in adults with uncomplicated malaria. J Acquir Immune Defic Syndr 43: 363367.[Crossref] [Google Scholar]
  19. Alemu A, Shiferaw Y, Addis Z, Mathewos B, Birhan W, , 2013. Effect of Malaria on HIV/AIDS transmission and progression. Parasit Vectors 6: 18.[Crossref] [Google Scholar]
  20. González R, Ataíde R, Naniche D, Menéndez C, Mayor A, , 2012. HIV and malaria interactions: where do we stand? Expert Rev Anti Infect Ther 10: 153165.[Crossref] [Google Scholar]
  21. Gray JM, Cohn DL, , 2013. Tuberculosis and HIV coinfection. Semin Respir Crit Care Med 34: 3243.[Crossref] [Google Scholar]
  22. Kouassi B, N'Gom A, Horo K, Godé C, Ahui B, Emvoudou NM, Koffi N, Anon JC, Konaté KF, Itchi M, Koffi MO, Ano A, Manewa SF, Gro Bi A, Aka-Danguy E, Gnazé A, Touré K, , 2013. Correlation of the manifestations of tuberculosis and the degree of immunosuppression in patients with HIV. Rev Mal Respir 30: 549554.[Crossref] [Google Scholar]
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  • Received : 02 Sep 2014
  • Accepted : 16 Dec 2014
  • Published online : 01 Apr 2015

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