1921
Volume 92, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Approximately 8% of the population in Papua New Guinea (PNG) has chronic hepatitis B virus (HBV) infection. To decrease the burden of chronic HBV infection, a national 3-dose infant hepatitis B vaccination program was implemented starting in 1989, with a birth dose (BD) added to the schedule in 1992. To assess the impact of the hepatitis B vaccination program, we conducted a serosurvey among children born after vaccine introduction. During 2012–2013, a cross-sectional stratified four-stage cluster survey was conducted to estimate hepatitis B surface antigen (HBsAg) prevalence among children 4–6 years of age. We collected demographic data, vaccination history, and tested children for HBsAg. Of 2,133 participants, 2,130 children had vaccination data by either card or recall: 28% received a BD; 81% received ≥ 3 vaccine doses. Of 2,109 children providing a blood sample, 60 (2.3%) tested positive for HBsAg. This is the largest, most geographically diverse survey of hepatitis B vaccination and HBsAg seroprevalence done in PNG. Progress has been made in PNG toward the Western Pacific Regional goal to reduce the prevalence of chronic HBV infection to < 1% by 2017 among 5-year-old children. Vaccination efforts should be strengthened, including increasing BD coverage and completing the 3-dose series.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.14-0537
2015-03-04
2017-11-20
Loading full text...

Full text loading...

/deliver/fulltext/14761645/92/3/501.html?itemId=/content/journals/10.4269/ajtmh.14-0537&mimeType=html&fmt=ahah

References

  1. Goldstein ST, Zhou F, Hadler SC, Bell BP, Mast EE, Margolis HS, , 2005. A mathematical model to estimate global hepatitis B disease burden and vaccination impact. Int J Epidemiol 34: 13291339.[Crossref]
  2. Ott JJ, Stevens GA, Groeger J, Wiersma ST, , 2012. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 30: 22122219.[Crossref]
  3. Clements CJ, Baoping Y, Crouch A, Hipgrave D, Mansoor O, Nelson CB, Treleaven S, van Konkelenberg R, Wiersma S, , 2006. Progress in the control of hepatitis B infection in the Western Pacific Region. Vaccine 24: 19751982.[Crossref]
  4. Hennessey K, Mendoza-Aldana J, Bayutas B, Lorenzo-Mariano KM, Diorditsa S, , 2013. Hepatitis B control in the World Health Organization's Western Pacific Region: targets, strategies, status. Vaccine 31 (Suppl 9): J85J92.[Crossref]
  5. World Health Organization Regional Office for the Western Pacific, 2007. Western Pacific Regional Plan for Hepatitis B Control Through Immunization. Manila, Philippines.
  6. World Health Organization, 2014. Immunization Profile - Papua New Guinea. Available at: http://apps.who.int/immunization_monitoring/globalsummary/countries?countrycriteria%5Bcountry%5D%5B%5D=PNG. Accessed March 31, 2014.
  7. WHO, 2012. Sample Design and Procedures for Hepatitis B Immunization Surveys: A Companion to the WHO Cluster Survey Reference Manual. Geneva: World Health Organization.
  8. Lien TX, Tien NT, Chanpong GF, Cuc CT, Yen VT, Soderquist R, Laras K, Corwin A, , 2000. Evaluation of rapid diagnostic tests for the detection of human immunodeficiency virus types 1 and 2, hepatitis B surface antigen, and syphilis in Ho Chi Minh City, Vietnam. Am J Trop Med Hyg 62: 301309.
  9. Alere, 2011. Alere Determine HBsAg Package Insert. Chiba, Japan. Available at: http://www.alere.com/EN_ZA/products/alere-determine-hbsag/.
  10. World Health Organization, 2001. Hepatitis B Surface Antigen Assays: Operational Characteristics (Phase 1) Report 1. Geneva: World Health Organization.
  11. Tozer RA, , 1996. Papua New Guinea Red Cross Blood Transfusion Service: present status and future considerations. P N G Med J 39: 3842.
  12. Brabin L, Brabin BJ, Dimitrakakis M, Gust I, , 1989. Factors affecting the prevalence of infection with hepatitis B virus among non-pregnant women in the Alexishafen area of Papua New Guinea. Ann Trop Med Parasitol 83: 365374.[Crossref]
  13. Sapuri M, Babona DM, Klufio CA, Vince JD, , 1991. Hepatitis B surface and e antigen seropositivity in mothers and cord blood at Port Moresby General Hospital: implications for a control program. P N G Med J 34: 234237.
  14. Sanders RC, Lewis D, Dyke T, Alpers MP, , 1992. Markers of hepatitis B infection in Tari District, Southern Highlands Province, Papua New Guinea. P N G Med J 35: 197201.
  15. Spooner V, Richens J, Sanders R, , 1990. Hepatitis B surface antigen, e antigen and HBV DNA in healthy antenatal patients attending Goroka Hospital and their relationship to tattooing practices. P N G Med J 33: 1115.
  16. Hawkes RA, Boughton CR, Ferguson V, Vale TG, , 1981. The seroepidemiology of hepatitis in Papua New Guinea. II. A long-term study of hepatitis B. Am J Epidemiol 114: 563573.[Crossref]
  17. Nemba K, Babona DM, Vince JD, , 1993. Age-specific prevalence of hepatitis B surface antigenemia in hospitalized children at Port Moresby, Papua New Guinea (a cross-sectional study with implications for the Hepatitis B Control Programme). Ann Trop Paediatr 13: 237241.[Crossref]
  18. Yamaguchi K, Inaoka T, Ohtsuka R, Akimichi T, Hongo T, Kawabe T, Nakazawa M, Futatsuka M, Takatsuki K, , 1993. HTLV-I, HIV-I, and hepatitis B and C viruses in Western Province, Papua New Guinea: a serological survey. Jpn J Cancer Res 84: 715719.[Crossref]
  19. Regional Committee of the Western Pacific, 2013. Hepatitis B control through vaccination: setting the target, Manila, Philippines. WPR RC 64: R5.
  20. Mao B, Patel MK, Hennessey K, Duncan RJ, Wannemuehler K, Soeung SC, , 2013. Prevalence of chronic hepatitis B virus infection after implementation of a hepatitis B vaccination program among children in three provinces in Cambodia. Vaccine 31: 44594464.[Crossref]
  21. Downing SG, Lagani W, Guy R, Hellard M, , 2008. Barriers to the delivery of the hepatitis B birth dose: a study of five Papua New Guinean hospitals in 2007. P N G Med J 51: 4755.
  22. Wang L, Li J, Chen H, Li F, Armstrong GL, Nelson C, Ze W, Shapiro CN, , 2007. Hepatitis B vaccination of newborn infants in rural China: evaluation of a village-based, out-of-cold-chain delivery strategy. Bull World Health Organ 85: 688694.[Crossref]
  23. Hipgrave DB, Tran TN, Huong VM, Dat DT, Nga NT, Long HT, Van NT, Maynard JE, Biggs BA, , 2006. Immunogenicity of a locally produced hepatitis B vaccine with the birth dose stored outside the cold chain in rural Vietnam. Am J Trop Med Hyg 74: 255260.
  24. National Statistics Office, 2009. Papua New Guinea Demographic and Health Survey, 2006. Port Moresby, Papua New Guinea.
  25. Morgan C, Rahadi A, , 2011. Costs and outcomes analysis for integration of birth-dose vaccination with community postnatal care in Papua New Guinea. Technical Report for National Department of Health and Country Offices of WHO and UNICEF, Papua New Guinea.
  26. Otto BF, Suarnawa IM, Stewart T, Nelson C, Ruff TA, Widjaya A, Maynard JE, , 1999. At-birth immunization against hepatitis B using a novel pre-filled immunization device stored outside the cold chain. Vaccine 18: 498502.[Crossref]
  27. Sutanto A, Suarnawa IM, Nelson CM, Stewart T, Soewarso TI, , 1999. Home delivery of heat-stable vaccines in Indonesia: outreach immunization with a prefilled, single-use injection device. Bull World Health Organ 77: 119126.
  28. Mast EE, Margolis HS, Fiore AE, Brink EW, Goldstein ST, Wang SA, Moyer LA, Bell BP, Alter MJ, Advisory Committee on Immunization Practices; , 2005. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) part 1: immunization of infants, children, and adolescents. MMWR Recomm Rep 54: 131.
  29. 2009. Hepatitis B vaccines. Wkly Epidemiol Rec 84: 405419.
  30. 2011. Reaching Every Child-Papua New Guinea. Available at: http://aid.dfat.gov.au/countries/pacific/png/Documents/red-strategy-png-report.pdf. Accessed December 21, 2014.
  31. Miles M, Ryman TK, Dietz V, Zell E, Luman ET, , 2013. Validity of vaccination cards and parental recall to estimate vaccination coverage: a systematic review of the literature. Vaccine 31: 15601568.[Crossref]
  32. Nguyen TH, Vu MH, Nguyen VC, Nguyen LH, Toda K, Nguyen TN, Dao S, Wannemuehler KA, Hennessey KA, , 2014. A reduction in chronic hepatitis B virus infection prevalence among children in Vietnam demonstrates the importance of vaccination. Vaccine 32: 217222.[Crossref]
  33. Al Awaidy ST, Bawikar SP, Al Busaidy SS, Al Mahrouqi S, Al Baqlani S, Al Obaidani I, Alexander J, Patel MK, , 2013. Progress toward elimination of hepatitis B virus transmission in Oman: impact of hepatitis B vaccination. Am J Trop Med Hyg 89: 811815.[Crossref]
  34. Liang X, Bi S, Yang W, Wang L, Cui G, Cui F, Zhang Y, Liu J, Gong X, Chen Y, Wang F, Zheng H, Guo J, Jia Z, Ma J, Wang H, Luo H, Li L, Jin S, Hadler SC, Wang Y, , 2009. Epidemiological serosurvey of hepatitis B in China–declining HBV prevalence due to hepatitis B vaccination. Vaccine 27: 65506557.[Crossref]
  35. Szmuness W, , 1975. Recent advances in the study of the epidemiology of hepatitis B. Am J Pathol 81: 629650.
  36. Kruszon-Moran D, McQuillan GM, , 2005. Seroprevalence of six infectious diseases among adults in the United States by race/ethnicity: data from the third national health and nutrition examination survey, 1988–94. Adv Data (352): 19.
  37. Pasquini P, Kahn HA, Pileggi D, Pana A, Terzi J, Guzzanti E, , 1983. Prevalence of hepatitis B markers in Italy. Am J Epidemiol 118: 699709.[Crossref]
  38. Stuver SO, Boschi-Pinto C, Trichopoulos D, , 1997. Infection with hepatitis B and C viruses, social class and cancer. IARC Sci Publ (138): 319324.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.14-0537
Loading
/content/journals/10.4269/ajtmh.14-0537
Loading

Data & Media loading...

  • Received : 26 Aug 2014
  • Accepted : 24 Nov 2014

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error