1921
Volume 92, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Transmission of dengue virus (DENV) from mosquito to human is dependent upon the survival of the mosquito beyond the virus extrinsic incubation period. Previous studies report conflicting results of the effects of DENV on survival. Here, we describe the effect of DENV on the short-term survival (up to 12 d) of 4,321 mosquitoes blood-fed on 150 NS1-positive dengue patients hospitalized in the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. Mosquito survival was not different between cohorts that fed upon blood from which 0% of mosquitoes became DENV infected ( = 88 feeds), or 100% became infected ( = 116 feeds). Subgroup analysis also did not reveal serotype-dependent differences in survival, nor a relationship between survival and human plasma viremia levels. These results suggest that DENV infection adds minimal cost to , an important finding when parameterizing the vector competence of this mosquito.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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2015-03-04
2017-11-20
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References

  1. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GR, Simmons CP, Scott TW, Farrar JJ, Hay SI, , 2013. The global distribution and burden of dengue. Nature 496: 504507.[Crossref]
  2. Dupont-Rouzeyrol M, Caro V, Guillaumot L, Vazeille M, D'Ortenzio E, Thiberge JM, Baroux N, Gourinat AC, Grandadam M, Failloux AB, , 2012. Chikungunya virus and the mosquito vector Aedes aegypti in New Caledonia (South Pacific Region). Vector Borne Zoonotic Dis 12: 10361041.[Crossref]
  3. Dubrulle M, Mousson L, Moutailler S, Vazeille M, Failloux AB, , 2009. Chikungunya virus and Aedes mosquitoes: saliva is infectious as soon as two days after oral infection. PLoS ONE 4: e5895.[Crossref]
  4. Davis NC, , 1932. The effect of various temperatures in modifying the extrinsic incubation period of the yellow fever virus in Aedes aegypti . Am J Epidemiol 16: 163176.[Crossref]
  5. Lambrechts L, Scott TW, , 2009. Mode of transmission and the evolution of arbovirus virulence in mosquito vectors. Proc Biol Sci 276: 13691378.[Crossref]
  6. Maciel-de-Freitas R, Koella JC, Lourenço-de-Oliveira R, , 2011. Lower survival rate, longevity and fecundity of Aedes aegypti (Diptera: Culicidae) females orally challenged with dengue virus serotype 2. Trans R Soc Trop Med Hyg 105: 452458.[Crossref]
  7. Joy TK, Gutierrez EH, Ernst K, Walker KR, Carriere Y, Torabi M, Riehle MA, , 2012. Aging field collected Aedes aegypti to determine their capacity for dengue transmission in the Southwestern United States. PLoS ONE 7: e26026.[Crossref]
  8. Carrington LB, Seifert SN, Armijos MV, Lambrechts L, Scott TW, , 2013. Reduction of Aedes aegypti vector competence for dengue virus under large temperature fluctuations. Am J Trop Med Hyg 88: 689697.[Crossref]
  9. Carrington LB, Armijos MV, Lambrechts L, Scott TW, , 2013. Fluctuations at low mean temperatures accelerate dengue virus transmission by Aedes aegypti . PLoS Negl Trop Dis 7: e2190.[Crossref]
  10. Moutailler S, Guichoux E, Vazeille M, Failloux AB, , 2010. Differential mortalities of dengue-infected Aedes aegypti: preliminary results. Ann Soc Entomol Fr 46: 359366.
  11. Nguyen NM, Kien DT, Trung VT, Quyen NT, Chau TN, Lon VT, Dui LT, Nguyen HL, Farrar J, Holmes EC, Rabaa MA, Bryant JE, Truong NT, Huong NT, Lan NT, Mai PP, Hung NT, Tai LT, Wills B, Chau NV, Wolbers M, Simmons CP, , 2013. Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes. Proc Natl Acad Sci USA 10: 90729077.[Crossref]
  12. Duong TH, Vu TT, Hanh TN, Tran Ngyuen BC, Huynh LA, Wills BA, Simmons CP, , 2011. Validation of an internally controlled one-step real-time multiplex RT-PCR assay for the detection and quantitation of dengue virus RNA in plasma. J Virol Methods 177: 168173.[Crossref]
  13. Schmid-Hempel P, , 2005. Evolutionary ecology of insect immune defenses. Annu Rev Entomol 50: 529551.[Crossref]
  14. Styer LM, Carey JR, Wang J-L, Scott TW, , 2007. Mosquitoes do senesce: departure from the paradigm of constant mortality. Am J Trop Med Hyg 76: 111117.
  15. Harrington LC, Vermeylen F, Jones JJ, Kitthawee S, Sithiprasasna R, Edman JD, Scott TW, , 2008. Age-dependent survival of the dengue vector Aedes aegypti (Diptera: Culicidae) demonstrated by simultaneous release-recapture of different age cohorts. J Med Entomol 45: 307313.[Crossref]
  16. Muir LE, Kay BH, , 1998. Aedes aegypti survival and dispersal estimated by mark-release-recapture in northern Australia. Am J Trop Med Hyg 58: 277282.
  17. Harrington LC, Buonaccorsi JP, Edman JD, Costero A, Kittayapong P, Clark GG, Scott TW, , 2001. Analysis of survival of young and old Aedes aegypti (Diptera: Culicidae) from Puerto Rico and Thailand. J Med Entomol 38: 537547.[Crossref]
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Supplementary Data

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  • Received : 08 Aug 2014
  • Accepted : 27 Oct 2014

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