Volume 93, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Skin ulcer development in cutaneous leishmaniasis due to infection is associated with a mononuclear cell infiltrate and high levels of tumor necrosis factor (TNF). Herein, we show that despite the absence of -driven TNF, a cutaneous leishmaniasis patient with acquired immunodeficiency syndrome developed a skin ulcer. The presence of mononuclear phagocytes and high levels of TNF, chemokine (C-C motif) ligand 2 (CCL2), and metalloproteinase-9 in tissue are identified as potential contributors to immunopathology observed in -infected patients.


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  • Received : 30 Jul 2014
  • Accepted : 22 Sep 2015
  • Published online : 09 Dec 2015

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