1921
Volume 92, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Knowledge of adult dengue virus (DENV) infection from Hanoi, Vietnam, is limited. In 2008, we prospectively studied 143 (77 male) confirmed (nonstructural 1 antigen enzyme-linked immunosorbent assay [ELISA], DENV polymerase chain reaction, paired serology) adult dengue patients of median age 23.5 (range 16–72) years. They were admitted to the National Hospital for Tropical Diseases, Hanoi, on median illness day (D) 5 (range 1–8). By D8, 141 (98.6%) were afebrile. Platelet counts and hematocrit (median, interquartile range [IQR]) nadired and peaked on D5 and D4, respectively: 40,000/μL (10,000–109,000/μL), 43.4% (34.9–49.7%). Four (2.8%) patients had severe dengue: 1) D10 shock ( = 1) and 2) aspartate aminotransferase (AST) ≥ 1,000 IU/L ( = 3, D5 and D7). Of 143 patients, 118 (82.5%) had ≥ 1 warning sign (World Health Organization [WHO] 2009 criteria): mucosal bleeding 66/143 (46.1%), soft tissue edema 54/143 (37.7%), and ultrasound detected plasma leakage (pleural effusions/ascites) 30/129 (23.25%). 138 (96.5%) patients received intravenous (IV) fluids: 3 L (IQR: 0.5–8.5 L). Most patients had non-severe dengue with warning signs. High rates of edema and plasma leakage may be explained partly by liberal use of IV fluids. Studies are needed on optimizing fluid management in non-severe adult dengue.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.14-0472
2015-06-03
2017-11-19
Loading full text...

Full text loading...

/deliver/fulltext/14761645/92/6/1141.html?itemId=/content/journals/10.4269/ajtmh.14-0472&mimeType=html&fmt=ahah

References

  1. Thai KT, Nishiura H, Hoang PL, Tran NT, Phan GT, Le HQ, Tran BQ, Nguyen NV, de Vries PJ, , 2011. Age-specificity of clinical dengue during primary and secondary infections. PLoS Negl Trop Dis 5: e1180.[Crossref]
  2. Yew YW, Ye T, Ang LW, Ng LC, Yap G, James L, Chew SK, Goh KT, , 2009. Seroepidemiology of dengue virus infection among adults in Singapore. Ann Acad Med Singapore 38: 667675.
  3. Wills BA, Oragui EE, Stephens AC, Daramola OA, Dung NM, Loan HT, Chau NV, Chambers M, Stepniewska K, Farrar JJ, Levin M, , 2002. Coagulation abnormalities in dengue hemorrhagic fever: serial investigations in 167 Vietnamese children with dengue shock syndrome. Clin Infect Dis 35: 277285.[Crossref]
  4. Burke DS, Nisalak A, Johnson DE, Scott RM, , 1988. A prospective study of dengue infections in Bangkok. Am J Trop Med Hyg 38: 172180.
  5. Leo YS, Thein TL, Fisher DA, Low JG, Oh HM, Narayanan RL, Gan VC, Lee VJ, Lye DC, , 2011. Confirmed adult dengue deaths in Singapore: 5-year multi-center retrospective study. BMC Infect Dis 11: 123.[Crossref]
  6. Yacoub S, Griffiths A, Chau TT, Simmons CP, Wills B, Hien TT, Henein M, Farrar J, , 2012. Cardiac function in Vietnamese patients with different dengue severity grades. Crit Care Med 40: 477483.[Crossref]
  7. Simmons CP, Farrar JJ, Nguyen vV, Wills B, , 2012. Dengue. N Engl J Med 366: 14231432.[Crossref]
  8. World Health Organization, 2009. Dengue Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition. Geneva, Switzerland: World Health Organization.
  9. Bandyopadhyay S, Lum LC, Kroeger A, , 2006. Classifying dengue: a review of the difficulties in using the WHO case classification for dengue haemorrhagic fever. Trop Med Int Health 11: 12381255.[Crossref]
  10. Balmaseda A, Hammond SN, Perez MA, Cuadra R, Solano S, Rocha J, Idiaquez W, Harris E, , 2005. Short report: assessment of the World Health Organization scheme for classification of dengue severity in Nicaragua. Am J Trop Med Hyg 73: 10591062.
  11. Phuong CX, Nhan NT, Kneen R, Thuy PT, van Thien C, Nga NT, Thuy TT, Solomon T, Stepniewska K, Wills B, Dong Nai Study Group, , 2004. Clinical diagnosis and assessment of severity of confirmed dengue infections in Vietnamese children: is the world health organization classification system helpful? Am J Trop Med Hyg 70: 172179.
  12. Alexander N, Balmaseda A, Coelho IC, Dimaano E, Hien TT, Hung NT, Janisch T, Kroeger A, Lum LC, Martinez E, Siqueira JB, Thuy TT, Villalobos I, Villegas E, Wills B, , 2011. Multicentre prospective study on dengue classification in four south-east Asian and three Latin American countries. Trop Med Int Health 16: 936948.[Crossref]
  13. Trung DT, Thao le TT, Dung NM, Ngoc TV, Hien TT, Chau NV, Wolbers M, Tam DT, Farrar J, Simmons C, Wills B, , 2012. Clinical features of dengue in a large Vietnamese cohort: intrinsically lower platelet counts and greater risk for bleeding in adults than children. PLoS Negl Trop Dis 6: e1679.[Crossref]
  14. Wills B, Tran VN, Nguyen TH, Truong TT, Tran TN, Nguyen MD, Tran VD, Nguyen VV, Dinh TT, Farrar J, , 2009. Hemostatic changes in Vietnamese children with mild dengue correlate with the severity of vascular leakage rather than bleeding. Am J Trop Med Hyg 81: 638644.[Crossref]
  15. Ali N, Usman M, Syed N, Khurshid M, , 2007. Haemorrhagic manifestations and utility of haematological parameters in dengue fever: a tertiary care centre experience at Karachi. Scand J Infect Dis 39: 10251028.[Crossref]
  16. de Souza LJ, Nogueira RM, Soares LC, Soares CE, Ribas BF, Alves FP, Vieira FR, Pessanha FE, , 2007. The impact of dengue on liver function as evaluated by aminotransferase levels. Braz J Infect Dis 11: 407410.[Crossref]
  17. Trung DT, Thao le TT, Hien TT, Hung NT, Vinh NN, Hien PT, Chinh NT, Simmons C, Wills B, , 2010. Liver involvement associated with dengue infection in adults in Vietnam. Am J Trop Med Hyg 83: 774780.[Crossref]
  18. Coudeville L, Garnett GP, , 2012. Transmission dynamics of the four dengue serotypes in southern Vietnam and the potential impact of vaccination. PLoS ONE 7: e51244.[Crossref]
  19. Fox A, Le NM, Simmons CP, Wolbers M, Wertheim HF, Pham TK, Tran TH, Trinh TM, Nguyen TL, Nguyen VT, Nguyen DH, Farrar J, Horby P, Taylor WR, Nguyen VK, , 2011. Immunological and viral determinants of dengue severity in hospitalized adults in Ha Noi, Vietnam. PLoS Negl Trop Dis 5: e967.[Crossref]
  20. Ha DQ, Tien NT, Huong VT, Loan HT, Thang CM, , 2000. Dengue epidemic in southern Vietnam, 1998. Emerg Infect Dis 6: 422425.[Crossref]
  21. Tien NT, Luxemburger C, Toan NT, Pollissard-Gadroy L, Huong VT, Van Be P, Rang NN, Wartel TA, Lang J, , 2010. A prospective cohort study of dengue infection in schoolchildren in Long Xuyen, Vietnam. Trans R Soc Trop Med Hyg 104: 592600.[Crossref]
  22. Cuong HQ, Hien NT, Duong TN, Phong TV, Cam NN, Farrar J, Nam VS, Thai KT, Horby P, , 2011. Quantifying the emergence of dengue in Hanoi, Vietnam: 1998–2009. PLoS Negl Trop Dis 5: e1322.[Crossref]
  23. Goh KT, , 1997. Dengue—a re-emerging infectious disease in Singapore. Ann Acad Med Singapore 26: 664670.
  24. Cavalcanti LP, Vilar D, Souza-Santos R, Teixeira MG, , 2011. Change in age pattern of persons with dengue, northeastern Brazil. Emerg Infect Dis 17: 132134.[Crossref]
  25. World Health Organization, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Geneva, Switzerland: World Health Organization.
  26. Simmons CP, Popper S, Dolocek C, Chau TN, Griffiths M, Dung NT, Long TH, Hoang DM, Chau NV, Thao le TT, Hien TT, Relman DA, Farrar J, , 2007. Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever. J Infect Dis 195: 10971107.[Crossref]
  27. Laue T, Emmerich P, Schmitz H, , 1999. Detection of dengue virus RNA in patients after primary or secondary dengue infection by using the TaqMan automated amplification system. J Clin Microbiol 37: 25432547.
  28. Cardosa MJ, Wang SM, Sum MS, Tio PH, , 2002. Antibodies against prM protein distinguish between previous infection with xdengue and Japanese encephalitis viruses. BMC Microbiol 2: 9.[Crossref]
  29. Koraka P, Suharti C, Setiati TE, Mairuhu AT, Van Gorp E, Hack CE, Juffrie M, Sutaryo J, Van Der Meer GM, Groen J, Osterhaus AD, , 2001. Kinetics of dengue virus-specific serum immunoglobulin classes and subclasses correlate with clinical outcome of infection. J Clin Microbiol 39: 43324338.[Crossref]
  30. Whitehorn J, Farrar J, , 2011. Dengue. Clin Med 11: 483487.[Crossref]
  31. Whitehorn J, Rodriguez Roche R, Guzman MG, Martinez E, Gomez WV, Nainggolan L, Laksono IS, Mishra A, Lum L, Faiz A, Sall A, Dawurung J, Borges A, Leo YS, Blumberg L, Bausch DG, Kroeger A, Horstick O, Thwaites G, Wertheim H, Larsson M, Hien TT, Peeling R, Wills B, Simmons C, Farrar J, , 2012. Prophylactic platelets in dengue: survey responses highlight lack of an evidence base. PLoS Negl Trop Dis 6: e1716.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.14-0472
Loading
/content/journals/10.4269/ajtmh.14-0472
Loading

Data & Media loading...

Supplementary Data

Supplementary PDF

  • Received : 29 Jul 2014
  • Accepted : 14 Jan 2015

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error