1921
Volume 92, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Leptospirosis is a neglected zoonosis caused by pathogenic . In this study, we characterized the virulence of isolate B3-13S obtained from a wild mouse () captured in New Caledonia, subsequently identified as a bacterium belonging to the serogroup Ballum. Hamsters were infected with an intraperitoneal injection of 2 × 10 bacteria, resulting in severe histopathological organ damages consistent with tissue lesions previously observed with other strains. Hamsters were also injected with 1 × 10 or 5 × 10 bacteria and animals that recovered showed renal carriage of leptospires in concentrations similar to the bacterial load quantified in mouse kidneys, with urinary shedding of bacteria up to 4 weeks postinfection. The serogroup Ballum is increasingly reported in human leptospirosis, and these results highlight the use of the B3-13S isolate for the development of models resulting in either severe acute or chronic forms of the infection, allowing for better characterization of its pathogenesis.

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2015-05-06
2017-11-20
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  • Received : 24 Jul 2014
  • Accepted : 22 Jan 2015

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