Volume 92, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



A seropositive rate of 6.59% was determined in the highly endemic region for severe fever with thrombocytopenia syndrome. A significant correlation was observed between case incidence and seroprevalence on temporal and geographic levels. Seroprevalence was comparable in the last 3 years, indicating a stable and ongoing circulation of the infection.


Article metrics loading...

Loading full text...

Full text loading...



  1. Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, Zhang L, Zhang QF, Popov VL, Li C, Qu J, Li Q, Zhang YP, Hai R, Wu W, Wang Q, Zhan FX, Wang XJ, Kan B, Wang SW, Wan KL, Jing HQ, Lu JX, Yin WW, Zhou H, Guan XH, Liu JF, Bi ZQ, Liu GH, Ren J, Wang H, Zhao Z, Song JD, He JR, Wan T, Zhang JS, Fu XP, Sun LN, Dong XP, Feng ZJ, Yang WZ, Hong T, Zhang Y, Walker DH, Wang Y, Li DX, , 2011. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364: 15231532.[Crossref]
  2. Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T, Kamei T, Honda M, Ninomiya D, Sakai T, Senba T, Kaneyuki S, Sakaguchi S, Satoh A, Hosokawa T, Kawabe Y, Kurihara S, Izumikawa K, Kohno S, Azuma T, Suemori K, Yasukawa M, Mizutani T, Omatsu T, Katayama Y, Miyahara M, Ijuin M, Doi K, Okuda M, Umeki K, Saito T, Fukushima K, Nakajima K, Yoshikawa T, Tani H, Fukushi S, Fukuma A, Ogata M, Shimojima M, Nakajima N, Nagata N, Katano H, Fukumoto H, Sato Y, Hasegawa H, Yamagishi T, Oishi K, Kurane I, Morikawa S, Saijo M, , 2014. The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan. J Infect Dis 209: 816827.[Crossref]
  3. Kim KH, Yi J, Kim G, Choi SJ, Jun KI, Kim NH, Choe PG, Kim NJ, Lee JK, Oh MD, , 2013. Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis 19: 18921894.[Crossref]
  4. Denic S, Janbeih J, Nair S, Conca W, Tariq WU, Al-Salam S, , 2011. Acute thrombocytopenia, leucopenia, and multiorgan dysfunction: the first case of SFTS Bunyavirus outside China? Case Rep Infect Dis 2011: 204056.
  5. Zhang X, Liu Y, Zhao L, Li B, Yu H, Wen H, Yu XJ, , 2013. An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV. Sci China Life Sci 56: 697700.[Crossref]
  6. Huang X, Du Y, Hu X, Ma H, Wang H, You A, Kang K, Chen H, Zhang L, Liu G, Xu B, , 2014. Epidemiological and etiological characteristics of fever, thrombocytopenia and leukopenia syndrome in Henan Province, China, 2011–2012. PLoS ONE 9: e91166.[Crossref]
  7. Jiao Y, Zeng X, Guo X, Qi X, Zhang X, Shi Z, Zhou M, Bao C, Zhang W, Xu Y, Wang H, , 2012. Preparation and evaluation of recombinant severe fever with thrombocytopenia syndrome virus nucleocapsid protein for detection of total antibodies in human and animal sera by double-antigen sandwich enzyme-linked immunosorbent assay. J Clin Microbiol 50: 372377.[Crossref]
  8. Wen HL, Zhao L, Zhai S, Chi Y, Cui F, Wang D, Wang L, Wang Z, Wang Q, Zhang S, Liu Y, Yu H, Yu XJ, , 2014. Severe fever with thrombocytopenia syndrome, Shandong Province, China, 2011. Emerg Infect Dis 20: 15.[Crossref]
  9. Xing Z, Schefers J, Schwabenlander M, Jiao Y, Liang M, Qi X, Li C, Goyal S, Cardona CJ, Wu X, Zhang Z, Li D, Collins J, Murtaugh MP, , 2013. Novel bunyavirus in domestic and captive farmed animals, Minnesota, USA. Emerg Infect Dis 19: 14871489.[Crossref]
  10. Zheng WS, Zeng XY, Zhou MH, Jiao YJ, Wen T, Gou XL, Qi X, Shi ZY, , 2011. Seroepidemiology of severe fever with thrombocytopenia syndrome bunyavirus in Jiangsu province. Dis Surveill 26: 676678.
  11. Liu Q, He B, Huang SY, Wei F, Zhu XQ, , 2014. Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis. Lancet Infect Dis 14: 763772.[Crossref]
  12. Liu L, Guan XH, Xing XS, Sheng XF, Xu JQ, Yue JL, Huo XX, Sha S, Wu HX, Huang J, Jiang W, Ding F, Zhou H, Yin WW, Li Q, Liang MF, Zhan FX, , 2012. Epidemiologic analysis on severe fever with thrombocytopenia syndrom in Hubei Province, 2010. Chin J Epidemiol 33: 168172.
  13. Zhao L, Zhai S, Wen H, Cui F, Chi Y, Wang L, Xue F, Wang Q, Wang Z, Zhang S, Song Y, Du J, Yu XJ, , 2012. Severe fever with thrombocytopenia syndrome virus, Shandong Province, China. Emerg Infect Dis 18: 963965.[Crossref]

Data & Media loading...

Supplementary Data

Supplementary PDF

  • Received : 17 Jul 2014
  • Accepted : 24 Nov 2014

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error