Volume 92, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Yaws, a non-venereal treponemal disease, is targeted for eradication by 2020 but accurate epidemiological data to guide control programs remain sparse. The Solomon Islands reports the second highest number of cases of yaws worldwide. We conducted a cluster randomized survey of yaws in two provinces of the Solomon Islands. One thousand four hundred and ninety-seven (1,497) children 5–14 years of age were examined. Clinical signs of active yaws were found in 79 children (5.5%), whereas 140 children (9.4%) had evidence of healed yaws lesions. Four hundred and seventy (470) (31.4%) children had a positive particle agglutination assay (TPPA). Two hundred and eighty-five (285) children (19%) had a positive TPPA and rapid plasma regain assay. Risk of yaws increased with age and was more common in males. The prevalence of yaws at village level was the major risk factor for infection. Our findings suggest the village, not the household, should be the unit of treatment in the World Health Organization (WHO) yaws eradication strategy.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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  1. Castellani A, , 1905. On the presence of spirochaetes in two cases of ulcerated parangi (Yaws). BMJ 2: 1280. [Google Scholar]
  2. Cejková D, Zobaníková M, Chen L, Pospíšilová P, Strouhal M, Qin X, Mikalová L, Norris SJ, Muzny DM, Gibbs RA, Fulton LL, Sodergren E, Weinstock GM, Smajs D, , 2012. Whole genome sequences of three Treponema pallidum ssp. pertenue strains: yaws and syphilis treponemes differ in less than 0.2% of the genome sequence. PLoS Negl Trop Dis 6: e1471.[Crossref] [Google Scholar]
  3. Perine PL, Hopkins DR, Niemel PL, St. John RG, Antal G, , 1984. Handbook of Endemic Treponematoses : Yaws, Endemic Syphilis and Pinta. Geneva: World Health Organization. Available at: http://apps.who.int/iris/handle/10665/37178?locale=en. Accessed May 2, 2013. [Google Scholar]
  4. Hackett CJ, , 1953. Extent and nature of the yaws problem in Africa. Bull World Health Organ 8: 127182. [Google Scholar]
  5. Mitjà O, Asiedu K, Mabey D, , 2013. Yaws. Lancet 381: 763773.[Crossref] [Google Scholar]
  6. Eason RJ, Tasman-Jones T, , 1985. Resurgent yaws and other skin diseases in the Western Province of the Solomon Islands. P N G Med J 28: 247250. [Google Scholar]
  7. Manning LA, Ogle GD, , 2002. Yaws in the periurban settlements of Port Moresby, Papua New Guinea. P N G Med J 45: 206212. [Google Scholar]
  8. Fegan D, Glennon MJ, Thami Y, Pakoa G, , 2010. Resurgence of yaws in Tanna, Vanuatu: time for a new approach? Trop Doct 40: 6869.[Crossref] [Google Scholar]
  9. Gerstl S, Kiwila G, Dhorda M, Lonlas S, Myatt M, Ilunga BK, Lemasson D, Szumilin E, Guerin PJ, Ferradini L, , 2009. Prevalence study of yaws in the Democratic Republic of Congo using the lot quality assurance sampling method. PLoS ONE 4: e6338.[Crossref] [Google Scholar]
  10. Manirakiza A, Boas SV, Beyam N, Zadanga G, Konamna FX, Njuimo SP, Laganier R, , 2011. Clinical outcome of skin yaws lesions after treatment with benzathine benzylpenicillin in a pygmy population in Lobaye, Central African Republic. BMC Res Notes 4: 543.[Crossref] [Google Scholar]
  11. Mitjà O, Hays R, Ipai A, Penias M, Paru R, Fagaho D, de Lazzari E, Bassat Q, , 2012. Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomized trial. Lancet 379: 342347.[Crossref] [Google Scholar]
  12. The World Health Organization, 2012. Eradication of yaws: the Morges Strategy. Wkly Epidemiol Rec 87: 189194. [Google Scholar]
  13. Anselmi M, Araujo E, Narvaez A, Cooper PJ, Guderian RH, , 1995. Yaws in Ecuador: impact of control measures on the disease in the Province of Esmeraldas. Genitourin Med 71: 343346. [Google Scholar]
  14. Kabore A, Solomon AW, , 2013. Completing the Baseline Map of the Preventive-Chemotherapy Neglected Tropical Diseases (NTDs): The Global Trachoma Mapping Project and WHO's NTD Mapping Initiative. American Society of Tropical Medicine and Hygiene - 62nd Annual Meeting, Washington, DC, November 13–17. [Google Scholar]
  15. Pavluck A, Chu B, Mann Flueckiger R, Ottesen E, , 2014. Electronic data capture tools for global health programs: evolution of LINKS, an android-, web-based system. PLoS Negl Trop Dis 8: e2654.[Crossref] [Google Scholar]
  16. Mitjà O, Hays R, Ipai A, Gubaila D, Lelngei F, Kirara M, Paru R, Bassat Q, , 2011. Outcome predictors in treatment of yaws. Emerg Infect Dis 17: 10831085.[Crossref] [Google Scholar]
  17. Fegan D, Glennon M, Macbride-Stewart G, Moore T, , 1990. Yaws in the Solomon Islands. J Trop Med Hyg 93: 5257. [Google Scholar]
  18. McBride WJ, Hannah RC, Le Cornec GM, Bletchly C, , 2008. Cutaneous chancroid in a visitor from Vanuatu. Australas J Dermatol 49: 9899.[Crossref] [Google Scholar]
  19. Mitjà O, Lukehart SA, Pokowas G, Moses P, Kapa A, Godornes C, Robson J, Cherian S, Houinei W, Kazadi W, Siba P, de Lazzari E, Bassat Q, , 2014. Haemophilus ducreyi as a cause of skin ulcers in children from a yaws-endemic area of Papua New Guinea: a prospective cohort study. Lancet Glob Health 2: e235e241.[Crossref] [Google Scholar]
  20. Marks M, Chi KH, Vahi V, Pillay A, Sokana O, Pavluk A, Mabey DC, Chen CY, Solomon AW, , 2014. Haemophilus ducreyi associated with skin ulcers among children, Solomon Islands. Emerg Infect Dis 2014 Oct. Available at: http://dx.doi.org/10.3201/eid2010.140573. [Google Scholar]
  21. Wicher K, Wicher V, Abbruscato F, Baughn RE, , 2000. Treponema pallidum subsp. pertenue displays pathogenic properties different from those of T. pallidum subsp. pallidum. Infect Immun 68: 32193225.[Crossref] [Google Scholar]

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  • Received : 13 Jul 2014
  • Accepted : 16 Aug 2014
  • Published online : 07 Jan 2015

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