Volume 92, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Mayaro virus (MAYV) is widely distributed throughout South America and is the etiologic agent of Mayaro fever, an acute febrile illness often presenting with arthralgic manifestations. The true incidence of MAYV infection is likely grossly underestimated because the symptomatic presentation is very similar to that of dengue fever and other acute febrile tropical diseases. We report the complete genome sequence of a MAYV isolate detected from an Acrelândia patient presenting with fever, chills, and sweating, but with no arthralgia. Results show that this isolate belongs to genotype D and is closely related to Bolivian strains. Our results suggest that the Acre/Mayaro strain is closely related to the progenitor of these Bolivian strains that were isolated between 2002 and 2006.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Figueiredo LT, , 2007. Emergent arboviruses in Brazil. Rev Soc Bras Med Trop 40: 224229.[Crossref] [Google Scholar]
  2. Coimbra TL, Santos CL, Suzuki A, Petrella SM, Bisordi I, Nagamori AH, Marti AT, Santos RN, Fialho DM, Lavigne S, Buzzar MR, Rocco IM, , 2007. Mayaro virus: imported cases of human infection in Sao Paulo State, Brazil. Rev Inst Med Trop Sao Paulo 49: 221224.[Crossref] [Google Scholar]
  3. Silva-Nunes M, Malafronte R dos S, Luz B de A, Souza EA, Martins LC, Rodrigues SG, Chiang JO, Vasconcelos PF, Muniz PT, Ferreira MU, , 2006. The Acre Project: the epidemiology of malaria and arthropod-borne virus infections in a rural Amazonian population. Cad Saude Publica 22: 13251334.[Crossref] [Google Scholar]
  4. Tavares-Neto J, Freitas-Carvalho J, Nunes MR, Rocha G, Rodrigues SG, Damasceno E, Darub R, Viana S, Vasconcelos PF, , 2004. Serologic survey for yellow fever and other arboviruses among inhabitants of Rio Branco, Brazil, before and three months after receiving the yellow fever 17D vaccine. Rev Soc Bras Med Trop 37: 16.[Crossref] [Google Scholar]
  5. Vasconcelos PF, Travassos da Rosa AP, Rodrigues SG, Travassos da Rosa ES, Degallier N, Travassos da Rosa JF, , 2001. Inadequate management of natural ecosystem in the Brazilian Amazon region results in the emergence and reemergence of arboviruses. Cad Saude Publica 17 (Suppl): 155164.[Crossref] [Google Scholar]
  6. Vasconcelos PF, Travassos da Rosa AP, Pinheiro FP, Shope RE, Travassos da Rosa JF, Rodrigues SG, Dégallier N, Travassos da Rosa ES, Travassos da Rosa AP, Vasconcelos PF, Travassos da Rosa JF, , 1998. Arboviruses pathogenic for man in Brazil. , eds. An Overview of Arbovirology in Brazil and Neighbouring Countries. Belém: Evandro Chagas Institute, 7299. [Google Scholar]
  7. Pinheiro FP, Freitas RB, Travassos da Rosa JF, Gabbay YB, Mello WA, LeDuc JW, , 1981. An outbreak of Mayaro virus disease in Belterra, Brazil. I. Clinical and virological findings. Am J Trop Med Hyg 30: 674681. [Google Scholar]
  8. Pinheiro FP, LeDuc JW, Monath TP, , 1988. Mayaro virus disease. , ed. The Arboviruses: Epidemiology and Ecology. Boca Raton, FL: CRC Press, 13750. [Google Scholar]
  9. Theiler M, Downs WG, , 1973. The Arthropod-Borne Viruses of Vertebrates. New Haven, CT: Yale University Press. [Google Scholar]
  10. Long KC, Ziegler SA, Thangamani S, Hausser NL, Kochel TJ, Higgs S, Tesh RB, , 2011. Experimental transmission of Mayaro virus by Aedes aegypti . Am J Trop Med Hyg 85: 750757.[Crossref] [Google Scholar]
  11. Travassos da Rosa ATdR JF, Pinheiro FP, Vasconcelos PF, de Leão RN, , 1997. Arboviroses. , ed. Doenças Infecciosas e Parasitarias: Enfoque Amazônico. Belém: CEJUP, 20722. [Google Scholar]
  12. Anderson CR, Downs WG, Wattley GH, Ahin NW, Reese AA, , 1957. Mayaro virus: a new human disease agent. II. Isolation from blood of patients in Trinidad, B.W.I. Am J Trop Med Hyg 6: 10121016. [Google Scholar]
  13. Schaeffer M, Gajdusek DC, Lema AB, Eichesewald H, , 1959. Epidemic jungle fevers among Okinawan colonists in the Bolivian rain forest. I. Epidemiology. Am J Trop Med Hyg 8: 372396. [Google Scholar]
  14. Forshey BM, Guevara C, Laguna-Torres VA, Cespedes M, Vargas J, Gianella A, Vallejo E, Madrid C, Aguayo N, Gotuzzo E, Suarez V, Morales AM, Beingolea L, Reyes N, Perez J, Negrete M, Rocha C, Morrison AC, Russell KL, Blair PJ, Olson JG, Kochel TJ, Group NFSW, , 2010. Arboviral etiologies of acute febrile illnesses in Western South America, 2000–2007. PLoS Negl Trop Dis 4: e787.[Crossref] [Google Scholar]
  15. Talarmin A, Chandler LJ, Kazamji M, de Thoisy B, Debon P, Lelarge J, Labeau B, Bourreau E, Vié JC, Shope RE, Sarthou J-L, , 1981. Mayaro virus fever in French Guiana: isolation, identification and seroprevalence. Am Soc J Trop Med Hyg 59: 452456. [Google Scholar]
  16. Halsey ES, Siles C, Guevara C, Vilcarromero S, Jhonston EJ, Ramal C, Aguilar PV, Ampuero JS, , 2013. Mayaro virus infection, Amazon Basin region, Peru, 2010–2013. Emerg Infect Dis 19: 18391842.[Crossref] [Google Scholar]
  17. Munoz M, Navarro JC, , 2012. Mayaro: a re-emerging arbovirus in Venezuela and Latin America. Biomedica 32: 286302. [Google Scholar]
  18. Causey O, Maroja OM, , 1957. Mayaro virus: a new human disease agente. III. Investigation of an epidemic of acute febrile illnes on the River Guama in Pará, Brazil, and isolation of Mayaro virus as a causative agent. Am J Trop Med Hyg 6: 10171023. [Google Scholar]
  19. Mourao MP, Bastos M de S, de Figueiredo RP, Gimaque JB, Galusso E dos S, Kramer VM, de Oliveira CM, Naveca FG, Figueiredo LT, , 2012. Mayaro fever in the city of Manaus, Brazil, 2007–2008. Vector Borne Zoonotic Dis 12: 4246.[Crossref] [Google Scholar]
  20. Powers AM, Aguilar PV, Chandler LJ, Brault AC, Meakins TA, Watts D, Russell KL, Olson J, Vasconcelos PF, Da Rosa AT, Weaver SC, Tesh RB, , 2006. Genetic relationships among Mayaro and Una viruses suggest distinct patterns of transmission. Am J Trop Med Hyg 75: 461469. [Google Scholar]
  21. da Silva-Nunes M, de Souza VA, Pannuti CS, Speranca MA, Terzian AC, Nogueira ML, Yamamura AM, Freire MS, da Silva NS, Malafronte RS, Muniz PT, Vasconcelos HB, da Silva EV, Vasconcelos PF, Ferreira MU, , 2008. Risk factors for dengue virus infection in rural Amazonia: population-based cross-sectional surveys. Am J Trop Med Hyg 79: 485494. [Google Scholar]
  22. de Morais Bronzoni RV, Baleotti FG, Ribeiro Nogueira RM, Nunes M, Moraes Figueiredo LT, , 2005. Duplex reverse transcription-PCR followed by nested PCR assays for detection and identification of Brazilian alphaviruses and flaviviruses. J Clin Microbiol 43: 696702.[Crossref] [Google Scholar]
  23. Green MR, Sambrook J, , 2012. Molecular Cloning: A Laboratory Manual. New York: Cold Spring Harbor Laboratory Press. [Google Scholar]
  24. Huelsenbeck JP, Ronquist F, , 2001. MRBAYES: Bayesian inference of phylogenetic trees. Bioinformatics 17: 754755.[Crossref] [Google Scholar]
  25. Neumayr A, Gabriel M, Fritz J, Gunther S, Hatz C, Schmidt-Chanasit J, Blum J, , 2012. Mayaro virus infection in traveler returning from Amazon Basin, northern Peru. Emerg Infect Dis 18: 695696.[Crossref] [Google Scholar]
  26. Receveur MC, Grandadam M, Pistone T, Malvy D, , 2010. Infection with Mayaro virus in a French traveler returning from the Amazon region, Brazil, January, 2010. Euro Surveill 15: 19563. [Google Scholar]
  27. Hassing RJ, Leparc-Goffart I, Blank SN, Thevarayan S, Tolou H, van Doornum G, van Genderen PJ, , 2010. Imported Mayaro virus infection in The Netherlands. J Infect 61: 343345.[Crossref] [Google Scholar]
  28. Kuniholm MH, Wolfe ND, Huang CY, Mpoudi-Ngole E, Tamoufe U, LeBreton M, Burke DS, Gubler DJ, , 2006. Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults. Am J Trop Med Hyg 74: 10781083. [Google Scholar]

Data & Media loading...

  • Received : 04 Jul 2014
  • Accepted : 16 Sep 2014
  • Published online : 04 Feb 2015

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error