Volume 92, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Dengue fever (DF) is an important health issue in Colombia, but detailed information on economic costs to the healthcare system is lacking. Using information from official databases (2010–2012) and a face-to-face survey of 1,483 households with DF and dengue hemorrhagic fever (DHF) patients, we estimated the average cost per case. In 2010, the mean direct medical costs to the healthcare system per case of ambulatory DF, hospitalized DF, and DHF (in Colombian pesos converted to US dollars using the average exchange rate for 2012) were $52.8, $235.8, and $1,512.2, respectively. The mean direct non-medical costs to patients were greater ($29.7, $46.7, and $62.6, respectively) than the mean household direct medical costs ($13.3, $34.8, and $57.3, respectively). The average direct medical cost to the healthcare system of a case of ambulatory DF in 2010 was 57% of that in 2011. Our results highlight the high economic burden of the disease and could be useful for assigning limited health resources.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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  1. Schmidt AC, , 2010. Response to dengue fever—the good, the bad, and the ugly? N Engl J Med 363: 484487.[Crossref] [Google Scholar]
  2. Guzman MG, Kouri G, , 2003. Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges. J Clin Virol 27: 113.[Crossref] [Google Scholar]
  3. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GR, Simmons CP, Scott TW, Farrar JJ, Hay SI, , 2013. The global distribution and burden of dengue. Nature 496: 504507.[Crossref] [Google Scholar]
  4. Gubler DJ, , 2002. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol 10: 100103.[Crossref] [Google Scholar]
  5. Martínez Torres E, , 2008. Dengue. Estud Av 22: 3352.[Crossref] [Google Scholar]
  6. Gubler DJ, , 1989. Aedes aegypti and Aedes aegypti-borne disease control in the 1990s: top down or bottom up. Charles Franklin Craig Lecture. Am J Trop Med Hyg 40: 571578. [Google Scholar]
  7. San Martín JL, Brathwaite O, Zambrano B, Solórzano JO, Bouckenooghe A, Dayan GH, Guzmán MG, , 2010. The epidemiology of dengue in the Americas over the last three decades: a worrisome reality. Am J Trop Med Hyg 82: 128135.[Crossref] [Google Scholar]
  8. Padilla JC, Rojas DP, Sáenz-Gómez R, , 2012. Dengue en Colombia: epidemiología de la reemergencia a la hiperendemia. Bogotá, Colombia: Universidad del Rosario. [Google Scholar]
  9. Zea D, Osorio L, , 2011. The status of the dengue surveillance system in a Colombian municipality. Rev Salud Publica (Bogota) 13: 785795.[Crossref] [Google Scholar]
  10. Castañeda-Orjuela C, Díaz H, Alvis-Guzman N, Olarte A, Rodriguez H, Camargo G, De la Hoz-Restrepo F, , 2012. Burden of disease and economic impact of dengue and severe dengue in Colombia, 2011. Value Health Reg Issues 1: 123128.[Crossref] [Google Scholar]
  11. Shepard DS, Coudeville L, Halasa YA, Zambrano B, Dayan GH, , 2011. Economic impact of dengue illness in the Americas. Am J Trop Med Hyg 84: 200207.[Crossref] [Google Scholar]
  12. Vargas-Zea N, Castro H, Rodríguez-Páez F, Téllez D, Salazar-Arias R, , 2012. Colombian health system on its way to improve allocation efficiency—transition from a health sector reform to the settlement of an HTA agency. Value Health Reg Issues 1: 218222.[Crossref] [Google Scholar]
  13. Kuno G, , 1995. Review of the factors modulating dengue transmission. Epidemiol Rev 17: 321335.[Crossref] [Google Scholar]
  14. Ministerio de la Protección Social, República de Colombia, 2010. Guía para la Atención Clínica Integral del Paciente con Dengue. Available at: http://www.minsalud.gov.co/Documentos%20y%20Publicaciones/Gu%C3%ADa%20para%20la%20atenci%C3%B3n%20cl%C3%ADnica%20integral%20del%20paciente%20con%20dengue.pdf. Accessed October 20, 2013. [Google Scholar]
  15. Campbell MK, Torgerson DJ, , 1999. Bootstrapping: estimating confidence intervals for cost-effectiveness ratios. QJM 92: 177182.[Crossref] [Google Scholar]
  16. Suaya JA, Shepard DS, Siqueira JB, Martelli CT, Lum LC, Tan LH, Kongsin S, Jiamton S, Garrido F, Montoya R, Armien B, Huy R, Castillo L, Caram M, Sah BK, Sughayyar R, Tyo KR, Halstead SB, , 2009. Cost of dengue cases in eight countries in the Americas and Asia: a prospective study. Am J Trop Med Hyg 80: 846855. [Google Scholar]
  17. Guzmán MG, Triana C, Bravo J, Kourí G, , 1992. The estimation of the economic damages caused as a consequence of the epidemic of hemorrhagic dengue in Cuba in 1981. Rev Cubana Med Trop 44: 1317. [Google Scholar]
  18. Von Allmen SD, López-Correa RH, Woodall JP, Morens DM, Chiriboga J, Casta-Velez A, , 1979. Epidemic dengue fever in Puerto Rico, 1977: a cost analysis. Am J Trop Med Hyg 28: 10401044. [Google Scholar]
  19. Chaparro P, Padilla J, Vallejo AF, Herrera S, , 2013. Characterization of a malaria outbreak in Colombia in 2010. Malar J 12: 330.[Crossref] [Google Scholar]
  20. Hales S, Weinstein P, Souares Y, Woodward A, , 1999. El Niño and the dynamics of vectorborne disease transmission. Environ Health Perspect 107: 99102. [Google Scholar]
  21. Armien B, Suaya JA, Quiroz E, Sah BK, Bayard V, Marchena L, Campos C, Shepard DS, , 2008. Clinical characteristics and national economic cost of the 2005 dengue epidemic in Panama. Am J Trop Med Hyg 79: 364371. [Google Scholar]

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Supplementary PDF

  • Received : 23 Jun 2014
  • Accepted : 04 Dec 2014
  • Published online : 01 Apr 2015

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