1921
Volume 91, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Implementation of mass drug administration for lymphatic filariasis (LF) has been delayed in central Africa because of incomplete mapping and coendemic loiasis. We mapped two regions in eastern Democratic Republic of Congo that were suspected to have LF. Night blood samples were collected from 2,724 subjects in 30 villages. Filarial antigenemia rates by card test exceeded 1% in 28 villages (range = 0–14%). Prevalence rates for large sheathed microfilariae (Mf) ranged from 4% to 40%; rates ranged from 22% to 98%. Large Mf were exclusively by microscopy, and only 1 of 337 samples tested by quantitative polymerase chain reaction (qPCR) was positive for DNA. Filarial antigen positivity was strongly associated with high Mf counts. Periodicity studies revealed atypical patterns, with no significant diurnal periodicity in some individuals. Thus, methods routinely used for LF mapping may not be reliable in areas in central Africa that are highly endemic for loiasis.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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References

  1. WHO, 2011. The Global Programme to Eliminate Lymphatic Filariasis: Progress Report 2000–2009 and Strategic Plan 2010–2020. Geneva: World Health Organization, 178. [Google Scholar]
  2. Simonsen PE, Fischer PU, Hoerauf A, Weil GJ, Farrar J, Hotez PJ, Junghanss T, Kang G, Lalloo D, White NJ, , 2014. The filariases. , eds. Manson's Tropical Diseases. Philadelphia, PA: Elsevier Saunders, 737765.[Crossref] [Google Scholar]
  3. Price DL, Mann GV, Roels OA, Merrill JM, , 1963. Parasitism in Congo pygmies. Am J Trop Med Hyg 12: 383387. [Google Scholar]
  4. Tekle AH, Zoure H, Wanji S, Leak S, Noma M, Remme JH, Amazigo U, , 2011. Integrated rapid mapping of onchocerciasis and loiasis in the Democratic Republic of Congo: impact on control strategies. Acta Trop 120 (Suppl 1): S81S90.[Crossref] [Google Scholar]
  5. Gass K, Beau de Rochars MV, Boakye D, Bradley M, Fischer PU, Gyapong J, Itoh M, Ituaso-Conway N, Joseph H, Kyelem D, Laney SJ, Legrand AM, Liyanage TS, Melrose W, Mohammed K, Pilotte N, Ottesen EA, Plichart C, Ramaiah K, Rao RU, Talbot J, Weil GJ, Williams SA, Won KY, Lammie P, , 2012. A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis. PLoS Negl Trop Dis 6: e1479.[Crossref] [Google Scholar]
  6. Rao RU, Atkinson LJ, Ramzy RM, Helmy H, Farid HA, Bockarie MJ, Susapu M, Laney SJ, Williams SA, Weil GJ, , 2006. A real-time PCR-based assay for detection of Wuchereria bancrofti DNA in blood and mosquitoes. Am J Trop Med Hyg 74: 826832. [Google Scholar]
  7. Fink DL, Kamgno J, Nutman TB, , 2011. Rapid molecular assays for specific detection and quantitation of Loa microfilaremia. PLoS Negl Trop Dis 5: e1299.[Crossref] [Google Scholar]
  8. R Core Team, 2013. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing. [Google Scholar]
  9. Venables WN, Ripley BD, , 2002. Modern Applied Statistics with S. New York, NY: Springer.[Crossref] [Google Scholar]
  10. Becker RA, Wilks AR, Brownrigg R, Minka TP, , 2013. maps: Draw Geographical Maps. Available at: cran.r-project.org/web/packages/maps/maps.pdf. [Google Scholar]
  11. Becker RA, Allen RW, Brownrigg R, , 2013. mapdata: Extra Map Databased. Available at: cran.r-project.org/web/packages/mapdata/mapdata/pdf. [Google Scholar]
  12. Simonsen PE, Magesa SM, , 2004. Observations on false positive reactions in the rapid NOW filariasis card test. Trop Med Int Health 9: 12001202.[Crossref] [Google Scholar]
  13. Zoure HG, Wanji S, Noma M, Amazigo UV, Diggle PJ, Tekle AH, Remme JH, , 2011. The geographic distribution of Loa in Africa: results of large-scale implementation of the rapid assessment procedure for loiasis (RAPLOA). PLoS Negl Trop Dis 5: e1210.[Crossref] [Google Scholar]
  14. Wanji S, Akotshi DO, Mutro MN, Tepage F, Ukety TO, Diggle PJ, Remme JH, , 2012. Validation of the rapid assessment procedure for loiasis (RAPLOA) in the Democratic Republic of Congo. Parasit Vectors 5: 25.[Crossref] [Google Scholar]
  15. Weil GJ, Curtis KC, Fakoli L, Fischer K, Gankpala L, Lammie PJ, Majewski AC, Pelletreau S, Won KY, Bolay FK, Fischer PU, , 2013. Laboratory and field evaluation of a new rapid test for detecting Wuchereria bancrofti antigen in human blood. Am J Trop Med Hyg 89: 1115.[Crossref] [Google Scholar]
  16. Weil GJ, Jain DC, Santhanam S, Malhotra A, Kumar H, Sethumadhavan KV, Liftis F, Ghosh TK, , 1987. A monoclonal antibody-based enzyme immunoassay for detecting parasite antigenemia in bancroftian filariasis. J Infect Dis 156: 350355.[Crossref] [Google Scholar]
  17. Weil GJ, Lammie PJ, Weiss N, , 1997. The ICT Filariasis Test: a rapid-format antigen test for diagnosis of bancroftian filariasis. Parasitol Today 13: 401404.[Crossref] [Google Scholar]
  18. Richards FO, Eigege A, Miri ES, Kal A, Umaru J, Pam D, Rakers LJ, Sambo Y, Danboyi J, Ibrahim B, Adelamo SE, Ogah G, Goshit D, Oyenekan OK, Mathieu E, Withers PC, Saka YA, Jiya J, Hopkins DR, , 2011. Epidemiological and entomological evaluations after six years or more of mass drug administration for lymphatic filariasis elimination in Nigeria. PLoS Negl Trop Dis 5: e1346.[Crossref] [Google Scholar]
  19. Shiferaw W, Kebede T, Graves PM, Golasa L, Gebre T, Mosher AW, Tadesse A, Sime H, Lambiyo T, Panicker KN, Richards FO, Hailu A, , 2012. Lymphatic filariasis in western Ethiopia with special emphasis on prevalence of Wuchereria bancrofti antigenaemia in and around onchocerciasis endemic areas. Trans R Soc Trop Med Hyg 106: 117127.[Crossref] [Google Scholar]
  20. Weil GJ, Chandrashekar R, Liftis F, McVay CS, Bosshardt SC, Klei TR, , 1990. Circulating parasite antigen in Brugia pahangi-infected jirds. J Parasitol 76: 7884.[Crossref] [Google Scholar]
  21. Weil GJ, Malane MS, Powers KG, Blair LS, , 1985. Monoclonal antibodies to parasite antigens found in the serum of Dirofilaria immitis-infected dogs. J Immunol 134: 11851191. [Google Scholar]
  22. Gardon J, Gardon-Wendel N, Demanga N, Kamgno J, Chippaux JP, Boussinesq M, , 1997. Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa infection. Lancet 350: 1822.[Crossref] [Google Scholar]
  23. Steel C, Golden A, Kubofcik J, LaRue N, de Los Santos T, Domingo GJ, Nutman TB, , 2013. Rapid Wuchereria bancrofti-specific antigen Wb123-based IgG4 immunoassays as tools for surveillance following mass drug administration programs on lymphatic filariasis. Clin Vaccine Immunol 20: 11551161.[Crossref] [Google Scholar]
  24. Supali T, Ismid IS, Wibowo H, Djuardi Y, Majawati E, Ginanjar P, Fischer P, , 2006. Estimation of the prevalence of lymphatic filariasis by a pool screen PCR assay using blood spots collected on filter paper. Trans R Soc Trop Med Hyg 100: 753759.[Crossref] [Google Scholar]
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Supplementary PDF

  • Received : 09 Jun 2014
  • Accepted : 28 Jul 2014
  • Published online : 03 Dec 2014

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