Volume 92, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Dengue is an acute febrile illness caused by any of four mosquito-transmitted dengue virus (DENV) types. Dengue is endemic in Jamaica, where an epidemic occurred in 2012. An investigation was conducted by multiple agencies for 66 missionaries traveling from nine US states to Jamaica after 1 missionary from the group was confirmed to have dengue. Travelers were offered diagnostic testing, and a survey was administered to assess knowledge, behaviors, and illness. Of 42 survey respondents, 9 (21%) respondents reported an acute febrile illness during or after travel to Jamaica. Of 15 travelers that provided serum specimens, 4 (27%) travelers had detectable anti-DENV immunoglobulin M antibody, and 1 traveler also had DENV-1 detected by reverse transcriptase polymerase chain reaction. Recent or past infection with a DENV was evident in 93% (13 of 14) missionaries with available sera. No behavioral or demographic factors were significantly associated with DENV infection. This investigation shows that even trips of short duration to endemic areas present a risk of acquiring dengue.


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  1. Leder K, Torresi J, Libman MD, Cramer JP, Castelli F, Schlagenhauf P, Wilder-Smith A, Wilson ME, Keystone JS, Schwartz E, Barnett ED, von Sonnenburg F, Brownstein JS, Cheng AC, Sotir MJ, Esposito DH, Freedman DO; GeoSentinel Surveillance Network, 2013. GeoSentinel surveillance of illness in returned traveler, 2007–2011. Ann Intern Med 158: 456468.[Crossref]
    [Google Scholar]
  2. Sharp TM, Pillai P, Hunsperger E, Santiago GA, Anderson T, Vap T, Collinson J, Buss BF, Safranek TJ, Sotir MJ, Jentes ES, Munoz-Jordan JL, Arguello DF, 2012. A cluster of dengue cases in American missionaries returning from Haiti, 2010. Am J Trop Med Hyg 86: 1622.[Crossref]
    [Google Scholar]
  3. Pan American Health Organization Wkly Epidemiol Rep, 2012. Number of reported cases of dengue and severe dengue (SD) in the Americas, by country - 15 December 2012 (EW 48). Available at: http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&gid=19582&Itemid=2518.
  4. Lombardo J, Burkom H, Elbert E, Magruder S, Lewis SH, Loschen W, Sari J, Sniegoski C, Wojcik R, Pavlin J, 2003. A systems overview of the Electronic Surveillance System for the Early Notification of Community-Based Epidemics (ESSENCE II). J Urban Health 80 (2 Suppl 1): i32i42.
    [Google Scholar]
  5. Santiago GA, Vergne E, Quiles Y, Cosme J, Vazquez J, Medina JF, Medina F, Colon C, Margolis H, Munoz-Jordan JL, 2013. Analytical and clinical performance of the CDC real time RT-PCR assay for detection and typing of dengue virus. PLoS Negl Trop Dis 7: e2311.[Crossref]
    [Google Scholar]
  6. Vorndam V, Beltran M, 2002. Enzyme-linked immunosorbent assay-format microneutralization test for dengue viruses. Am J Trop Med Hyg 66: 208212.
    [Google Scholar]
  7. World Health Organization, 2009. Dengue Guidelines for Diagnosis, Treatment, Prevention, and Control. Geneva: World Health Organization.
    [Google Scholar]
  8. Lyerla R, Rigau-Perez JG, Vorndam AV, Reiter P, George AM, Potter IM, Gubler DJ, 2000. A dengue outbreak among camp participants in a Caribbean island, 1995. J Travel Med 7: 5963.[Crossref]
    [Google Scholar]
  9. Centers for Disease C, 2010. Prevention: dengue fever among U.S. travelers returning from the Dominican Republic - Minnesota and Iowa, 2008. MMWR Morb Mortal Wkly Rep 59: 654656.
    [Google Scholar]
  10. Guzman MG, Alvarez M, Halstead SB, 2013. Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection. Arch Virol 158: 14451459.[Crossref]
    [Google Scholar]

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  • Received : 31 May 2014
  • Accepted : 05 Aug 2014
  • Published online : 07 Jan 2015
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