Volume 92, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The mosquito is the major vector of the four serotypes of dengue virus (DENV1–4). Previous studies have shown that in Mexico have a high effective migration rate and that gene flow occurs among populations that are up to 150 km apart. Since 2000, pyrethroids have been widely used for suppression of in cities in Mexico. In Yucatan State in particular, pyrethroids have been applied in and around dengue case households creating an opportunity for local selection and evolution of resistance. Herein, we test for evidence of local adaptation by comparing patterns of variation among 27 collections at 13 single nucleotide polymorphisms (SNPs): two in the voltage-gated sodium channel gene known to confer knockdown resistance, three in detoxification genes previously associated with pyrethroid resistance, and eight in putatively neutral loci. The SNPs in varied greatly in frequency among collections, whereas SNPs at the remaining 11 loci showed little variation supporting previous evidence for extensive local gene flow. Among in Yucatan State, Mexico, local adaptation to pyrethroids appears to offset the homogenizing effects of gene flow.


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Supplementary PDF

  • Received : 04 May 2014
  • Accepted : 18 Sep 2014
  • Published online : 07 Jan 2015

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