Volume 92, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Atovaquone-proguanil (AP) and artemether-lumefantrine (AL) are both treatments for uncomplicated malaria, but comparative clinical trials are lacking. We performed a retrospective analysis, comparing treatment failure and fever clearance time in non-immune travelers with uncomplicated malaria, treated with AP or AL. Sixty-nine patients were included during 2001–2013: 44 in the AP group and 25 in the AL group. Treatment failure was observed in 6 of 44 (13.6%) and 1 of 25 (4.0%) patients in the AP and AL groups, respectively. Six treatment failures were observed in travelers from West Africa. Fever clearance time was 44 ± 23 h in AL group versus 77 ± 28 h in AP group, ( < 0.001). Hospitalization time was significantly shorter in the AL group; 3.8 + 1.3 versus 5.1 + 2.8 days in the AP group ( = 0.04) In conclusion, travelers with uncomplicated malaria recover faster on AL than on AP. The AL should probably be the drug of choice for this population.


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  • Received : 23 Apr 2014
  • Accepted : 11 Jun 2014
  • Published online : 07 Jan 2015

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