1921
Volume 92, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Autochthonous transmission of in the United States is rarely reported. Here, we describe five newly identified patients with autochthonously acquired infections from a small pilot study of positive blood donors in southeast Texas. Case-patients 1–4 were possibly infected near their residences, which were all in the same region ∼100 miles west of Houston. Case-patient 5 was a young male with considerable exposure from routine outdoor and camping activities associated with a youth civic organization. Only one of the five autochthonous case-patients received anti-parasitic treatment. Our findings suggest an unrecognized risk of human vector-borne transmission in southeast Texas. Education of physicians and public health officials is crucial for identifying the true disease burden and source of infection in Texas.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.14-0238
2015-02-04
2017-11-23
Loading full text...

Full text loading...

/deliver/fulltext/14761645/92/2/325.html?itemId=/content/journals/10.4269/ajtmh.14-0238&mimeType=html&fmt=ahah

References

  1. Rassi A, Jr Rassi A, Marin-Neto JA, , 2010. Chagas disease. Lancet 375: 13881402.[Crossref]
  2. Sabino EC, Riberio AL, Salemi VM, Di Lorenzo Oliveria C, Antunes AP, Menezez MM, Ianni BM, Nastari L, Fernandes F, Patavino GM, Sachdev V, Capuani L, de Almeida-Neto C, Carrick DM, Wright D, Kavounis K, Goncalez TT, Carneiro-Proietti AB, Custer B, Busch MP, Murphy EL, National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study-II (REDS-II), International Component; , 2013. Ten-year incidence of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi-seropositive former blood donors. Circulation 127: 11051115.[Crossref]
  3. Jackson Y, Chatelain E, Mauris A, Holst M, Miao Q, Chappuis F, , 2013. Serological and parasitological response in chronic Chagas patients 3 years after nifurtimox treatment. BMC Infect Dis 13: 85.[Crossref]
  4. Pinazo MJ, Munoz J, Posada E, Lopez-Chejade P, Gallego M, Ayala E, del Cacho E, Soy D, Gascon J, , 2010. Tolerance of benznidazole in treatment of Chagas disease in adults. Antimicrob Agents Chemother 54: 48964899.[Crossref]
  5. Kirchhoff LV, , 1993. American trypanosomiasis (Chagas' disease)—a tropical disease now in the United States. N Engl J Med 329: 639644.[Crossref]
  6. Sarkar S, Strutz SE, Frank DM, Rivaldi CL, Sissel B, Sanchez-Cordero V, , 2010. Chagas disease risk in Texas. PLOS NTDs 4: e836.
  7. Kjos SA, Marcet PL, Yabsley MJ, Kitron U, Snowden KF, Logan KS, Barnes JC, Doston EM, , 2013. Identification of bloodmeal sources and Trypanosoma cruzi infection in triatomine bugs (Hemiptera: Reduviidae) from residential settings in Texas, the United States. J Med Entomol 50: 11261139.[Crossref]
  8. Woody NC, Woody HB, , 1955. American trypanosomiasis (Chagas' disease); first indigenous case in the United States. JAMA 159: 676677.[Crossref]
  9. Beard CB, Pye G, Steurer FJ, Rodriguez R, Campman R, Peterson AT, Ramsey J, Wirtz RA, Robinson LE, , 2003. Chagas disease in a domestic transmission cycle, southern Texas, USA. Emerg Infect Dis 9: 103105.[Crossref]
  10. Garcia MN, Woc-Colburn L, Rossmann SN, Townsend RL, Stramer SL, Bravo M, Kamel H, Beddard R, Townsend M, Oldham R, Bottazzi ME, Hotez PJ, Murray KO, , 2014. Trypanosoma cruzi screening in Texas blood donors, 2008–2012. Epidemiol Infect. doi:http://dx.doi.org/10.1017/S0950268814002234. Published online: 28 August 2014.
  11. Texas Department of State Health Services, 2014. Texas Notifiable Conditions. Available at: http://www.dshs.state.tx.us/idcu/investigation/conditions/contacts/. Accessed March 25, 2014.
  12. Cantey PT, Stramer SL, Townsend RL, Kamel H, Ofafa K, Todd CW, Currier M, Hand S, Varnado W, Dotson E, Hall C, Jett PL, Montgomery SP, , 2012. The United States Trypanosoma cruzi infection study: evidence for vector-borne transmission of the parasite that causes Chagas disease among United States blood donors. Transfusion 52: 19221930.[Crossref]
  13. Bern C, Montogomery SP, , 2009. An estimate of the burden of Chagas disease. Clin Infect Dis 49: e52e54.[Crossref]
  14. Garcia MN, Murray KO, Hotez PJ, Rossmann SN, Gorchakov R, Ontiveros A, Woc-Colburn L, Bottazzi ME, Rhodes CE, Ballantyne CM, Aguilar D, , 2014. Development of Chagas cardiac manifestations among Texas blood donors. Am J Cardiol 115: 113117.[Crossref]
  15. Custer B, Agapova M, Bruhn R, Cusick R, Kamel H, Tomasulo P, Biswas H, Tobler L, Lee TH, Caglioti S, Busch M, , 2012. Epidemiologic and laboratory findings from 3 years of testing United States blood donors for Trypanosoma cruzi . Transfusion 52: 19011911.[Crossref]
  16. Wilson LS, Ramsey JM, Koplowicz YB, Valiente-Banuet L, Motter C, Bertozzi SM, Tobler LH, , 2008. Cost-effectiveness of implementation methods for ELISA serology testing of Trypanosoma cruzi in California blood banks. Am J Trop Med Hyg 79: 5368.
  17. Leiby DA, Read EJ, Lenes BA, Yund AJ, Stumpf RJ, Kirchhoff LV, Dodd RY, , 1997. Seroepidemiology of Trypanosoma cruzi, etiologic agent of Chagas disease, in US blood donors. J Infect Dis 176: 10471052.[Crossref]
  18. O'Brien SF, Chiavetta JA, Fan W, Xi G, Yi QL, Goldman M, Scalia V, Fearon MA, , 2008. Assessment of a travel question to identify donors with risk of Trypanosoma cruzi: operational validity and field testing. Transfusion 48: 755761.[Crossref]
  19. Garcia MN, Hotez PJ, Murray KO, , 2014. Potential novel risk factors for autochthonous and sylvatic transmission of human Chagas disease in the United States. Parasit Vectors 7: 311.[Crossref]
  20. Edwards MS, Rench MA, Todd CW, Czaicki N, Steurer FJ, Bern C, Montgomery SP, , 2013. Perinatal screening for Chagas disease in southern Texas. J Ped Infect Dis 14. Available at: http://jpids.oxfordjournals.org/content/early/2013/10/03/jpids.pit056.1.full.pdf+html?sid=f876a11f-40f5-44d5-91e0-219c6e0f257f.
  21. Di Pentima MC, Hwang LY, Skeeter CM, Edwards MS, , 1999. Prevalence of antibody to Trypanosoma cruzi in pregnant Hispanic women in Houston. Clin Infect Dis 28: 12811285.[Crossref]
  22. Stimpert KK, Montgomery SP, , 2010. Physician awareness of Chagas disease, USA. Emerg Infect Dis 16: 871872.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.14-0238
Loading
/content/journals/10.4269/ajtmh.14-0238
Loading

Data & Media loading...

  • Received : 16 Apr 2014
  • Accepted : 10 Oct 2014

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error