Volume 92, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Leptospirosis is a common disease in tropical countries, and the kidney is one of the main target organs. Membrane proteins of are capable of causing endothelial damage , but there have been no studies in humans evaluating endothelial glycocalyx damage and its correlation with acute kidney injury (AKI). We performed a cohort study in an outbreak of leptospirosis among military personnel. AKI was diagnosed in 14 of 46 (30.4%) patients. Leptospirosis was associated with higher levels of intercellular adhesion molecule-1 (ICAM-1; 483.1 ± 31.7 versus 234.9 ± 24.4 mg/L, < 0.001) and syndecan-1 (73.7 ± 15.9 versus 21.2 ± 7.9 ng/mL, < 0.001) compared with exposed controls. Patients with leptospirosis-associated AKI had increased level of syndecan-1 (112.1 ± 45.4 versus 41.5 ± 11.7 ng/mL, = 0.021) and ICAM-1 (576.9 ± 70.4 versus 434.9 ± 35.3, = 0.034) compared with leptospirosis patients with no AKI. Association was verified between syndecan-1 and ICAM-1 with serum creatinine elevation and neutrophil gelatinase-associated lipocalin (NGAL) levels. This association remained even after multivariate analysis including other AKI-associated characteristics. Endothelial injury biomarkers are associated with leptospirosis-associated renal damage.


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  • Received : 14 Apr 2014
  • Accepted : 29 Oct 2014
  • Published online : 04 Mar 2015

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