1921
Volume 92, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Dengue is a potentially fatal acute febrile illness caused by the mosquito-borne dengue viruses (DENV-1 to -4). To estimate DENV seroincidence in school-aged children, a 1-year prospective cohort study was conducted in Patillas, Puerto Rico; 10- to 18-year-olds ( = 345) were randomly selected from 13 public schools. At enrollment, 49.8% of the entire cohort had DENV immunoglobulin G (IgG) anti-DENV antibodies, and there were individuals with neutralizing antibodies specific to each of the four DENV. The mean age of participants with incident DENV infection was 13.4 years. The 1-year seroincidence rate was 5.6%, and 61.1% of infections were inapparent. Having IgG anti-DENV at enrollment was associated with seroincidence (risk ratio = 6.8). Acute febrile illnesses during the study period were captured by a fever diary and an enhanced and passive surveillance system in the municipios of Patillas and Guayama. In summary, at enrollment, nearly one-half of the participants had a prior DENV infection, with the highest incidence in the 10- to 11-year-olds, of which most were inapparent infections, and symptomatic infections were considered mild.

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2015-03-04
2017-09-20
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References

  1. World Health Organization (WHO), 2006. Scientific Working Group on Dengue: Meeting Report. Geneva: WHO.
  2. Rigau-Perez JG, Clark GG, Gubler DJ, Reiter P, Sanders EJ, Vorndam AV, , 1998. Dengue and dengue haemorrhagic fever. Lancet 352: 971977.[Crossref]
  3. Gubler DJ, Meltzer M, , 1999. Impact of dengue/dengue hemorrhagic fever on the developing world. Adv Virus Res 53: 3570 [Crossref]
  4. Halstead SB, , 2005. More dengue, more questions. Emerg Infect Dis 11: 740741.[Crossref]
  5. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GR, Simmons CP, Scott TW, Farrar JJ, Hay SI, , 2013. The global distribution and burden of dengue. Nature 496: 504507.[Crossref]
  6. Likosky WH, Calisher CH, Michelson AL, Correa-Coronas R, Henderson BE, Feldman RA, , 1973. An epidemiologic study of dengue type 2 in Puerto Rico, 1969. Am J Epidemiol 97: 264275.[Crossref]
  7. Rigau-Perez JG, Vorndam AV, Clark GG, , 2001. The dengue and dengue hemorrhagic fever epidemic in Puerto Rico, 1994–1995. Am J Trop Med Hyg 64: 6774.
  8. Rigau-Perez JG, Ayala-Lopez A, Garcia-Rivera EJ, Hudson SM, Vorndam V, Reiter P, Cano MP, Clark GG, , 2002. The reappearance of dengue-3 and a subsequent dengue-4 and dengue-1 epidemic in Puerto Rico in 1998. Am J Trop Med Hyg 67: 355362.
  9. Tomashek KM, Rivera A, Muñoz-Jordan JL, Hunsperger E, Santiago L, Padro O, Garcia E, Sun W, , 2009. Description of a large island-wide outbreak of dengue in Puerto Rico, 2007. Am J Trop Med Hyg 81: 467474.
  10. Neff JM, Morris L, Gonzalez-Alcover R, Coleman PH, Lyss SB, Negron H, , 1967. Dengue fever in a Puerto Rican community. Am J Epidemiol 86: 162184.[Crossref]
  11. Waterman SH, Novak RJ, Sather GE, Bailey RE, Rios I, Gubler DJ, , 1985. Dengue transmission in two Puerto Rican communities in 1982. Am J Trop Med Hyg 34: 625632.
  12. Morens DM, Rigau-Perez JG, Lopez-Correa RH, Moore CG, Ruiz-Tiben EE, Sather GE, Chiriboga J, Eliason DA, Casta-Velez A, Woodall JP, , 1986. Dengue in Puerto Rico, 1977: public health response to characterize and control an epidemic of multiple serotypes. Am J Trop Med Hyg 35: 197211.
  13. Rodriguez-Figueroa L, Rigau-Perez JG, Suarez EL, Reiter P, , 1995. Risk factors for dengue infection during an outbreak in Yanes, Puerto Rico in 1991. Am J Trop Med Hyg 52: 496502.
  14. O'Leary DR, Rigau-Perez JG, Hayes EB, Vorndam AV, Clark GG, Gubler DJ, , 2002. Assessment of dengue risk in relief workers in Puerto Rico after Hurricane Georges, 1998. Am J Trop Med Hyg 66: 3539.
  15. Ramos MM, Arguello DF, Luxemburger C, Quinones L, Munoz JL, Beatty M, Lang J, Tomashek KM, , 2008. Epidemiological and clinical observations on patients with dengue in Puerto Rico: results from the first year of enhanced surveillance—June 2005–May 2006. Am J Trop Med Hyg 79: 123127.
  16. Martin DA, Muth DA, Brown T, Johnson AJ, Karabatsos N, Roehrig JT, , 2000. Standardization of immunoglobulin M capture enzyme-linked immunosorbent assays for routine diagnosis of arboviral infections. J Clin Microbiol 38: 18231826.
  17. Miagostovich MP, Nogueira RM, dos Santos FB, Schatzmayr HG, Araujo ES, Vorndam V, , 1999. Evaluation of an IgG enzyme-linked immunosorbent assay for dengue diagnosis. J Clin Virol 14: 183189.[Crossref]
  18. Vorndam V, Beltran M, , 2002. Enzyme-linked immunosorbent assay-format microneutralization test for dengue viruses. Am J Trop Med Hyg 66: 208212.
  19. World Health Organization (WHO), 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment, and Control. Geneva: WHO.
  20. Särndal C-E, Lundström S, , 2005. Estimation in Surveys with Nonresponse. West Sussex, England: Wiley.[Crossref]
  21. Rigau-Perez JG, Ayala-Lopez A, Vorndam AV, Clark GG, , 2001. Dengue activity in Puerto Rico during an interepidemic period (1995–1997). Am J Trop Med Hyg 64: 7583.
  22. Chappell WA, Calisher CH, Toole RF, Maness KC, Sasso DR, Henderson BE, , 1971. Comparison of three methods used to isolate dengue virus type 2. Appl Microbiol 22: 11001103.
  23. Gubler DJ, Kuno G, Sather GE, Velez M, Oliver A, , 1984. Mosquito cell-cultures and specific monoclonal-antibodies in surveillance for dengue viruses. Am J Trop Med Hyg 33: 158165.
  24. Sangkawibha N, Rojanasuphot S, Ahandrik S, Viriyapongse S, Jatanasen S, Salitul V, Phanthumachinda B, Halstead SB, , 1984. Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak. Am J Epidemiol 120: 653669.[Crossref]
  25. Burke DS, Nisalak A, Johnson DE, Scott RM, , 1988. A prospective study of dengue infections in Bangkok. Am J Trop Med Hyg 38: 172180.
  26. Thein S, Aung MM, Shwe TN, Aye M, Zaw A, Aye K, Aye KM, Aaskov J, , 1997. Risk factors in dengue shock syndrome. Am J Trop Med Hyg 56: 566572.
  27. Endy TP, Chunsuttiwat S, Nisalak A, Libraty DH, Green S, Rothman AL, Vaughn DW, Ennis FA, , 2002. Epidemiology of inapparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand. Am J Epidemiol 156: 4051.[Crossref]
  28. Yoon IK, Rothman AL, Tannitisupawong D, Srikiatkhachorn A, Jarman RG, Aldstadt J, Nisalak A, Mammen MP, Jr Thammapalo S, Green S, Libraty DH, Gibbons RV, Getis A, Endy T, Jones JW, Koenraadt CJ, Morrison AC, Fansiri T, Pimgate C, Scott TW, , 2012. Underrecognized mildly symptomatic viremic dengue virus infections in rural thai schools and villages. J Infect Dis 206: 389398.[Crossref]
  29. Balmaseda A, Hammond SN, Tellez Y, Imhoff L, Rodriguez Y, Saborio SI, Mercado JC, Perez L, Videa E, Almanza E, Kuan G, Reyes M, Saenz L, Amador JJ, Harris E, , 2006. High seroprevalence of antibodies against dengue virus in a prospective study of schoolchildren in Managua, Nicaragua. Trop Med Int Health 11: 935942.[Crossref]
  30. Thai KTD, Nga TTT, Van Nam N, Phuong HL, Giao PT, Hung LQ, Binh TQ, van Doornum GJJ, de Vries PJ, , 2007. Incidence of primary dengue virus infections in southern Vietnamese children and reactivity against other flaviviruses. Trop Med Int Health 12: 15531557.[Crossref]
  31. Balmaseda A, Standish K, Mercado JC, Matute JC, Tellez Y, Saborio S, Hammond SN, Nunez A, Aviles W, Henn MR, Holmes EC, Gordon A, Coloma J, Kuan G, Harris E, , 2010. Trends in patterns of dengue transmission over 4 years in a pediatric cohort study in Nicaragua. J Infect Dis 201: 514.[Crossref]
  32. Nguyen TKT, Luxemburger C, Nguyen TT, Pollissard-Gadroy L, Vu TQH, Pham VB, Nguyen NR, Wartel TA, Lang J, , 2010. A prospective cohort study of dengue infection in schoolchildren in Long Xuyen, Viet Nam. Trans R Soc Trop Med Hyg 104: 592600.[Crossref]
  33. Restrepo BN, Piedrahita LD, Agudelo IY, Parra-Henao G, Osorio JE, , 2012. Frequency and clinical features of dengue infection in a schoolchildren cohort from medellin, Colombia. J Trop Med 2012: 120496.[Crossref]
  34. Endy TP, Nisalak A, Chunsuttitwat S, Vaughn DW, Green S, Ennis FA, Rothman AL, Libraty DH, , 2004. Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand. J Infect Dis 189: 9901000.[Crossref]
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Supplementary Data

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  • Received : 14 Apr 2014
  • Accepted : 20 Nov 2014

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