1921
Volume 91, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Circulating levels of endothelial activation biomarkers are elevated in during infection with human immunodeficiency virus 1 (HIV-1) and may also be increased in Kaposi sarcoma (KS). We compared 23 HIV-1-seropositive women with clinically diagnosed KS with 46 randomly selected controls matched for visit year, CD4 count, and antiretroviral therapy status. Conditional logistic regression was used to identify differences between cases and controls. The odds of clinical KS increased with increasing plasma viral load and with intercellular adhesion molecule 1 (ICAM-1) levels above or equal to the median. There was a borderline association between increasing plasma angiopoietin 2 levels and KS. In multivariable modeling including plasma viral load, angiopoietin 2, and ICAM-1, plasma ICAM-1 levels above or equal to the median remained associated with clinical KS (odds ratio = 14.2, 95% confidence interval = 2.3–87.7). Circulating ICAM-1 levels should be evaluated as a potential biomarker for disease progression and treatment response among HIV-infected KS patients.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.14-0209
2014-10-01
2017-11-19
Loading full text...

Full text loading...

/deliver/fulltext/14761645/91/4/705.html?itemId=/content/journals/10.4269/ajtmh.14-0209&mimeType=html&fmt=ahah

References

  1. Braun-Falco O, Schmoeckel C, Hubner G, , 1976. The histogenesis of Kaposi sarcoma: a histochemical and electronmicroscopical study (in German). Virchows Arch A Pathol Anat Histol 369: 215227.[Crossref]
  2. Alessandri G, Fiorentini S, Licenziati S, Bonafede M, Monini P, Ensoli B, Caruso A, , 2003. CD8(+)CD28(−) T lymphocytes from HIV-1-infected patients secrete factors that induce endothelial cell proliferation and acquisition of Kaposi's sarcoma cell features. J Interferon Cytokine Res 23: 523531.[Crossref]
  3. Brown LF, Dezube BJ, Tognazzi K, Dvorak HF, Yancopoulos GD, , 2000. Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. Am J Pathol 156: 21792183.[Crossref]
  4. Graham SM, Rajwans N, Jaoko W, Estambale BB, McClelland RS, Overbaugh J, Liles WC, , 2013. Endothelial activation biomarkers increase after HIV-1 acquisition: plasma vascular cell adhesion molecule-1 predicts disease progression. AIDS 27: 18031813.[Crossref]
  5. Graham SM, Rajwans N, Tapia KA, Jaoko W, Estambale BB, McClelland RS, Overbaugh J, Liles WC, , 2013. A prospective study of endothelial activation biomarkers, including plasma angiopoietin-1 and angiopoietin-2, in Kenyan women initiating antiretroviral therapy. BMC Infect Dis 13: 263.[Crossref]
  6. Taylor JF, Smith PG, Bull D, Pike MC, , 1972. Kaposi's sarcoma in Uganda: geographic and ethnic distribution. Br J Cancer 26: 483497.[Crossref]
  7. Asiimwe F, Moore D, Were W, Nakityo R, Campbell J, Barasa A, Mermin J, Kaharuza F, , 2012. Clinical outcomes of HIV-infected patients with Kaposi's sarcoma receiving nonnucleoside reverse transcriptase inhibitor-based antiretroviral therapy in Uganda. HIV Med 13: 166171.
  8. GLOBOCAN, 2012. Estimated Cancer Incidence, Mortality, and Prevalence Worldwide in 2012. Available at: http://globocan.iarc.fr/Pages/fact_sheets_population.aspx. Accessed March 24, 2014.
  9. Maskew M, Fox MP, van Cutsem G, Chu K, Macphail P, Boulle A, Egger M, Africa FI, , 2013. Treatment response and mortality among patients starting antiretroviral therapy with and without Kaposi sarcoma: a cohort study. PLoS ONE 8: e64392.[Crossref]
  10. Martin HL, Jr Jackson DJ, Mandaliya K, Bwayo J, Rakwar JP, Nyange P, Moses S, Ndinya-Achola JO, Holmes K, Plummer F, , 1994. Preparation for AIDS vaccine evaluation in Mombasa, Kenya: establishment of seronegative cohorts of commercial sex workers and trucking company employees. AIDS Res Hum Retroviruses 10 (Suppl 2): S235S237.
  11. World Health Organization, 2010. Antiretroviral Therapy for HIV Infection in Adults and Adolescents: Recommendations for a Public Health Approach, 2010 Update. Geneva: World Health Organization.
  12. Emery S, Bodrug S, Richardson BA, Giachetti C, Bott MA, Panteleeff D, Jagodzinski LL, Michael NL, Nduati R, Bwayo J, Kreiss JK, Overbaugh J, , 2000. Evaluation of performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay using primary subtype A, C, and D isolates from Kenya. J Clin Microbiol 38: 26882695.
  13. Wang HW, Trotter MW, Lagos D, Bourboulia D, Henderson S, Mäkinen T, Elliman S, Flanagan AM, Alitalo K, Boshoff C, , 2004. Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet 36: 687693.[Crossref]
  14. Pati S, Cavrois M, Guo HG, Foulke JS, Jr Kim J, Feldman RA, Reitz M, , 2001. Activation of NF-kappaB by the human herpesvirus 8 chemokine receptor ORF74: evidence for a paracrine model of Kaposi's sarcoma pathogenesis. J Virol 75: 86608673.[Crossref]
  15. Kelly GD, Ensoli B, Gunthel CJ, Offermann MK, , 1998. Purified Tat induces inflammatory response genes in Kaposi's sarcoma cells. AIDS 12: 17531761.[Crossref]
  16. Offermann MK, Lin JC, Mar EC, Shaw R, Yang J, Medford RM, , 1996. Antioxidant-sensitive regulation of inflammatory-response genes in Kaposi's sarcoma cells. J Acquir Immune Defic Syndr Hum Retrovirol 13: 111.[Crossref]
  17. Galea P, Frances V, Dou-Dameche L, Sampol J, Chermann JC, , 1998. Role of Kaposi's sarcoma cells in recruitment of circulating leukocytes: implications in pathogenesis. J Hum Virol 1: 273281.
  18. Huang YQ, Friedman-Kien AE, Li JJ, Nickoloff BJ, , 1993. Cultured Kaposi's sarcoma cell lines express factor XIIIa, CD14, and VCAM-1, but not factor VIII or ELAM-1. Arch Dermatol 129: 12911296.[Crossref]
  19. Uccini S, Ruco LP, Monardo F, Stoppacciaro A, Dejana E, La Parola IL, Cerimele D, Baroni CD, , 1994. Co-expression of endothelial cell and macrophage antigens in Kaposi's sarcoma cells. J Pathol 173: 2331.[Crossref]
  20. Sciacca FL, Sturzl M, Bussolino F, Sironi M, Brandstetter H, Zietz C, Zhou D, Matteucci C, Peri G, Sozzani S, , 1994. Expression of adhesion molecules, platelet-activating factor, and chemokines by Kaposi's sarcoma cells. J Immunol 153: 48164825.
  21. Becker K, Heins M, Sudhoff T, Reinauer H, Haussinger D, , 1997. Specific pattern of circulating endothelial adhesion molecules in HIV-associated Kaposi's sarcoma. Int Arch Allergy Immunol 113: 512515.[Crossref]
  22. De Paoli P, Caffau C, D'Andrea M, Tavio M, Tirelli U, Santini G, , 1994. Serum levels of intercellular adhesion molecule 1 in patients with HIV-related Kaposi's sarcoma. J Acquir Immune Defic Syndr 7: 695659.
  23. Vart RJ, Nikitenko LL, Lagos D, Trotter MW, Cannon M, Bourboulia D, Gratrix F, Takeuchi Y, Boshoff C, , 2007. Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells. Cancer Res 67: 40424051.[Crossref]
  24. Ye FC, Zhou FC, Nithianantham S, Chandran B, Yu XL, Weinberg A, Gao SJ, , 2013. Kaposi's sarcoma-associated herpesvirus induces rapid release of angiopoietin-2 from endothelial cells. J Virol 87: 63266335.[Crossref]
  25. Dezube BJ, Sullivan R, Koon HB, , 2006. Emerging targets and novel strategies in the treatment of AIDS-related Kaposi's sarcoma: bidirectional translational science. J Cell Physiol 209: 659662.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.14-0209
Loading
/content/journals/10.4269/ajtmh.14-0209
Loading

Data & Media loading...

  • Received : 07 Apr 2014
  • Accepted : 03 Jun 2014

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error