Volume 92, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We report the first case of visceral leishmaniasis (VL) caused by in the Caribbean, which until now, was known only to cause cutaneous leishmaniasis. The disease presented with fatigue, anemia, and hepatosplenomegaly in a 61-year-old man with human immunodeficiency virus (HIV) infection who was receiving antiretroviral therapy. Diagnosis was made by bone marrow biopsy. VL is life-threatening, and its emergence in the Caribbean is of concern.


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  1. World Health Organization, 2007. Report of the Fifth Consultative Meeting on Leishmania/HIV Coinfection. Addis Ababa, Ethiopa: World Health Organization. [Google Scholar]
  2. Alvar J, Aparicio P, Aseffa A, Den Boer M, Canavate C, Dedet JP, Gradoni L, Ter Horst R, Lopez-Velez R, Moreno J, , 2008. The relationship between leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev 21: 334359.[Crossref] [Google Scholar]
  3. Dedet JP, Roche B, Pratlong F, Cales-Quist D, Jouannelle J, Benichou JC, Huerre M, , 1995. Diffuse cutaneous infection caused by a presumed monoxenous trypanosomatid in a patient infected with HIV. Trans R Soc Trop Med Hyg 89: 644646.[Crossref] [Google Scholar]
  4. Noyes H, Pratlong F, Chance M, Ellis J, Lanotte G, Dedet JP, , 2002. A previously unclassified trypanosomatid responsible for human cutaneous lesions in Martinique (French West Indies) is the most divergent member of the genus Leishmania ss. Parasitology 124: 1724. [Google Scholar]
  5. Desbois N, Pratlong F, Quist D, Dedet JP, , 2014. Leishmania (Leishmania) martiniquensis n. sp. (Kinetoplastida: Trypanosomatidae), description of the parasite responsible for cutaneous leishmaniasis in Martinique Island (French West Indies). Parasite 21: 12.[Crossref] [Google Scholar]
  6. Liautaud B, Pape JW, DeHovitz JA, Thomas F, LaRoche AC, Verdier RI, Deschamps MM, Johnson WD, , 1989. Pruritic skin lesions. A common initial presentation of acquired immunodeficiency syndrome. Arch Dermatol 125: 629632.[Crossref] [Google Scholar]
  7. Mary C, Faraut F, Lascombe L, Dumon H, , 2004. Quantification of Leishmania infantum DNA by a real-time PCR assay with high sensitivity. J Clin Microbiol 42: 52495255.[Crossref] [Google Scholar]
  8. Zeledon R, , 1992. Leishmaniasis in the Caribbean Islands. A review. Ann N Y Acad Sci 653: 154160.[Crossref] [Google Scholar]
  9. Garin YJ, Sulahian A, Meneceur P, Pratlong F, Prina E, Gangneux J, Dedet JP, Derouin F, , 2001. Experimental pathogenicity of a presumed monoxenous trypanosomatid isolated from humans in a murine model. J Eukaryot Microbiol 48: 170176.[Crossref] [Google Scholar]
  10. Courmes E, Escudie A, Fauran P, Monnerville A, , 1966. First native case of human visceral leishmaniasis in Guadeloupe. Bull Soc Pathol Exot 59: 217226. [Google Scholar]
  11. Cnudde F, Raccurt C, Boulard F, Terron-Aboud B, Nicolas M, Juminer B, , 1994. Diffuse cutaneous leishmaniasis with visceral dissemination in an AIDS patient in Guadeloupe, West Indies. AIDS 8: 559560.[Crossref] [Google Scholar]
  12. Kaplan JE, Benson C, Holmes KH, Brooks JT, Pau A, Masur H, , 2009. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. Recomm Rep 58: 1207. [Google Scholar]
  13. Yanamandra U, Jairam A, Shankar S, Negi R, Guleria B, Nair V, , 2011. Visceral leishmaniasis mimicking as second line anti retroviral therapy failure. Intern Med 50: 28552858.[Crossref] [Google Scholar]
  14. Cruz I, Nieto J, Moreno J, Canavate C, Desjeux P, Alvar J, , 2006. Leishmania/HIV co-infections in the second decade. Indian J Med Res 123: 357388. [Google Scholar]
  15. Cota GF, de Sousa MR, Rabello A, , 2011. Predictors of visceral leishmaniasis relapse in HIV-infected patients: a systematic review. PLoS Negl Trop Dis 5: e1153.[Crossref] [Google Scholar]
  16. Dedet JP, Gay F, Chatenay G, , 1989. Isolation of Leishmania species from wild mammals in French Guiana. Trans R Soc Trop Med Hyg 83: 613615.[Crossref] [Google Scholar]

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  • Received : 06 Apr 2014
  • Accepted : 06 Oct 2014
  • Published online : 04 Feb 2015

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