Volume 91, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Splenic infarction is a rare complication of malaria. We report two recent cases of splenic infarction after infection. No systematic review of malaria-induced splenic infarction was available, therefore we conducted a systematic review of the English, French, and Spanish literature in PubMed and KoreaMed for reports of malaria-associated splenic infarction from 1960 to 2012. Of the 40 cases collected on splenic infarction by species, 23 involved , 11 , one , and five a mixed infection of and . Of the 40 cases, 2 (5.0%) involved splenectomy and 5 (12.5%) were accompanied by splenic rupture. The median time from symptom onset to diagnosis was 8.5 days (range, 3–90 days). Improved findings after treatment were observed in 8 (88.9%) of 9 patients with splenic infarction on follow-up by computed tomography or ultrasonography. All patients survived after treatment with the exception of one patient with cerebral malaria. Clinicians should consider the possibility of splenic infarction when malaria-infected patients have left upper quadrant pain.


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  • Received : 28 Mar 2014
  • Accepted : 13 Aug 2014
  • Published online : 03 Dec 2014

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