1921
Volume 91, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Recently there have been calls for the eradication of malaria and the elimination of soil-transmitted helminths (STHs). Malaria and STHs overlap in distribution, and STH infections are associated with increased risk for malaria. Indeed, there is evidence that suggests that STH infection may facilitate malaria transmission. Malaria and STH coinfection may exacerbate anemia, especially in pregnant women, leading to worsened child development and more adverse pregnancy outcomes than these diseases would cause on their own. Ivermectin mass drug administration (MDA) to humans for malaria parasite transmission suppression is being investigated as a potential malaria elimination tool. Adding albendazole to ivermectin MDAs would maximize effects against STHs. A proactive, integrated control platform that targets malaria and STHs would be extremely cost-effective and simultaneously reduce human suffering caused by multiple diseases. This paper outlines the benefits of adding albendazole to ivermectin MDAs for malaria parasite transmission suppression.

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2014-10-01
2017-09-26
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References

  1. Roberts L, Enserink M, , 2007. Malaria—did they really say … eradication? Science 318: 15441545.[Crossref]
  2. Utzinger J, , 2012. A research and development agenda for the control and elimination of human helminthiases. PLoS Negl Trop Dis 6: e1646.[Crossref]
  3. Knopp S, Stothard JR, Rollinson D, Mohammed KA, Khamis IS, Marti H, Utzinger J, , 2013. From morbidity control to transmission control: time to change tactics against helminths on Unguja Island, Zanzibar. Acta Trop 128: 412422.[Crossref]
  4. Molyneux DH, Nantulya VM, , 2004. Linking disease control programmes in rural Africa: a pro-poor strategy to reach Abuja targets and millennium development goals. BMJ 328: 11291132.[Crossref]
  5. Sachs JD, Hotez PJ, , 2006. Fighting tropical diseases. Science 311: 1521.[Crossref]
  6. Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Sachs SE, Sachs JD, , 2006. Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria: a comprehensive pro-poor health policy and strategy for the developing world. PLoS Med 3: 576584.[Crossref]
  7. Hotez PJ, Molyneux DH, , 2008. Tropical anemia: one of Africa's great killers and a rationale for linking malaria and neglected tropical disease control to achieve a common goal. PLoS Negl Trop Dis 2: e270.[Crossref]
  8. Hotez PJ, Mistry N, Rubinstein J, Sachs JD, , 2011. Integrating neglected tropical diseases into AIDS, tuberculosis, and malaria control. N Engl J Med 364: 20862089.[Crossref]
  9. Smits HL, , 2009. Prospects for the control of neglected tropical diseases by mass drug administration. Expert Rev Anti Infect Ther 7: 3756.[Crossref]
  10. Kelly-Hope LA, Molyneux DH, Bockarie MJ, , 2013. Can malaria vector control accelerate the interruption of lymphatic filariasis transmission in Africa; capturing a window of opportunity? Parasit Vectors 6: e39.[Crossref]
  11. Richards FO, Emukah E, Graves PM, Nkwocha O, Nwankwo L, Rakers L, Mosher A, Patterson A, Ozaki M, Nwoke BEB, Ukaga CN, Njoku C, Nwodu K, Obasi A, Miri ES, , 2013. Community-wide distribution of long-lasting insecticidal nets can halt transmission of lymphatic filariasis in southeastern Nigeria. Am J Trop Med Hyg 89: 578587.[Crossref]
  12. Kisinza WN, Kisoka WJ, Mutalemwa PP, Njau J, Tenu F, Nyka T, Kilima SP, Magesa SM, , 2008. Community directed interventions for malaria, tuberculosis and vitamin A in onchocerciasis endemic districts of Tanzania. Tanzan J Health Res 10: 232239.[Crossref]
  13. Remme JHF, Grp CDIS, , 2010. Community-directed interventions for priority health problems in Africa: results of a multicountry study. Bull World Health Organ 88: 509518.[Crossref]
  14. Blackburn BG, Eigege A, Gotau H, Gerlong G, Miri E, Hawley WA, Mathieu E, Richards F, , 2006. Successful integration of insecticide-treated bed net distribution with mass drug administration in Central Nigeria. Am J Trop Med Hyg 75: 650655.
  15. Chaccour CJ, Kobylinski KC, Bassat Q, Bousema T, Drakeley C, Alonso P, Foy BD, , 2013. Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination. Malar J 12: e153.[Crossref]
  16. Sylla M, Kobylinski KC, Gray M, Chapman PL, Sarr MD, Rasgon JL, Foy BD, , 2010. Mass drug administration of ivermectin in south-eastern Senegal reduces the survivorship of wild-caught, blood fed malaria vectors. Malar J 9: e365.[Crossref]
  17. Foy BD, Kobylinski KC, da Silva IM, Rasgon JL, Sylla M, , 2011. Endectocides for malaria control. Trends Parasitol 27: 423428.[Crossref]
  18. Gutman J, Emukah E, Okpala N, Okoro C, Obasi A, Miri ES, Richards FO, , 2010. Effects of annual mass treatment with ivermectin for onchocerciasis on the prevalence of intestinal helminths. Am J Trop Med Hyg 83: 534541.[Crossref]
  19. Olsen A, , 2007. Efficacy and safety of drug combinations in the treatment of schistosomiasis, soil-transmitted helminthiasis, lymphatic filariasis and onchocerciasis. Trans R Soc Trop Med Hyg 101: 747758.[Crossref]
  20. Beach MJ, Streit TG, Addiss DG, Prospere R, Roberts JM, Lammie PJ, , 1999. Assessment of combined ivermectin and albendazole for treatment of intestinal helminth and Wuchereria bancrofti infections in Haitian schoolchildren. Am J Trop Med Hyg 60: 479486.
  21. Ismail MM, Jayakody RL, , 1999. Efficacy of albendazole and its combinations with ivermectin or diethylcarbamazine (DEC) in the treatment of Trichuris trichiura infections in Sri Lanka. Ann Trop Med Parasitol 93: 501504.[Crossref]
  22. Belizario VY, Amarillo ME, de Leon WU, de los Reyes AE, Bugayong MG, Macatangay BJC, , 2003. A comparison of the efficacy of single doses of albendazole, ivermectin, and diethylcarbamazine alone or in combinations against Ascaris and Trichuris spp. Bull World Health Organ 81: 3542.
  23. Knopp S, Mohammed KA, Speich B, Hattendorf J, Khamis IS, Khamis AN, Stothard JR, Rollinson D, Marti H, Utzinger J, , 2010. Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial. Clin Infect Dis 51: 14201428.[Crossref]
  24. Ottesen EA, Ismail MM, Horton J, , 1999. The role of albendazole in programmes to eliminate lymphatic filariasis. Parasitol Today 15: 382386.[Crossref]
  25. Mohammed KA, Deb RM, Stanton MC, Molyneux DH, , 2012. Soil transmitted helminths and scabies in Zanzibar, Tanzania following mass drug administration for lymphatic filariasis—a rapid assessment methodology to assess impact. Parasit Vectors 5: e299.[Crossref]
  26. Gyapong JO, Kumaraswami V, Biswas G, Ottesen EA, , 2005. Treatment strategies underpinning the global programme to eliminate lymphatic filariasis. Expert Opin Pharmacother 6: 179200.[Crossref]
  27. Mwangi TW, Bethony JM, Brooker S, , 2006. Malaria and helminth interactions in humans: an epidemiological viewpoint. Ann Trop Med Parasitol 100: 551570.[Crossref]
  28. Brooker S, Clements ACA, Hotez PJ, Hay SI, Tatem AJ, Bundy DAP, Snow RW, , 2006. The co-distribution of Plasmodium falciparum and hookworm among African schoolchildren. Malar J 5: e99.[Crossref]
  29. Brooker SJ, Pullan RL, Gitonga CW, Ashton RA, Kolaczinski JH, Kabatereine NB, Snow RW, , 2012. Plasmodium-helminth coinfection and its sources of heterogeneity across East Africa. J Infect Dis 205: 841852.[Crossref]
  30. Suputtamongkol Y, Premasathian N, Bhumimuang K, Waywa D, Nilganuwong S, Karuphong E, Anekthananon T, Wanachiwanawin D, Silpasakorn S, , 2011. Efficacy and safety of single and double doses of ivermectin versus 7-day high dose albendazole for chronic strongyloidiasis. PLoS Negl Trop Dis 5: e1044.[Crossref]
  31. Kraivichian K, Nuchprayoon S, Sitichalernchai P, Chaicumpa W, Yentakam S, , 2004. Treatment of cutaneous gnathostomiasis with ivermectin. Am J Trop Med Hyg 71: 623628.
  32. Heukelbach J, Winter B, Wilcke T, Muehlen M, Albrecht S, de Oliveira FAS, Kerr-Pontes LRS, Liesenfeld O, Feldmeier H, , 2004. Selective mass treatment with ivermectin to control intestinal helminthiases and parasitic skin diseases in a severely affected population. Bull World Health Organ 82: 563571.
  33. Okeibunor JC, Amuyunzu-Nyamongo M, Onyeneho NG, Tchounkeu YFL, Manianga C, Kabali AT, Leak S, , 2011. Where would I be without ivermectin? Capturing the benefits of community-directed treatment with ivermectin in Africa. Trop Med Int Health 16: 608621.[Crossref]
  34. Naing C, Whittaker MA, Nyunt-Wai V, Reid SA, Wong SF, Mak JW, Tanner M, , 2013. Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis. Trans R Soc Trop Med Hyg 107: 672683.[Crossref]
  35. Ojurongbe O, Adegbayi AM, Bolaji OS, Akindele AA, Adefioye OA, Adeyeba OA, , 2011. Asymptomatic falciparum malaria and intestinal helminths co-infection among school children in Osogbo, Nigeria. J Res Med Sci 16: 680686.
  36. Yatich NJ, Yi J, Agbenyega T, Turpin A, Rayner JC, Stiles JK, Ellis WO, Funkhouser E, Ehiri JE, Williams JH, Jolly PE, , 2009. Malaria and intestinal helminth co-infection among pregnant women in Ghana: prevalence and risk factors. Am J Trop Med Hyg 80: 896901.
  37. Adegnika AA, Ramharter M, Agnandji ST, Ngoa UA, Issifou S, Yazdanbahksh M, Kremsner PG, , 2010. Epidemiology of parasitic co-infections during pregnancy in Lambarene, Gabon. Trop Med Int Health 15: 12041209.[Crossref]
  38. Degarege A, Legesse M, Medhin G, Animut A, Erko B, , 2012. Malaria and related outcomes in patients with intestinal helminths: a cross-sectional study. BMC Infect Dis 12: 291.[Crossref]
  39. Pullan RL, Kabatereine NB, Bukirwa H, Staedke SG, Brooker S, , 2011. Heterogeneities and consequences of Plasmodium species and hookworm coinfection: a population based study in Uganda. J Infect Dis 203: 406417.[Crossref]
  40. Hillier SD, Booth M, Muhangi L, Nkurunziza P, Khihembo M, Kakande M, Sewankambo M, Kizindo R, Kizza M, Muwanga M, Elliott AM, , 2008. Plasmodium falciparum and helminth coinfection in a semiurban population of pregnant women in Uganda. J Infect Dis 198: 920927.[Crossref]
  41. Fernandez-Nino JA, Idrovo AJ, Cucunuba ZM, Reyes-Harker P, Guerra AP, Moncada LI, Lopez MC, Barrera SM, Cortes LJ, Olivera M, Nicholls RS, , 2012. Paradoxical associations between soil-transmitted helminths and Plasmodium falciparum infection. Trans R Soc Trop Med Hyg 106: 701708.[Crossref]
  42. Righetti AA, Glinz D, Adiossan LG, Koua AYG, Niamke S, Hurrell RF, Wegmuller R, N'Goran EK, Utzinger J, , 2012. Interactions and potential implications of Plasmodium falciparum-hookworm coinfection in different age groups in south-central Cote d'Ivoire. PLoS Negl Trop Dis 6: e1889.[Crossref]
  43. Midzi N, Sangweme D, Zinyowera S, Mapingure MP, Brouwer KC, Munatsi A, Mutapi F, Mudzori J, Kumar N, Woelk G, Mduluza T, , 2008. The burden of polyparasitism among primary schoolchildren in rural and farming areas in Zimbabwe. Trans R Soc Trop Med Hyg 102: 10391045.[Crossref]
  44. Humphries D, Mosites E, Otchere J, Twum WA, Woo L, Jones-Sanpei H, Harrison LM, Bungiro RD, Benham-Pyle B, Bimi L, Edoh D, Bosompem K, Wilson M, Cappello M, , 2011. Epidemiology of hookworm infection in Kintampo North Municipality, Ghana: patterns of malaria coinfection, anemia, and albendazole treatment failure. Am J Trop Med Hyg 84: 792800.[Crossref]
  45. Boel M, Carrara VI, Rijken M, Proux S, Nacher M, Pimanpanarak M, Paw MK, Moo O, Gay H, Bailey W, Singhasivanon P, White NJ, Nosten F, McGready R, , 2010. Complex interactions between soil-transmitted helminths and malaria in pregnant women on the Thai-Burmese border. PLoS Negl Trop Dis 4: e887.[Crossref]
  46. Spiegel A, Tall A, Raphenon G, Trape JF, Druilhe P, , 2003. Increased frequency of malaria attacks in subjects co-infected by intestinal worms and Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg 97: 198199.[Crossref]
  47. Nacher M, Singhasivanon P, Yimsamran S, Manibunyong W, Thanyavanich N, Wuthisen P, Looareesuwan S, , 2002. Intestinal helminth infections are associated with increased incidence of Plasmodium falciparum malaria in Thailand. J Parasitol 88: 5558.[Crossref]
  48. Degarege A, Animut A, Legesse M, Erko B, , 2009. Malaria severity status in patients with soil-transmitted helminth infections. Acta Trop 112: 811.[Crossref]
  49. Nacher M, Singhasivanon P, Gay F, Silachomroon U, Phumratanaprapin W, Looareesuwan S, , 2001. Contemporaneous and successive mixed Plasmodium falciparum and Plasmodium vivax infections are associated with Ascaris lumbricoides: an immunomodulating effect? J Parasitol 87: 912915.[Crossref]
  50. Bousema JT, Drakeley CJ, Mens PF, Arens T, Houben R, Omar SA, Gouagna LC, Schallig H, Sauerwein RW, , 2008. Increased Plasmodium falciparum gametocyte production in mixed infections with P. malariae . Am J Trop Med Hyg 78: 442448.
  51. Gneme A, Guelbeogo WM, Riehle MM, Tiono AB, Diarra A, Kabre GB, Sagnon N, Vernick KD, , 2013. Plasmodium species occurrence, temporal distribution and interaction in a child-aged population in rural Burkina Faso. Malar J 12: e67.[Crossref]
  52. McKenzie FE, Jeffery GM, Collins WE, , 2002. Plasmodium malariae infection boosts Plasmodium falciparum gametocyte production. Am J Trop Med Hyg 67: 411414.
  53. Chaorattanakawee S, Natalang O, Hananantachai H, Nacher M, Brockman A, Nosten F, Looareesuwan S, Patarapotikul J, , 2003. Trichuris trichiura infection is associated with the multiplicity of Plasmodium falciparum infections, in Thailand. Ann Trop Med Parasitol 97: 199202.[Crossref]
  54. Nacher M, Singhasivanon P, Silachamroon U, Treeprasertsuk S, Krudsood S, Gay F, Mazier D, Looareesuwan S, , 2001. Association of helminth infections with increased gametocyte carriage during mild falciparum malaria in Thailand. Am J Trop Med Hyg 65: 644647.
  55. Nacher M, , 2012. Helminth-infected patients with malaria: a low profile transmission hub? Malar J 11: e376.[Crossref]
  56. Kirwan P, Asaolu SO, Molloy SF, Abiona TC, Jackson AL, Holland CV, , 2009. Patterns of soil-transmitted helminth infection and impact of four-monthly albendazole treatments in preschool children from semi-urban communities in Nigeria: a double-blind placebo-controlled randomised trial. BMC Infect Dis 9: e20.[Crossref]
  57. Kirwan P, Jackson AL, Asaolu SO, Molloy SF, Abiona TC, Bruce MC, Ranford-Cartwright L, O'Neill SM, Holland CV, , 2010. Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial. BMC Infect Dis 10: e277.[Crossref]
  58. Brutus L, Watier L, Briand V, Hanitrasoamampionona V, Razanatsoarilala H, Cot M, , 2006. Parasitic co-infections: Does Ascaris lumbricoides protect against Plasmodium falciparum infection? Am J Trop Med Hyg 75: 194198.
  59. Brutus L, Watier L, Hanitrasoarnampionona V, Razanatsoarilala H, Cot M, , 2007. Confirmation of the protective effect of Ascaris lumbricoides on Plasmodium falciparum infection: results of a randomized trial in Madagascar. Am J Trop Med Hyg 77: 10911095.
  60. Le Hesran JY, Akiana J, El Ndiaye HM, Dia M, Senghor P, Konate L, , 2004. Severe malaria attack is associated with high prevalence of Ascaris lumbricoides infection among children in rural Senegal. Trans R Soc Trop Med Hyg 98: 397399.[Crossref]
  61. Nacher M, , 2008. Worms and malaria: blind men feeling the elephant? Parasitology 135: 861868.[Crossref]
  62. Nacher M, , 2011. Interactions between worms and malaria: good worms or bad worms? Malar J 10: e259.[Crossref]
  63. Nacher M, Singhasivanon P, Gay F, Phumratanaprapin W, Silachamroon U, Looareesuwan S, , 2001. Association of helminth infection with decreased reticulocyte counts and hemoglobin concentration in Thai falciparum malaria. Am J Trop Med Hyg 65: 335337.
  64. Midzi N, Mtapuri-Zinyowera S, Mapingure MP, Sangweme D, Chirehwa MT, Brouwer KC, Mudzori J, Hlerema G, Mutapi F, Kumar N, Mduluza T, , 2010. Consequences of polyparasitism on anaemia among primary school children in Zimbabwe. Acta Trop 115: 103111.[Crossref]
  65. Yatich NJ, Jolly PE, Funkhouser E, Agbenyega T, Rayner JC, Ehiri JE, Turpin A, Stiles JK, Ellis WO, Jiang Y, Williams JH, , 2010. The effect of malaria and intestinal helminth coinfection on birth outcomes in Kumasi, Ghana. Am J Trop Med Hyg 82: 2834.[Crossref]
  66. Taylor-Robinson DC, Jones AP, Garner P, , 2007. Deworming drugs for treating soil-transmitted intestinal worms in children: effects on growth and school performance. Cochrane Database Syst Rev 4: CD000371.
  67. Sachs J, Malaney P, , 2002. The economic and social burden of malaria. Nature 415: 680685.[Crossref]
  68. Molyneux DH, Hotez PJ, Fenwick A, , 2005. “Rapid-impact interventions”: how a policy of integrated control for Africa's neglected tropical diseases could benefit the poor. PLoS Med 2: 10641070.[Crossref]
  69. Christian P, Khatry SK, West KP, , 2004. Antenatal anthelmintic treatment, birthweight, and infant survival in rural Nepal. Lancet 364: 981983.[Crossref]
  70. Ndyomugyenyi R, Kabatereine N, Olsen A, Magnussen P, , 2008. Efficacy of ivermectin and albendazole alone and in combination for treatment of soil-transmitted helminths in pregnancy and adverse events: a randomized open label controlled intervention trial in Masindi District, western Uganda. Am J Trop Med Hyg 79: 856863.
  71. Gyapong JO, Chinbuah MA, Gyapong M, , 2003. Inadvertent exposure of pregnant women to ivermectin and albendazole during mass drug administration for lymphatic filariasis. Trop Med Int Health 8: 10931101.[Crossref]
  72. Hibbs RE, Gouaux E, , 2011. Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature 474: 5460.[Crossref]
  73. Kane NS, Hirschberg B, Qian S, Hunt D, Thomas B, Brochu R, Ludmerer SW, Zheng YC, Smith M, Arena JP, Cohen CJ, Schmatz D, Warmke J, Cully DF, , 2000. Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin. Proc Natl Acad Sci USA 97: 1394913954.[Crossref]
  74. Nasveld P, Russell B, Kotecka B, Rieckmann K, , 2003. Lack of in vitro effect of ivermectin on Plasmodium falciparum . Southeast Asian J Trop Med Public Health 34: 552553.
  75. Lariviere M, Beauvais B, Aziz M, Garin YJF, Abeloos J, Derouin F, Bamba M, Bosseboeuf C, Ferlytherizol M, Sarfati C, Basset D, Basset A, Toure Y, Song D, Gaxotte P, , 1989. Study in Ivory Coast (1985–1987) of the efficacy and tolerance of ivermectin (Mectizan) in human onchocerciasis. 1. A double-blind comparative study of 200 patients treated with a single oral doase of 100 mcg/kg, 150 mcg/kg or 200 mcg/kg. Bull Soc Pathol Exot 82: 3547.
  76. Fritz ML, Siegert PY, Walker ED, Bayoh MN, Vulule JR, Miller JR, , 2009. Toxicity of bloodmeals from ivermectin-treated cattle to Anopheles gambiae s.l. Ann Trop Med Parasitol 103: 539547.[Crossref]
  77. Chaccour C, Lines J, Whitty CJM, , 2010. Effect of ivermectin on Anopheles gambiae mosquitoes fed on humans: the potential of oral insecticides in malaria control. J Infect Dis 202: 113116.[Crossref]
  78. Kobylinski KC, Deus KM, Butters MP, Hongyu T, Gray M, da Silva IM, Sylla M, Foy BD, , 2010. The effect of oral anthelmintics on the survivorship and re-feeding frequency of anthropophilic mosquito disease vectors. Acta Trop 116: 119126.[Crossref]
  79. Butters MP, Kobylinski KC, Deus KM, da Silva IM, Gray M, Sylla M, Foy BD, , 2012. Comparative evaluation of systemic drugs for their effects against Anopheles gambiae . Acta Trop 121: 3443.[Crossref]
  80. Kobylinski KC, Foy BD, Richardson JH, , 2012. Ivermectin inhibits the sporogony of Plasmodium falciparum in Anopheles gambiae . Malar J 11: e381.[Crossref]
  81. Kobylinski KC, Sylla M, Chapman PL, Sarr MD, Foy BD, , 2011. Short report: ivermectin mass drug administration to humans disrupts malaria parasite transmission in Senegalese villages. Am J Trop Med Hyg 85: 35.[Crossref]
  82. Alonso PL, Besansky NJ, Burkot TR, Collins FH, Hemingway J, James AA, Lengeler C, Lindsay S, Liu QY, Lobo NF, Mnzava A, Tanner M, Zwiebel L, Consultative Group on Vector Control, , 2011. A research agenda for malaria eradication: vector control. PLoS Med 8: e1000401.[Crossref]
  83. Dieckmann-Schuppert A, Franklin RM, , 1989. Compounds binding to cytoskeletal proteins are active against Plasmodium falciparum in vitro . Cell Biol Int Rep 13: 411418.[Crossref]
  84. Skinner-Adams TS, Davis TME, Manning LS, Johnston WA, , 1997. The efficacy of benzimidazole drugs against Plasmodium falciparum in vitro . Trans R Soc Trop Med Hyg 91: 580584.[Crossref]
  85. Dow GS, Reynoldson JA, Thompson RCA, , 1998. Plasmodium berghei: in vivo efficacy of albendazole in different rodent models. Exp Parasitol 88: 154156.[Crossref]
  86. Dow GS, O'Hara AJ, Newton SC, Reynoldson JA, Thompson RCA, , 2000. Plasmodium berghei: the antimalarial activity of albendazole in rats is mediated via effects on the hematopoietic system. Exp Parasitol 94: 259263.[Crossref]
  87. Bell A, , 1998. Microtubule inhibitors as potential antimalarial agents. Parasitol Today 14: 234240.[Crossref]
  88. Kappes B, Rohrbach P, , 2007. Microtubule inhibitors as a potential treatment for malaria. Future Microbiol 2: 409423.[Crossref]
  89. Chen XY, Zhao LY, Xu HY, Zhong DF, , 2004. Simultaneous determination of albendazole and its major active metabolite in human plasma using a sensitive and specific liquid chromatographic-tandem mass spectrometric method. J Pharm Biomed Anal 35: 829836.[Crossref]
  90. El-Tahtawy A, Glue P, Andrews EN, Mardekian J, Amsden GW, Knirsch CA, , 2008. The effect of azithromycin on ivermectin pharmacokinetics: a population pharmacokinetic model analysis. PLoS Negl Trop Dis 2: e236.[Crossref]
  91. Kobylinski KC, , 2011. Ivermectin mass drug administration to humans for malaria parasite transmission control. Ph.D. dissertation. Fort Collins, CO: Department of Microbiology, Immunology and Pathology, Colorado State University.
  92. Awadzi K, Hero M, Opoku NO, Buttner DW, Coventry PA, Prime MA, Orme ML, Edwards G, , 1994. The chemotherapy of onchocerciasis. 17. A clinical evaluation of albendazole in patients with onchocerciasis—effects of food and pretreatment with ivermectin on drug response and pharmacokinetics. Trop Med Parasitol 45: 203208.
  93. Awadzi K, Addy ET, Opoku NO, Plenge-Bonig A, Buttner DW, , 1995. The chemotherapy of onchocerciasis XX: ivermectin in combination with albendazole. Trop Med Parasitol 46: 213220.
  94. Awadzi K, Edwards G, Duke BOL, Opoku NO, Attah SK, Addy ET, Ardrey AE, Quartey BT, , 2003. The co-administration of ivermectin and albendazole safety, pharmacokinetics and efficacy against Onchocerca volvulus . Ann Trop Med Parasitol 97: 165178.[Crossref]
  95. Peterson LS, Ondiek M, Oludhe DO, Naul BA, Vermund SH, , 2011. Effectiveness of a school-based deworming campaign in rural Kenya. J Trop Pediatr 57: 461463.[Crossref]
  96. Zhang Y, Koukounari A, Kabatereine N, Fleming F, Kazibwe F, Tukahebwa E, Stothard JR, Webster JP, Fenwick A, , 2007. Parasitological impact of 2-year preventive chemotherapy on schistosomiasis and soil-transmitted helminthiasis in Uganda. BMC Med 5: e27.[Crossref]
  97. Knopp S, Steinmann P, Keiser J, Utzinger J, , 2012. Nematode infections soil-transmitted helminths and Trichinella . Infect Dis Clin North Am 26: 341358.[Crossref]
  98. Barry MA, Simon GG, Mistry N, Hotez PJ, , 2013. Global trends in neglected tropical disease control and elimination: impact on child health. Arch Dis Child 98: 635641.[Crossref]
  99. Humphries D, Nguyen S, Boakye D, Wilson M, Cappello M, , 2012. The promise and pitfalls of mass drug administration to control intestinal helminth infections. Curr Opin Infect Dis 25: 584589.[Crossref]
  100. Prichard RK, Basanez MG, Boatin BA, McCarthy JS, Garcia HH, Yang GJ, Sripa B, Lustigman S, , 2012. A research agenda for helminth diseases of humans: intervention for control and elimination. PLoS Negl Trop Dis 6: e1549.[Crossref]
  101. Hall A, Hewitt G, Tuffrey V, de Silva N, , 2008. A review and meta-analysis of the impact of intestinal worms on child growth and nutrition. Matern Child Nutr 4 (Suppl 1): 118236.[Crossref]
  102. Vercruysse J, Behnke JM, Albonico M, Ame SM, Angebault C, Bethony JM, Engels D, Guillard B, Hoa NTV, Kang G, Kattula D, Kotze AC, McCarthy JS, Mekonnen Z, Montresor A, Periago MV, Sumo L, Tchuente LAT, Thach DTC, Zeynudin A, Levecke B, , 2011. Assessment of the anthelmintic efficacy of albendazole in school children in seven countries where soil-transmitted helminths are endemic. PLoS Negl Trop Dis 5: e948.[Crossref]
  103. Keiser J, Utzinger J, , 2008. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 299: 19371948.[Crossref]
  104. Geary TG, Woo K, McCarthy JS, Mackenzie CD, Horton J, Prichard RK, de Silva NR, Olliaro PL, Lazdins-Helds JK, Engels DA, Bundy DA, , 2010. Unresolved issues in anthelmintic pharmacology for helminthiases of humans. Int J Parasitol 40: 113.[Crossref]
  105. Campbell SJ, Savage GB, Gray DJ, Atkinson JA, Soares Magalhaes RJ, Nery SV, McCarthy JS, Velleman Y, Wicken JH, Traub RJ, Williams GM, Andrews RM, Clements AC, , 2014. Water, Sanitation and Hygiene (WASH): a critical componenet for sustainable soil-transmitted helminth and schistosomiasis control. PLoS Negl Trop Dis 8: e2651.[Crossref]
  106. Cully DF, Vassilatis DK, Liu KK, Paress PS, Vanderploeg LHT, Schaeffer JM, Arena JP, , 1994. Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans . Nature 371: 707711.[Crossref]
  107. Borgers M, Denollin S, Debrabander M, Thienpont D, , 1975. Influence of anthelmintic mebendazole on microtubules and intracellular organelle movement in nematode intestinal cells. Am J Vet Res 36: 11531166.
  108. James CE, Davey MW, , 2009. Increased expression of ABC transport proteins is associated with ivermectin resistance in the model nematode Caenorhabditis elegans . Int J Parasitol 39: 213220.[Crossref]
  109. Mottier MD, Prichard RK, , 2008. Genetic analysis of a relationship between macrocyclic lactone and benzimidazole anthelmintic selection on Haemonchus contortus . Pharmacogenet Genomics 18: 129140.[Crossref]
  110. Diawara A, Drake LJ, Suswillo RR, Kihara J, Bundy DAP, Scott ME, Halpenny C, Stothard JR, Prichard RK, , 2009. Assays to detect beta-tubulin codon 200 polymorphism in Trichuris trichiura and Ascaris lumbricoides . PLoS Negl Trop Dis 3: e397.[Crossref]
  111. Goldman AS, Guisinger VH, Aikins M, Amarillo MLE, Belizario VY, Garshong B, Gyapong J, Kabali C, Kamal HA, Kanjilal S, Kyelem D, Lizardo J, Malecela M, Mubyazi G, Nitiema PA, Ramzy RMR, Streit TG, Wallace A, Brady MA, Rheingans R, Ottesen EA, Haddix AC, , 2007. National mass drug administration costs for lymphatic filariasis elimination. PLoS Negl Trop Dis 1: e67.[Crossref]
  112. Burnham G, Mebrahtu T, , 2004. Review: The delivery of ivermectin (Mectizan (R)). Trop Med Int Health 9: A26A44.[Crossref]
  113. Amazigo UV, Brieger WR, Katabarwa M, Akogun O, Ntep M, Boatin B, N'Doyo J, Noma M, Seketeli A, , 2002. The challenges of community-directed treatment with ivermectin (CDTI) within the African Programme for Onchocerciasis Control (APOC). Ann Trop Med Parasitol 96: 4158.[Crossref]
  114. Gustavsen KM, Bradley MH, Wright AL, , 2009. GlaxoSmithKline and Merck: private-sector collaboration for the elimination of lymphatic filariasis. Ann Trop Med Parasitol 103: S11S15.[Crossref]
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  • Received : 27 Mar 2014
  • Accepted : 04 Jun 2014

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