1921
Volume 92, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We conducted a follow-up survey for 55 Japanese encephalitis (JE) cases 1–2 years after hospital discharge in Gansu province, China. Community-, education-, and gender-matched healthy individuals without history of neurologic disease were selected as the comparison group. All subjects received neurological examination, intelligence quotient (IQ) measurement, adaptive behavior measurement, and Wechsler memory scale (WMS) assessment. We found 43.6% JE cases had at least one nervous system sequelae compared with 3.6% healthy individuals. Among JE cases, 22.4% had subnormal IQ, 18.4% subnormal verbal IQ (VIQ), 20.4% subnormal performance IQ (PIQ), and 78.4% had subnormal memory quotient (MQ). Among healthy individuals, 2.0% had subnormal IQ, VIQ, or PIQ and 8.1% had subnormal MQ. Among adult JE cases, 47.8% and 39.1% had adaptive behavior impairments and intellectual disability, respectively, compared with 18.8% and 9.7% among young cases, respectively. The results showed both adult and young surviving JE cases had significant neurological sequelae and mental disability 1–2 years after discharged.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.14-0148
2015-06-03
2018-12-17
Loading full text...

Full text loading...

/deliver/fulltext/14761645/92/6/1125.html?itemId=/content/journals/10.4269/ajtmh.14-0148&mimeType=html&fmt=ahah

References

  1. WHO, 2006. Position paper on Japanese encephalitis vaccines. Wkly Epidemiol Rec 81: 331339. [Google Scholar]
  2. Fischer M, Hills S, Staples E, Johnson B, Yaich M, Scheld WM, Hammer SM, Hughes JM, , 2008. Japanese encephalitis prevention and control: advances, challenges, and new initiatives. , eds. Emerging Infections 8. Washington, DC: ASM Press, 93124.[Crossref] [Google Scholar]
  3. Campbell GL, Hills SL, Fischer M, Jacobson JA, Hoke CH, Hombach JM, Marfin AA, Solomon T, Tsai TF, Tsu VD, Ginsburg AS, , 2011. Estimated global incidence of Japanese encephalitis: a systematic review. Bull World Health Organ 89: 766774E.[Crossref] [Google Scholar]
  4. Wang H, Li Y, Liang X, Liang G, , 2009. Japanese encephalitis in mainland China. Jpn J Infect Dis 62: 331336. [Google Scholar]
  5. Wang X, Li Y, Liang X, Gao L, Zhang X, Hui L, , 2010. Distribution features of Japanese encephalitis B in Gansu Province [In Chinese]. China Trop Med 10: 12041204. [Google Scholar]
  6. Yin Z, Liang X, Li Y, Wang H, Zhai R, Liang G, Shui T, Ze W, Li X, Lv X, Yang H, Guang M, Chen S, , 2007. Investigation and analysis on the Japanese B encephalitis epidemic in Yuncheng Prefecture, Shanxi Province, 2006 [In Chinese]. Chin J Vaccines and Immuniz 13: 270273. [Google Scholar]
  7. Ding Z, Xu Z, , 2001. Retrospective analysis of Japanese encephalitis (JE) incidence in Shanghai [In Chinese]. Chin J Vaccines and Immuniz 7: 146148. [Google Scholar]
  8. Yin Z, Wang H, Yang J, Luo H, Li Y, Hadler SC, Sandhu HS, Fischer M, Jiang Y, Zhang Z, Liu G, Li L, Johnson BW, Liang X, Acute Meningitis and Encephalitis Syndrome (AMES) Study Group, , 2010. Japanese encephalitis disease burden and clinical features in 4 cities of China, a laboratory based acute encephalitis surveillance. Am J Trop Med Hyg 84: 766773.[Crossref] [Google Scholar]
  9. Halstead SB, Jacobson J, Plotkin SA, Orenstein WA, Offit PA, , 2008. Japanese encephalitis vaccines. , eds. Vaccines. Philadelphia, PA: Elsevier Health Sciences. [Google Scholar]
  10. Oya A, , 1989. Epidemiology of Japanese encephalitis, Rinsho to Biseibutsu. Clin Diagn Microbiol 16: 59. [Google Scholar]
  11. Kumar R, Mathur A, Singh KB, Sitholey P, Prasad M, Shukla R, Agarwal SP, Arockiasamy J, , 1993. Clinical sequelae of Japanese encephalitis in children. Indian J Med Res 97: 913. [Google Scholar]
  12. Huy BV, Tu HC, Luan TV, Lindqvist R, , 1994. Early mental and neurological sequelae after Japanese B encephalitis. Southeast Asian J Trop Med Public Health 25: 549553. [Google Scholar]
  13. Kamala CS, Rao MV, George S, Prasanna NY, , 1989. Japanese encephalitis in children in Bellary, Karnataka. Indian Pediatr 26: 445452. [Google Scholar]
  14. Baruah HC, Biswas D, Patgiri D, Mahanta J, , 2002. Clinical outcome and neurological sequelae in serologically confirmed cases of Japanese encephalitis patients in Assam, India. Indian Pediatr 39: 11431148. [Google Scholar]
  15. Misra UK, Kalita J, Srivastava M, , 1998. Prognosis of Japanese encephalitis: a multivariate analysis. J Neurol Sci 161: 143147.[Crossref] [Google Scholar]
  16. Potula R, Badrinath S, Srinivasan S, , 2003. Japanese encephalitis in and around Pondicherry, south India: a clinical appraisal and prognostic indicators for the outcome. J Trop Pediatr 49: 4853.[Crossref] [Google Scholar]
  17. Ding D, Hong Z, Zhao SJ, Clemens JD, Zhou B, Wang B, Huang MS, Zeng J, Guo QH, Liu W, Tao FB, Xu ZY, , 2007. Long-term disability from acute childhood Japanese encephalitis in Shanghai, China. Am J Trop Med Hyg 77: 528533. [Google Scholar]
  18. Feng L, , 1987. Long-term follow-up of 50 cases of Japanese encephalitis [In Chinese]. J Clin Pediatr 5: 131133. [Google Scholar]
  19. Wang B, Ding D, Hong Z, Zhou F, Huang MS, Zeng J, Guo QH, , 2002. Memory impairment and related factors analysis with Japanese Encephalitis patients [In Chinese]. J of Brain and Nervous Diseases 10: 357358. [Google Scholar]
  20. Wu YC, Huang YS, Chien LJ, Lin TL, Yueh YY, Tseng WL, Chang KJ, Wang GR, , 1999. The epidemiology of Japanese encephalitis on Taiwan during 1966–1997. Am J Trop Med Hyg 61: 7884. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.14-0148
Loading
/content/journals/10.4269/ajtmh.14-0148
Loading

Data & Media loading...

  • Received : 11 Mar 2014
  • Accepted : 04 Mar 2015

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error