1921
Volume 91, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Understanding biodiversity and transmission is significant for tuberculosis control. This short report aimed to determine the genetic diversity of isolates from an outpatient clinic in Panama City. A total of 62 isolates were genotyped by 12 loci mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) and Spoligotyping. Forty-five (72.6%) of the isolates showed unique MIRU-VNTR genotypes, and 13 (21%) of the isolates were grouped into four clusters. Four isolates showed polyclonal MIRU-VNTR genotypes. The MIRU-VNTR Hunter-Gaston discriminatory index reached 0.988. The Spoligotyping analysis revealed 16 families, including Latin American-Mediterranean, Harlem, and Beijing. These findings suggest a wide genetic diversity of isolates at one outpatient clinic. A detailed molecular epidemiology survey is now warranted, especially following second massive immigration for local Panama Canal expansion activities.

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2014-08-06
2017-11-19
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  • Received : 05 Mar 2014
  • Accepted : 30 Mar 2014

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