1921
Volume 91, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Multiple infections within the same household are common. Household contacts of patients with cholera were observed with daily clinical assessments and collection of rectal swab cultures for nine days after presentation of the index case. During the follow-up period, 71 (24%) of 294 household contacts developed a positive rectal swab, signifying bacterial shedding. The average length of bacterial shedding was 2.0 days (95% confidence interval 1.7–2.4). However, 16 (5%) of 294 contacts shed for ≥ 4 days. In a multivariate analysis, malnutrition was predictive of long-term shedding (odds ratio = 1.4, 95% confidence interval = 1.3–13, = 0.02). High rates of infection and bacterial shedding among household contacts of cholera patients represent an opportunity for intervention to reduce transmission.

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2014-10-01
2017-11-20
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  • Received : 11 Feb 2014
  • Accepted : 26 Jun 2014

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