1921
Volume 90, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The p53 protein is a key cell-signaling mediator integrating host responses to various types of stress. A common polymorphism of the encoding gene (codon 72, Pro > Arg, rs1042522) is associated with susceptibility to virus-related and other cancers. The p53 has also been shown to be central for successful liver stage infection. We examined whether the polymorphism is associated with infection in Ghanaian primiparae and Rwandan children. The allele frequency of codon 72 Arg was 0.30 among 314 Ghanaian primiparae and 0.31 among 545 Rwandan children, respectively, and it was not associated with infection prevalence or parasite density. This does not exclude p53 to be of pathophysiological relevance in malaria but argues against a major respective role of the codon 72 polymorphism.

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2014-06-04
2017-09-23
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  • Received : 21 Jan 2014
  • Accepted : 06 Mar 2014

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