1921
Volume 91, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Cutaneous leishmaniasis (CL) is endemic in the Bikaner region situated in the Thar Desert of Rajasthan, India. This study describes clinicoepidemiological data of pediatric CL in pre-school children (0–5 years of age) from this region during 2001–2012. In total, 151 patients with 217 lesions were reported during the study period. The mean age of the study group was 3.29 ± 1.43 years (0.25–5 years), with many (41.7%) cases being in the age group of 2–4 years. Face was the most common site involved, and morphologically, the lesions were either plaque type or papulonodular. Smear for parasitologic examination was positive in 84 (70%) of 120 cases, and histopathologic examination confirmed CL in 10 (55.55%) of 18 cases. Parasite species identification conducted for 13 randomly selected patients by polymerase chain reaction identified as the causative species. Intralesional sodium stibogluconate was the most commonly used treatment and found to be well-tolerated. Other therapies that were effective included oral rifampicin, oral dapsone, radiofrequency heat therapy (RFHT), and combinations of the three therapies.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.13-0737
2014-11-05
2017-11-18
Loading full text...

Full text loading...

/deliver/fulltext/14761645/91/5/901.html?itemId=/content/journals/10.4269/ajtmh.13-0737&mimeType=html&fmt=ahah

References

  1. Reithinger R, Dujardin JC, Louzir H, Pirmez C, Alexander B, Brooker S, , 2007. Cutaneous leishmaniasis. Lancet Infect Dis 7: 581596.[Crossref]
  2. WHO, 2010. Control of the leishmaniases. Proceedings of the Meeting of the WHO Expert Committee on the Control of Leishmaniases. WHO Technical Report Series 949, March 22–26, 2010, Geneva, Switzerland.
  3. Srivastava D, Vyas MCR, Joshi CK, , 1987. Clinico epidemiological study of cutaneous leishmaniasis in Bikaner (Rajasthan). J Commun Dis 19: 326331.
  4. Kumar R, Bumb RA, Ansari NA, Mehta RD, Salotra P, , 2007. Cutaneous leishmaniasis caused by Leishmania tropica in Bikaner, India: parasite identification and characterization using molecular and immunologic tools. Am J Trop Med Hyg 76: 896901.
  5. Kafetzis DA, , 2003. An overview of paediatric leishmaniasis. J Postgrad Med 49: 3138.[Crossref]
  6. Bari AU, , 2008. Childhood cutaneous leishmaniasis. J Clin Diagn Res 2: 973978.
  7. Zaraa I, Ishak F, Kort R, El Euch D, Mokni M, Chaker E, Ben Osman A, , 2010. Childhood and adult cutaneous leishmaniasis in Tunisia. Int J Dermatol 49: 790793.[Crossref]
  8. Shoaib S, Tauheed S, Hafeez A, , 2007. Cutaneous leishmaniasis: an emerging childhood infection. J Ayub Med Coll Abbottabad 19: 4041.
  9. Qasmi S, Elguelbazouri N, Belgnaoui FZ, Marcil T, Bouhllab J, Senouci K, Aitourhoui M, Hassam B, , 2008. Childhood cutaneous leishmaniasis: experience of a Moroccan unit of dermatology. Dermatol Online J 14: 18.
  10. Talari SA, Talaei R, Shajari G, Vakili Z, Taghaviardakani A, , 2006. Childhood cutaneous leishmaniasis: report of 117 cases from Iran. Korean J Parasitol 44: 355360.[Crossref]
  11. Kharfi M, Benmously R, El Fekih N, Daoud M, Fitouri Z, Mokhtar I, Ben Becher S, Kamoun MR, , 2004. Childhood leishmaniasis: report of 106 cases. Dermatol Online J 10: 6.
  12. Fenniche S, Souissi A, Benmously R, Ben Jannet S, Marrak H, Mokhtar I, , 2006. Childhood cutaneous leishmaniasis in Tunisia: retrospective study of 60 cases. Med Trop (Mars) 66: 456460.
  13. Gurel MS, Ulukanligil M, Ozbilge H, , 2002. Cutaneous leishmaniasis in Sanliurfa: epidemiologic and clinical features of the last four years (1997–2000). Int J Dermatol 41: 3237.[Crossref]
  14. Rodrigues EH, Felinto de Brito ME, Mendonça MG, Werkhäuser RP, Coutinho EM, Souza WV, Militão de Albuquerque M de F, Jardim ML, Abath FG, , 2002. Evaluation of PCR for diagnosis of American cutaneous leishmaniasis in an area of endemicity in northeastern Brazil. J Clin Microbiol 40: 35723576.[Crossref]
  15. Al-Hucheimi SN, Sultan BA, Al-Dhalimi MA, , 2009. A comparative study of the diagnosis of Old World cutaneous leishmaniasis in Iraq by polymerase chain reaction and microbiologic and histopathologic methods. Int J Dermatol 48: 404408.[Crossref]
  16. Vega-López F, , 2003. Diagnosis of cutaneous leishmaniasis. Curr Opin Infect Dis 16: 97101.[Crossref]
  17. Marco JD, Barroso PA, Mimori T, Locatelli FM, Tomatani A, Mora MC, Cajal SP, Nasser JR, Parada LA, Taniguchi T, Korenaga M, Basombrío MA, Hashiguchi Y, , 2012. Polymorphism-specific PCR enhances the diagnostic performance of American tegumentary leishmaniasis and allows the rapid identification of Leishmania species from Argentina. BMC Infect Dis 12: 191.[Crossref]
  18. Kochar DK, Aseri S, Sharma BV, Bumb RA, Mehta RD, Purohit SK, , 2000. The role of rifampicin in the management of cutaneous leishmaniasis. QJM 93: 733737.[Crossref]
  19. Bumb RA, Mehta RD, , 2002. Oral rifampicin in cases of cutaneous leishmaniasis with multiple lesions (a pilot study). Indian J Dermatol Venereol Leprol 68: 272.
  20. Salim MM, Kandil E, , 1972. Rifampicin in the treatment of cutaneous leishmaniasis. J Kuwait Med Assoc 6: 159166.
  21. Sadeghian G, Nilfroushzadeh MA, Iraji F, , 2007. Efficacy of local heat therapy by radiofrequency in the treatment of cutaneous leishmaniasis, compared with intralesional injection of meglumineantimoniate. Clin Exp Dermatol 32: 371374.[Crossref]
  22. Bumb RA, Prasad N, Khandelwal K, Aara N, Mehta RD, Ghiya BC, Salotra P, Wei L, Peters S, Satoskar AR, , 2013. Long-term efficacy of single-dose radiofrequency-induced heat therapy vs. intralesionalantimonials for cutaneous leishmaniasis in India. Br J Dermatol 168: 11141119.[Crossref]
  23. Dogra J, , 1986. Dapsone in the treatment of cutaneous leishmaniasis. Int J Dermatol 25: 398401.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.13-0737
Loading
/content/journals/10.4269/ajtmh.13-0737
Loading

Data & Media loading...

  • Received : 14 Dec 2013
  • Accepted : 31 May 2014

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error