1921
Volume 90, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Although reports suggest that increases hepatitis C virus (HCV) morbidity and chronicity, its impact on HCV spontaneous resolution is not clear. HCV genotype, viral load, abdominal ultrasonographic findings, and HCV-specific cell-mediated immunity (CMI) were examined among 141 healthcare workers infected with HCV (68 workers with and 73 workers without ). HCV genotype 4 was dominate, and viral loads were 2.62 ± 0.69 × 10 and 4.24 ± 1.4 × 10 IU/mL among patients with and without coinfection, respectively ( = 0.309); 23.5% with and 32.9% without coinfection had spontaneously resolved HCV infection ( = 0.297). Interferon-γ spot-forming cells/10 peripheral blood mononuclear cells among responding viremic patients with and without coinfection were 716 ± 194 and 587 ± 162, whereas among aviremic patients, it was 794 ± 272 and 365 ± 36 ( 0.05), respectively. In conclusion, there was no statistical difference in HCV spontaneous resolution, viral load, liver pathology, or CMI in patients with or without coinfection, suggesting that it did not impact the outcome of HCV infection.

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2014-05-07
2017-11-21
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References

  1. Lauer GM, Walker BD, , 2001. Hepatitis C virus infection. N Engl J Med 345: 4152.[Crossref]
  2. Liang TJ, Rehermann B, Seeff LB, Hoofnagle JH, , 2000. Pathogenesis, natural history, treatment and prevention of hepatitis C. Ann Intern Med 132: 296.[Crossref]
  3. Seeff LB, , 1998. The natural history of hepatitis C-A quandary. Hepatology 28: 17101712.[Crossref]
  4. Guerra J, Garenne M, Mohamed MK, Fontanet A, , 2012. HCV burden of infection in Egypt: results from a nationwide survey. J Viral Hepat 19: 560567.[Crossref]
  5. Ryder SD, Irving WL, Jones DA, Neal KR, Underwood JC, , 2004. Progression of hepatic fibrosis in patients with hepatitis C: a prospective repeat liver biopsy study. Gut 53: 451455.[Crossref]
  6. Missiha SB, Ostrowski M, Heathcote EJ, , 2008. Disease progression in chronic hepatitis C: modifiable and nonmodifiable factors. Gastroenterology 134: 16991714.[Crossref]
  7. Thomas DL, Astemborski J, Rai RM, Anania FA, Schaeffer M, Galai N, Nolt K, Nelson KE, Strathdee SA, Johnson L, Laeyendecker O, Boitnott J, Wilson LE, Vlahov D, , 2000. The natural history of hepatitis C virus infection: host, viral and environmental factors. JAMA 284: 450456.[Crossref]
  8. Blanton RE, Salam EA, Kariuki HC, Magak P, Silva LK, Muchiri EM, Thiongo F, Abdel-Meghid IE, Butterworth AE, Reis MG, Ouma JH, , 2002. Population-based differences in Schistosoma mansoni- and hepatitis C-induced disease. J Infect Dis 185: 16441649.[Crossref]
  9. Angelico M, Renganathan E, Gandin C, Fathy M, Profili MC, Refai W, De Santis A, Nagi A, Amin G, Capocaccia L, Callea F, Rapicetta M, Badr G, Rocchi G, , 1997. Chronic liver disease in the Alexandria governorate, Egypt: contribution of schistosomiasis and hepatitis virus infections. J Hepatol 26: 236243.[Crossref]
  10. El-Awady MK, Youssef SS, Omran MH, Tabll AA, El Garf WT, Salem AM, , 2006. Soluble egg antigen of Schistosoma haematobium induces HCV replication in PBMC from patients with chronic HCV infection. BMC Infect Dis 6: 91.[Crossref]
  11. Kamal S, Madwar M, Bianchi L, Tawil AE, Fawzy R, Peters T, Rasenack JW, , 2000. Clinical, virological and histopathological features: long-term follow-up in patients with chronic hepatitis C co-infected with S. mansoni . Liver 20: 281289.[Crossref]
  12. Iida F, Iida R, Kamijo H, Takaso K, Miyazaki Y, Funabashi W, Tsuchiya K, Matsumoto Y, , 1999. Chronic Japanese schistosomiasis and hepatocellular carcinoma: ten years of follow-up in Yamanashi Prefecture, Japan. Bull World Health Organ 77: 573581.
  13. Hassan MM, Zaghloul AS, El-Serag HB, Soliman O, Patt YZ, Chappell CL, Beasley RP, Hwang LY, , 2001. The role of hepatitis C in hepatocellular carcinoma: a case control study among Egyptian patients. J Clin Gastroenterol 33: 123126.[Crossref]
  14. Barria MI, Vera-Otarola J, Leon U, Vollrath V, Marsac D, Riquelme A, Lopez-Lastra M, Soza A, , 2008. Influence of extrahepatic viral infection on the natural history of hepatitis C. Ann Hepatol 7: 136143.
  15. Derbala M, Amer A, , 2009. Hepatocellular carcinoma in Hepatitis C genotype 4 after viral clearance and in absence of cirrhosis: two case reports. Cases J 2: 7927.[Crossref]
  16. el-Shazly Y, Abdel-Salam AF, Abdel-Ghaffar A, Mohran Z, Saleh SM, , 1994. Schistosomiasis as an important determining factor for the response of Egyptian patients with chronic hepatitis C to therapy with recombinant human alpha-2 interferon. Trans R Soc Trop Med Hyg 88: 229231.[Crossref]
  17. Kamal SM, Madwar MA, Peters T, Fawzy R, Rasenack J, , 2000. Interferon therapy in patients with chronic hepatitis C and schistosomiasis. J Hepatol 32: 172174.[Crossref]
  18. Kamal SM, El Tawil AA, Nakano T, He Q, Rasenack J, Hakam SA, Saleh WA, Ismail A, Aziz AA, Madwar MA, , 2005. Peginterferon {alpha}-2b and ribavirin therapy in chronic hepatitis C genotype 4: impact of treatment duration and viral kinetics on sustained virological response. Gut 54: 858866.[Crossref]
  19. Pearce EJ, MacDonald AS, , 2002. The immunobiology of schistosomiasis. Nat Rev Immunol 2: 499511.[Crossref]
  20. Cerny A, Chisari FV, , 1999. Pathogenesis of chronic hepatitis C: immunological features of hepatic injury and viral persistence. Hepatology 30: 595601.[Crossref]
  21. Kamal SM, Rasenack JW, Bianchi L, Al Tawil A, El Sayed Khalifa K, Peter T, Mansour H, Ezzat W, Koziel M, , 2001. Acute hepatitis C without and with schistosomiasis: correlation with hepatitis C-specific CD4(+) T-cell and cytokine response. Gastroenterology 121: 646656.[Crossref]
  22. Gerlach JT, Diepolder HM, Jung MC, Gruener NH, Schraut WW, Zachoval R, Hoffmann R, Schirren CA, Santantonio T, Pape GR, , 1999. Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C. Gastroenterology 117: 933941.[Crossref]
  23. Rehermann B, , 1999. Cellular immune response to the hepatitis C virus. J Viral Hepat 6 (Suppl 1): 3135.[Crossref]
  24. Lechner F, Wong DK, Dunbar PR, Chapman R, Chung RT, Dohrenwend P, Robbins G, Phillips R, Klenerman P, Walker BD, , 2000. Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 191: 14991512.[Crossref]
  25. Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV, , 2001. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 194: 13951406.[Crossref]
  26. Kamal SM, Bianchi L, Al Tawil A, Koziel M, El Sayed Khalifa K, Peter T, Rasenack JW, , 2001. Specific cellular immune response and cytokine patterns in patients coinfected with hepatitis C virus and Schistosoma mansoni . J Infect Dis 184: 972982.[Crossref]
  27. Ezenwa VO, Jolles AE, , 2011. From host immunity to pathogen invasion: the effects of helminth coinfection on the dynamics of microparasites. Integr Comp Biol 51: 540551.[Crossref]
  28. Abdelwahab S, Rewisha E, Hashem M, Sobhy M, Galal I, Allam WR, Mikhail N, Galal G, El-Tabbakh M, El-Kamary SS, Waked I, Strickland GT, , 2012. Risk factors for hepatitis C virus infection among Egyptian healthcare workers in a national liver diseases referral centre. Trans R Soc Trop Med Hyg 106: 98103.[Crossref]
  29. Abdelwahab SF, Hashem M, Galal I, Sobhy M, Abdel-Ghaffar TS, Galal G, Mikhail N, El-Kamary SS, Waked I, Strickland GT, , 2013. Incidence of hepatitis C virus infection among Egyptian healthcare workers at high risk of infection. J Clin Virol 57: 2428.[Crossref]
  30. McOmish F, Yap PL, Dow BC, Follett EA, Seed C, Keller AJ, Cobain TJ, Krusius T, Kolho E, Naukkarinen R, Lin C, Lai C, Leong S, Medgyesi GA, Hejjas M, Kiyokawa H, Fukada K, Cuypers T, Saeed AA, Al-Rasheed AM, Lin M, Simmonds P, , 1994. Geographical distribution of hepatitis C virus genotypes in blood donors: an international collaborative survey. J Clin Microbiol 32: 884892.
  31. Ohno O, Mizokami M, Wu RR, Saleh MG, Ohba K, Orito E, Mukaide M, Williams R, Lau JY, , 1997. New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a. J Clin Microbiol 35: 201207.
  32. Abdelwahab SF, Zakaria Z, Sobhy M, Rewisha E, Mahmoud MA, Amer MA, Del Sorbo M, Capone S, Nicosia A, Folgori A, Hashem M, El-Kamary SS, , 2012. Hepatitis C virus-multispecific T-cell responses without viremia or seroconversion among Egyptian health care workers at high risk of infection. Clin Vaccine Immunol 19: 780786.[Crossref]
  33. Al-Sherbiny M, Osman A, Mohamed N, Shata MT, Abdel-Aziz F, Abdel-Hamid M, Abdelwahab SF, Mikhail N, Stoszek S, Ruggeri L, Folgori A, Nicosia A, Prince AM, Strickland GT, , 2005. Exposure to hepatitis C virus induces cellular immune responses without detectable viremia or seroconversion. Am J Trop Med Hyg 73: 4449.
  34. Abdel-Aziz F, Habib M, Mohamed MK, Abdel-Hamid M, Gamil F, Madkour S, Mikhail NN, Thomas D, Fix AD, Strickland GT, Anwar W, Sallam I, , 2000. Hepatitis C virus (HCV) infection in a community in the Nile Delta: population description and HCV prevalence. Hepatology 32: 111115.[Crossref]
  35. Strickland GT, Elhefni H, Salman T, Waked I, Abdel-Hamid M, Mikhail NN, Esmat G, Fix A, , 2002. Role of hepatitis C infection in chronic liver disease in Egypt. Am J Trop Med Hyg 67: 436442.
  36. Kamal SM, Madwar MA, Peters T, Fawzy R, Rasenack J, , 2000. Interferon therapy in patients with chronic hepatitis C and schistosomiasis. J Hepatol 32: 172174.[Crossref]
  37. Pearce EJ, Caspar P, Grzych JM, Lewis FA, Sher A, , 1991. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni . J Exp Med 173: 159166.[Crossref]
  38. Cheever AW, Jankovic D, Yap GS, Kullberg MC, Sher A, Wynn TA, , 1998. Role of cytokines in the formation and downregulation of hepatic circumoval granulomas and hepatic fibrosis in Schistosoma mansoni-infected mice. Mem Inst Oswaldo Cruz 93 (Suppl 1): 2532.[Crossref]
  39. King CL, Medhat A, Malhotra I, Nafeh M, Helmy A, Khaudary J, Ibrahim S, El-Sherbiny M, Zaky S, Stupi RJ, Brustoski K, Shehata M, Shata MT, , 1996. Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity. J Immunol 156: 47154721.
  40. Scott JT, Turner CM, Mutapi F, Woolhouse ME, Ndhlovu PD, Hagan P, , 2001. Cytokine responses to mitogen and Schistosoma haematobium antigens are different in children with distinct infection histories. Parasite Immunol 23: 519526.[Crossref]
  41. Derbala MF, Amer AM, Almohanadi M, John A, Amin A, Sharma M, Alkaabi SR, Al Dweik NZ, Pasic F, Yaqoob R, Butt MT, Shebl FM, , 2011. Hepatitis C virus genotype 4 with normal transaminases: histological changes, schistosomiasis and response to treatment. J Viral Hepat 18: e258e262.[Crossref]
  42. Farid A, Al-Sherbiny M, Osman A, Mohamed N, Saad A, Shata MT, Lee DH, Prince AM, Strickland GT, , 2005. Schistosoma infection inhibits cellular immune responses to core HCV peptides. Parasite Immunol 27: 189196.[Crossref]
  43. Elrefaei M, El-sheikh N, Kamal K, Cao H, , 2004. Analysis of T cell responses against hepatitis C virus genotype 4 in Egypt. J Hepatol 40: 313318.[Crossref]
  44. Kamal SM, Graham CS, He Q, Bianchi L, Tawil AA, Rasenack JW, Khalifa KA, Massoud MM, Koziel MJ, , 2004. Kinetics of intrahepatic hepatitis C virus (HCV)-specific CD4+ T cell responses in HCV and Schistosoma mansoni coinfection: relation to progression of liver fibrosis. J Infect Dis 189: 11401150.[Crossref]
  45. Kamal SM, Turner B, He Q, Rasenack J, Bianchi L, Al Tawil A, Nooman A, Massoud M, Koziel MJ, Afdhal NH, , 2006. Progression of fibrosis in hepatitis C with and without schistosomiasis: correlation with serum markers of fibrosis. Hepatology 43: 771779.[Crossref]
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  • Received : 02 Dec 2013
  • Accepted : 31 Jan 2014

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