Volume 91, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We conducted a prospective cohort study in four hospitals in Lima, Peru in infants with a birth weight ≤ 1,500 g followed from birth hospital discharge up to 1 year of age to determine the incidence of respiratory syncytial virus (RSV) hospitalizations. We enrolled 222 infants from March of 2009 to March of 2010: 48 infants with a birth weight < 1,000 g and 174 infants with a birth weight of 1,000–1,500 g (birth weight = 1,197 ± 224 g; gestational age = 30.1 ± 2.6 weeks). There were 936 episodes of respiratory infections; the incidence of respiratory infections during the first 1 year of life was 5.7 episodes/child-years. The incidence of RSV respiratory infections that required emergency room management was 103.9 per 1,000 child-years, and the incidence of RSV hospitalizations was 116.2 per 1,000 child-years (244.9 in infants with a birth weight < 1,000 g and 88.9 in infants 1,000–1,500 g; < 0.05). The incidence of RSV respiratory infections that required emergency management or hospitalization is high among pre-mature infants in Lima.


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  1. Nair H, Verma VR, Theodoratou E, Zgaga L, Huda T, Simões EA, Wright PF, Rudan I, Campbell H, , 2011. An evaluation of the emerging interventions against Respiratory Syncytial Virus (RSV)-associated acute lower respiratory infections in children. BMC Public Health 11 (Suppl 3): S30.[Crossref]
  2. Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, O'Brien KL, Roca A, Wright PF, Bruce N, Chandran A, Theodoratou E, Sutanto A, Sedyaningsih ER, Ngama M, Munywoki PK, Kartasasmita C, Simões EA, Rudan I, Weber MW, Campbell H, , 2010. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 375: 15451555.[Crossref]
  3. Alonso WJ, Laranjeira BJ, Pereira SA, Florencio CM, Moreno EC, Miller MA, Giglio R, Schuck-Paim C, Moura FE, , 2012. Comparative dynamics, mordibity and mortality burden of pediatric viral respiratory infections in an equatorial city. Pediatr Infect Dis J 31: e9e14.[Crossref]
  4. Viegas M, Barrero PR, Maffey AF, Mistchenko AS, , 2004. Respiratory viruses seasonality in children under five years of age in Buenos Aires, Argentina: a five-year analysis. J Infect 49: 222228.[Crossref]
  5. Avendaño LF, Palomino MA, Larrañaga C, , 2003. Surveillance for respiratory syncytial virus in infants hospitalized for acute lower respiratory infection in Chile (1989 to 2000). J Clin Microbiol 41: 48794882.[Crossref]
  6. Miller EK, Bugna J, Libster R, Shepherd BE, Scalzo PM, Acosta PL, Hijano D, Reynoso N, Batalle JP, Coviello S, Klein MI, Bauer G, Benitez A, Kleeberger SR, Polack FP, , 2012. Human rhinoviruses in severe respiratory disease in very low birth weight infants. Pediatrics 129: e60e67.[Crossref]
  7. Klein MI, Coviello S, Bauer G, Benitez A, Serra ME, Schiatti MP, Delgado MF, Melendi GA, Novalli L, Pena HG, Karron RA, Kleeberger SR, Polack FP, , 2006. The impact of infection with human metapneumovirus and other respiratory viruses in young infants and children at high risk for severe pulmonary disease. J Infect Dis 193: 15441551.[Crossref]
  8. Langley GF, Anderson LJ, , 2011. Epidemiology and prevention of respiratory syncytial virus infections among infants and young children. Pediatr Infect Dis J 30: 510517.
  9. Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, Auinger P, Griffin MR, Poehling KA, Erdman D, Grijalva CG, Zhu Y, Szilagyi P, , 2009. The burden of respiratory syncytial virus infections in young children. N Engl J Med 360: 588598.[Crossref]
  10. Sommer C, Resch B, Simões EA, , 2011. Risk factors for severe respiratory syncytial virus lower respiratory tract infection. Open Microbiol J 5: 144154.[Crossref]
  11. Colosia AD, Masaquel A, Hall CB, Barrett AM, Mahadevia PJ, Yogev R, , 2012. Residential crowding and severe respiratory syncytial virus disease among infants and young children: a systematic literature review. BMC Infect Dis 12: 95.[Crossref]
  12. Welliver R, , 2009. The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus. Paediatr Respir Rev 10 (Suppl 1): 68.[Crossref]
  13. Zachariah P, Shah S, Gao D, Simões EA, , 2009. Predictors of the durations of the respiratory syncytial virus season. Pediatr Infect Dis J 28: 772776.[Crossref]
  14. Panozzo CA, Stockman LJ, Curns AT, Anderson LJ, , 2010. Use of respiratory syncytial virus surveillance data to optimize the timing of immunoprophylaxis. Pediatrics 126: e116e123.[Crossref]
  15. Moura FE, Nunes IF, Silva GB, Jr Siqueira MM, , 2006. Respiratory syncytial virus infections in northeastern Brazil: seasonal trends and general aspects. Am J Trop Med Hyg 74: 165167.
  16. Laurent C, Dugué AE, Brouard J, Nimal D, Dina J, Parienti JJ, Vebret A, , 2012. Viral epidemiology and severity of respiratory infections in infants in 2009: a prospective study. Pediatr Infect Dis J 31: 827831.[Crossref]

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  • Received : 05 Dec 2013
  • Accepted : 04 Jul 2014

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