Volume 90, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Haitian children were monitored longitudinally in a filariasis study. Included were stool samples examined for and cysts, and serum specimens analyzed for immunoglobulin G (IgG) responses to eight recombinant antigens from (variant-specific surface protein [VSP1–VSP5]), (lectin adhesion molecule [LecA]), and (17- and 27-kDa) using a multiplex bead assay. The IgG responses to VSP antigens peaked at 2 years of age and then diminished and were significantly lower ( < 0.002) in children > 4.5 years than in children < 4.5 years. The IgG responses to tended to increase with age. The IgG responses to LecA and VSP antigens and the prevalence of stools positive for cysts were significantly higher ( < 0.037 and < 0.035, respectively) in the rainy season than in the dry season. The multiplex bead assay provides a powerful tool for analyzing serologic responses to multiple pathogens.


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  • Received : 20 Sep 2013
  • Accepted : 06 Jan 2014
  • Published online : 02 Apr 2014

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