Volume 91, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Our objective was to determine the seroprevalence of infection among mothers and children in two rural Mayan communities in Yucatan, Mexico and examine sociodemographic characteristics and adverse reproductive outcomes associated with maternal infection. We performed household surveys in the communities of Sudzal and Teya. Mothers were interviewed, and blood samples were obtained to perform rapid tests and enzyme-linked immunosorbent assays (ELISAs). We surveyed 390 mothers and 685 children. The overall seroprevalence was 2.3% among mothers and 0.4% among children. In Sudzal, we found a seroprevalence of 4.4% among mothers and 0.7% in children. In Teya, we found a seroprevalence of 0.9% among mothers and 0.3% among children. Compared with uninfected mothers, seropositive mothers reported more stillbirths (relative risk = 4.7; 95% confidence interval = 2.1–10.4). infection is present in these communities, and infected children indicate active transmission. Seropositivity in mothers is associated with a history of adverse reproductive outcomes.


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  1. Schofield CJ, Jannin J, Salvatella R, , 2006. The future of Chagas disease control. Trends Parasitol 22: 583588.[Crossref] [Google Scholar]
  2. Prata A, , 2001. Clinical and epidemiological aspects of Chagas disease. Lancet Infect Dis 1: 92100.[Crossref] [Google Scholar]
  3. Carlier Y, Truyens C, Deloron P, Peyron F, , 2012. Congenital parasitic infections: a review. Acta Trop 121: 5570.[Crossref] [Google Scholar]
  4. Blanco SB, Segura EL, Cura EN, Chuit R, Tulián L, Flores I, Garbarino G, Villalonga JF, Gürtler RE, , 2000. Congenital transmission of Trypanosoma cruzi: an operational outline for detecting and treating infected infants in north-western Argentina. Trop Med Int Health 5: 293301.[Crossref] [Google Scholar]
  5. Bittencourt AL, Barbosa HS, , 1972. Importance of the study of the macerated fetus for the diagnosis of congenital Chagas' disease. Rev Inst Med Trop Sao Paulo 14: 260263. [Google Scholar]
  6. Dumonteil E, , 1999. Update on Chagas' disease in Mexico. Salud Publica Mex 42: 322327. [Google Scholar]
  7. Barrera-Perez M, Rodriguez-Felix E, Guzman-Marin E, Zavala-Velazquez J, , 1990. La enfermedad de Chagas en el estado de Yucatán. Revision de casos clinicos en fase aguda de 1970–1989. Rev Biomed 1: 185195. [Google Scholar]
  8. Barrera-Perez M, Rodriguez-Felix E, Guzman-Marin E, Zavala-Velazquez J, , 1992. Prevalencia de la enfermedad de Chagas en el estado de Yucatán. Rev Biomed 3: 133139. [Google Scholar]
  9. Zavala-Castro JE, Gutierrez-Flota H, Barrera-Perez MA, Bolio-Solis A de J, Zavala-Velazquez JE, , 1995. Chronic Chagas cardiomyopathy detected in patients at the Regional General Hospital O'Horan, Merida, Yucatán, Mexico. Arch Inst Cardiol Mex 65: 541545. [Google Scholar]
  10. Velasco-Castrejon O, Valdespino JL, Tapia-Conyer R, Salvatierra B, Guzmán-Bracho C, Magos-lópez C, Llausás A, Gutiérrez G, Sepúlveda J, , 1992. Seroepidemiologia de la enfermedad de Chagas en México. Salud Publica Mex 34: 186196.[Crossref] [Google Scholar]
  11. Farfan-Ale J, Loroño-Pino M, Flores-Flores L, Rosado-Paredes E, Arjona-Torres A, , 1992. Prevalencia de anticuerpos contra Toxoplasma gondii y Trypanosoma cruzi en el estado de Yucatán. Rev Biomed 3: 812. [Google Scholar]
  12. Zavala-Velázquez JE, , 2003. La enfermedad de Chagas en el Estado de Yucatán, México (1940–2002). Rev Biomed 14: 3543. [Google Scholar]
  13. Guzman-Marin E, Barrera-Perez M, Rodriguez-Felix E, Zavala-Velazquez J, , 1992. Habito biológico de Triatoma dimidiata en el estado de Yucatán. Rev Biomed 3: 125131. [Google Scholar]
  14. Dumonteil E, Gourbière S, Barrera-Pérez M, Rodriguez-Félix E, Ruiz-Piña H, Baños-Lopéz O, Ramirez-Sierra MJ, Menu F, Rabinovich J, , 2002. Geographic distribution of Triatoma dimidiata and transmission dynamics of Trypanosoma cruzi in the Yucatán Península of México. Am J Trop Med Hyg 67: 176183. [Google Scholar]
  15. Gourbière S, Dorn P, Tripet F, Dumonteil E, , 2012. Genetic and evolution of triatomines: from phylogeny to vector control. Heredity 108: 190202.[Crossref] [Google Scholar]
  16. Dorn P, Buekens P, Hanford E, , 2007. Whac-a-mole: future trends in Chagas transmission and the importance of a global perspective on disease control. Future Microbiol 2: 365367.[Crossref] [Google Scholar]
  17. Buekens P, Almendares O, Carlier Y, Dumonteil E, Eberhard M, Gamboa-Leon R, James M, Padilla N, Wesson D, Xiong X, , 2008. Mother-to-child transmission of Chagas' disease in North America: why don't we do more? Matern Child Health J 12: 283286.[Crossref] [Google Scholar]
  18. Sosa-Estani S, Gamboa-León MR, Del Cid-Lemus J, Althabe F, Alger J, Almendares O, Cafferata ML, Chippaux JP, Dumonteil E, Gibbons L, Padilla-Raygoza N, Schneider D, Belizan JM, Buekens P, Working Group; , 2008. Short report: use of a rapid test on umbilical cord blood to screen for Trypanosoma cruzi infection in pregnant women in Argentina, Bolivia, Honduras, and México. Am J Trop Med Hyg 79: 755759. [Google Scholar]
  19. Gamboa-León R, Gonzalez-Ramirez C, Padilla-Raygoza N, Sosa-Estani S, Caamal-Kantun A, Buekens P, Dumonteil E, , 2011. Do commercial serologic tests for Trypanosoma cruzi infection detect Mexican strains in women and newborns? J Parasitol 97: 338343.[Crossref] [Google Scholar]
  20. Dumonteil E, Gourbiére S, , 2004. Predicting Triatoma dimidiata abundance and infection rate: a risk map for natural transmission of Chagas disease in the Yucatán peninsula of Mexico. Am J Trop Med Hyg 70: 514519. [Google Scholar]
  21. INEGI, 2005. II Conteo de población y vivienda 2005. Available at: http://www.inegi.gob.mx/est/contenidos/espanol/sistemas/conteo2005/iter2005/selentcampo.asp. Accessed November 27, 2007.
  22. Vanden Eng JL, Wolkon A, Frolov AS, Terlouw DJ, Eliades MJ, Morgah K, Takpa V, Dare A, Sodahlon YK, Doumanou Y, Hawley WA, Hightower AW, , 2007. Use of handheld computers with global positioning systems for probability sampling and data entry in household surveys. Am J Trop Med Hyg 77: 393399. [Google Scholar]
  23. Umezawa ES, Bastos SF, Coura JR, Levin MJ, Gonzalez A, Rangel-Aldao R, Zingales B, Luquetti AO, Franco da Silveira J, , 2003. An improved serodiagnostic test for Chagas' disease employing a mixture of Trypanosoma cruzi recombinant antigens. Transfusion 43: 9197.[Crossref] [Google Scholar]
  24. Ponce C, Ponce E, Vinelli E, Montoya A, de Aguilar V, Gonzalez A, Zingales B, Rangel-Aldao R, Levin MJ, Esfandiari J, Umezawa ES, Luquetti AO, da Silveira JF, , 2005. Validation of a rapid and reliable test for diagnosis of Chagas' disease by detection of Trypanosoma cruzi-specific antibodies in blood of donors and patients in Central America. J Clin Microbiol 43: 50655068.[Crossref] [Google Scholar]
  25. Verani JR, Seitz A, Gilman RH, LaFuente C, Galdos-Cardenas G, Kawai V, de LaFuente E, Ferrufino L, Bowman NM, Pinedo-Cancino V, Levy MZ, Steurer F, Todd CW, Kirchhoff LV, Cabrera L, Verastegui M, Bern C, , 2009. Geographic variation in the sensitivity of recombinant antigen-based rapid test for chronic Trypanosoma cruzi infection. Am J Trop Med Hyg 80: 410415. [Google Scholar]
  26. Dean AG, Sullivan KM, Soe MM, , 2013. OpenEpi: Open Source Epidemiologic Statistics for Public Health, Version 2.3.1. Available at: www.OpenEpi.com. Accessed January 7, 2013. [Google Scholar]
  27. Aras R, Veiga M, Gomes I, Mata G, Rodrigues B, Rabelo R, Guzman-Bracho C, Melo A, , 2002. Prevalence of Chagas' disease in Mulungu do Morro northeastern Brazil. Arq Bras Cardiol 78: 441443.[Crossref] [Google Scholar]
  28. Cruz-Reyes A, Pickering-López JM, , 2006. Chagas disease in Mexico: an analysis of geographical distribution during the past 76 years—a review. Mem Inst Oswaldo Cruz 101: 345354.[Crossref] [Google Scholar]
  29. Monteon V, Alducin C, Hernández J, Ramos-Ligonio A, Lopez R, , 2013. High frequency of human blood in Triatoma dimidiata captured inside dwellings in a rural community in the Yucatan peninsula, Mexico, but low antibody seroprevalence and electrocardiographic findings compatible with Chagas disease in humans. Am J Trop Med Hyg 88: 566571.[Crossref] [Google Scholar]
  30. Mjihdi A, Lambot MA, Stewart IJ, Detournay O, Noél JC, Carlier Y, Truyens C, , 2002. Acute Trypanosoma cruzi infection in mouse induces infertility or placental parasite invasion and ischemic necrosis associated with massive fetal loss. Am J Pathol 161: 676680.[Crossref] [Google Scholar]
  31. Truyens C, Mjihdi K, Lambot MA, Rivera MT, Noël JC, Carlier Y, , 2005. Efecto de la infección aguda y crónica por Trypanosoma cruzi en la gestación de los ratones. Rev Soc Bras Med Trop 38 (Suppl 2): 6872. [Google Scholar]
  32. Carlier Y, Rivera MT, Truyens C, Puissant F, Milaire J, , 1987. Interactions between chronic murine Trypanosoma cruzi infection and pregnancy: fetal growth retardation. Am J Trop Med Hyg 37: 534540. [Google Scholar]
  33. Cencig S, Coltel N, Truyens C, Carlier Y, , 2013. Fertility, gestation outcome and parasite congenital transmissibility in mice infected with TcI, TcII and TcVI genotypes of Trypanosoma cruzi . PLoS Negl Trop Dis 7: 111.[Crossref] [Google Scholar]
  34. Grieves JL, Hubbard GB, Williams JT, VandeBerg JL, Dick EJ, Jr López-Alvarenga JC, Schlabritz-Loutsevitch NE, , 2008. Trypanosoma cruzi in non-human primates with a history of stillbirths: a retrospective study (Papio hamadryas spp.) and case report (Macaca fascicularis). J Med Primatol 37: 318328.[Crossref] [Google Scholar]
  35. Carlier Y, Truyens C, Telleria J, Tibayrenc M, , 2010. Maternal-fetal transmission of Trypanosoma cruzi . , eds. American Trypanosomiasis Chagas Disease, One Hundred Years of Research, 1st Ed. Amsterdam, The Netheralands: Elsevier, 539580. [Google Scholar]
  36. Hernandez-Matheson IM, Frankowski RF, Held B, , 1983. Foeto-maternal morbidity in the presence of anitodies to Trypanosoma cruzi . Trans R Soc Trop Med Hyg 77: 405411.[Crossref] [Google Scholar]
  37. Torrico F, Alonso-Vega C, Suarez E, Rodriguez P, Torrico MC, , 2004. Maternal Trypanosoma cruzi infection, pregnancy outcome, morbidity, and mortality of congenitally infected and non-infected newborns in Bolivia. Am J Trop Med Hyg 70: 201209. [Google Scholar]
  38. de Andrade AL, Zicker F, de Oliveira RM, Almaieda Silva S, Luquetti A, Travassos LR, Almeida IC, de Andrade SS, de Andrade JG, Martelli CM, , 1996. Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. Lancet 348: 14071413.[Crossref] [Google Scholar]
  39. Sosa S, Segura EL, Ruiz AM, Velazquez E, Porcel BM, Yampotis C, , 1998. Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease. Am J Trop Med Hyg 59: 526529. [Google Scholar]
  40. Sosa-Estani S, Segura EL, , 2006. Etiological treatment in patients infected by Trypanosoma cruzi: experiences in Argentina. Curr Opin Infect Dis 19: 583587.[Crossref] [Google Scholar]
  41. Dumonteil E, Ramirez-Sierra MJ, Ferral J, Euan-Garcia M, Chavez-Nuñez L, , 2009. Usefulness of community participation for the fine temporal monitoring of house infestation by non-domiciliated triatomines. J Parasitol 95: 469471.[Crossref] [Google Scholar]
  42. Petherick A, , 2010. Campaigning for Chagas disease. Nature 465: S10S11.[Crossref] [Google Scholar]

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  • Received : 11 Sep 2013
  • Accepted : 10 May 2014
  • Published online : 06 Aug 2014

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