1921
Volume 91, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Anaplasmosis is an emerging infectious disease caused by infection with the bacterium . In the eastern United States, is transmitted to hosts through the bite of the blacklegged tick, . We determined the realized reservoir competence of 14 species of common vertebrate hosts for ticks by establishing the probability that each species transmits two important strains of ( human-active, which causes human cases, and variant 1, which does not) to feeding larval ticks. We also sampled questing nymphal ticks from ∼150 sites in a single county over 2 years and sampled over 6 years at one location. White-footed mice () and Eastern chipmunks () were the most competent reservoirs for infection with the human-active strain. Across the county, prevalence in ticks for both strains together was 8.3%; ticks were more than two times as likely to be infected with human-active as variant 1.

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2014-08-06
2017-09-21
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References

  1. Centers for Disease Control, 2013. Statistics and Epidemiology. Available at: http://www.cdc.gov/anaplasmosis/stats/. Accessed August 20, 2013.
  2. McQuiston JH, Paddock CD, Holman RC, Childs JE, , 1999. The human ehrlichioses in the United States. Emerg Infect Dis 5: 635642.[Crossref]
  3. Demma LJ, Holman RC, McQuiston JH, Krebs JW, Swerdlow DL, , 2005. Epidemiology of human ehrlichiosis and anaplasmosis in the United States, 2001–2002. Am J Trop Med Hyg 73: 400409.
  4. Ogden NH, Brown K, Horrocks BK, Woldehiwet Z, Bennett M, , 1998. Granulocytic ehrlichia infection in ixodid ticks and mammals in woodlands and uplands of the U.K. Med Vet Entomol 12: 423429.[Crossref]
  5. Petrovec M, Bidovec A, Sumner JW, Nicholson WL, Childs JE, Avšič-Županc T, , 2002. Infection with Anaplasma phagocytophila in cervids from Slovenia: evidence of two genotype lineages. Wien Klin Wochenschr Middle Eur J Med 114: 641647.
  6. Cao W, Zhao Q, Zhang P, Yang H, Wu X, Wen B, Zhang X, Habbema JDF, , 2003. Prevalance of Anaplasma phagocytophila and Borrelia burgdorferi in Ixodes persulcatus ticks from northeastern China. Am J Trop Med Hyg 68: 547550.
  7. Cao W, Zhan L, He J, Foley JE, De Vlas SJ, Wu X, Yang H, Richardus JH, Habbema JDF, , 2006. Natural Anaplasma phagocytophilum infection of ticks and rodents from a forest area of Jilin Province, China. Am J Trop Med Hyg 75: 664668.
  8. Kim CM, Yi YH, Yu DH, Lee MJ, Cho MR, Desai AR, Shringi S, Klein TA, Kim HC, Song JW, Baek LJ, Chong ST, O'guinn ML, Lee JS, Lee IY, Park JH, Foley J, Chae JS, , 2006. Tick-borne rickettsial pathogens in ticks and small mammals in Korea. Appl Environ Microbiol 72: 57665776.[Crossref]
  9. Ramsey AH, Belongia EA, Gale CM, Davis JP, , 2002. Outcomes of treated human granulocytic ehrlichiosis cases. Emerg Infect Dis 8: 398401.[Crossref]
  10. Jin H, Wei F, Liu Q, Qian J, , 2012. Epidemiology and control of human granulocytic anaplasmosis: a systematic review. Vector Borne Zoonotic Dis 12: 269274.[Crossref]
  11. Chowdri HR, Gugliotta JL, Berardi VP, Goethert HK, Molloy PJ, Sterling SL, Telford SR, , 2013. Borrelia miyamotoi infection presenting as human granulocytic anaplasmosis: a case report. Ann Intern Med 159: 2127.[Crossref]
  12. Dahlgren FS, Mandel EJ, Krebs JW, Massung RF, McQuiston JH, , 2011. Increasing incidence of Ehrlichia chaffeensis and Anaplasma phagocytophilum in the United States, 2000–2007. Am J Trop Med Hyg 85: 124.[Crossref]
  13. Bakken JS, Krueth J, Wilson-Nordskog C, Tilden RL, Asanovich K, Dumler JS, , 1996. Clinical and laboratory characteristics of human granulocytic ehrlichiosis. JAMA 275: 199205.[Crossref]
  14. Dumler JS, Choi KS, Garcia-Garcia JC, Barat NS, Scorpio DG, Garyu JW, Grab DJ, Bakken JS, , 2005. Human granulocytic anaplasmosis and Anaplasma phagocytophilum . Emerg Infect Dis 11: 18281834.[Crossref]
  15. Hodzic E, Fish D, Maretzki CM, De Silva AM, Feng S, Barthold SW, , 1998. Acquisition and transmission of the agent of human granulocytic ehrlichiosis by Ixodes scapularis ticks. J Clin Microbiol 36: 35743578.
  16. Kramer VL, Randolph MP, Hui LT, Irwin WE, Gutierrez AG, Vugia DJ, , 1999. Detection of the agents of human ehrlichioses in ixodid ticks from California. Am J Trop Med Hyg 60: 6265.
  17. Walls JJ, Greig B, Neitzel DF, Dumler JS, , 1997. Natural infection of small mammal species in Minnesota with the agent of human granulocytic ehrlichiosis. J Clin Microbiol 35: 853855.
  18. Nicholson WL, Muir S, Sumner JW, Childs JE, , 1998. Serologic evidence of infection with Ehrlichia spp. in wild rodents (Muridae: Sigmodontinae) in the United States. J Clin Microbiol 36: 695700.
  19. Nicholson WL, Castro MB, Kramer VI, Sumner JW, Childs JE, , 1999. Dusky-footed wood rats (Neotoma fuscipes) as reservoirs of granulocytic ehrlichiae (Rickettsiales: Ehrlichieae) in northern California. J Clin Microbiol 37: 33233327.
  20. Magnarelli LA, Ijdo JW, Stafford KC, III Fikrig E, , 1999. Infections of granulocytic ehrlichiae and Borrelia burgdorferi in white-tailed deer in Connecticut. J Wildl Dis 35: 266274.[Crossref]
  21. Levin ML, Nicholson WL, Massung RF, Sumner JW, Fish D, , 2002. Comparison of the reservoir competence of medium-sized mammals and Peromyscus leucopus for Anaplasma phagocytophilum in Connecticut. Vector Borne Zoonotic Dis 2: 125136.[Crossref]
  22. Goethert HK, Telford SR, III, 2003. Enzootic transmission of the agent of human granulocytic ehrlichiosis among cottontail rabbits. Am J Trop Med Hyg 68: 633637.
  23. Dugan VG, Yabsley MJ, Tate CM, Mead DG, Munderloh UG, Herron MJ, Stallknecht DE, Little SE, Davidson WR, , 2006. Evaluation of white-tailed deer (Odocoileus virginianus) as natural sentinels for Anaplasma phagocytophilum . Vector Borne Zoonotic Dis 6: 192207.[Crossref]
  24. Foley J, Nieto NC, Madigan J, Sykes J, , 2008. Possible differential host tropism in Anaplasma phagocytophilum strains in the western United States. Ann N Y Acad Sci 1149: 9497.[Crossref]
  25. Keesing F, Hersh MH, Tibbetts M, McHenry DJ, Duerr S, Brunner J, Killilea M, LoGiudice K, Schmidt KA, Ostfeld RS, , 2012. Reservoir competence of vertebrate hosts for Anaplasma phagocytophilum . Emerg Infect Dis 18: 20132016.[Crossref]
  26. Levin ML, Fish D, , 2000. Acquisition of coinfection and simultaneous transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis ticks. Infect Immun 68: 21832186.[Crossref]
  27. Belongia EA, Reed KD, Mitchell PD, Kolbert CP, Persing DH, Gill JS, Kazmierczak JK, , 1997. Prevalence of granulocytic ehrlichia infection among white-tailed deer in Wisconsin. J Clin Microbiol 35: 14651468.
  28. de la Fuente J, Massung RF, Wong SJ, Chu FK, Lutz H, Meli M, Loewenich FD, Grzeszczuk A, Torina A, Caracappa S, Mangold AJ, Naranjo V, Stuen S, Kocan KM, , 2005. Sequence analysis of the msp4 gene of Anaplasma phagocytophilum strains. J Clin Microbiol 43: 13091317.[Crossref]
  29. Massung RF, Priestley RA, Miller NJ, Mather TN, Levin ML, , 2003. Inability of a variant strain of Anaplasma phagocytophilum to infect mice. J Infect Dis 188: 17571763.[Crossref]
  30. Massung RF, Mather TN, Priestley RA, Levin ML, , 2003. Transmission efficiency of the AP-variant 1 strain of Anaplasma phagocytophila . Ann N Y Acad Sci 990: 7579.[Crossref]
  31. Rejmanek D, Bradburd G, Foley J, , 2012. Molecular characterization reveals distinct genospecies of Anaplasma phagocytophilum from diverse North American hosts. J Med Microbiol 61: 204212.[Crossref]
  32. Massung RF, Courtney JW, Hiratzka SL, Pitzer VE, Smith G, Dryden RL, , 2005. Anaplasma phagocytophilum in white-tailed deer. Emerg Infect Dis 11: 16041606.[Crossref]
  33. Hersh MH, Tibbetts M, Strauss M, Ostfeld RS, Keesing F, , 2012. Reservoir competence of wildlife host species for Babesia microti . Emerg Infect Dis 18: 19511957.[Crossref]
  34. Keesing F, Brunner J, Duerr S, Killilea M, LoGiudice K, Schmidt K, Vuong H, Ostfeld RS, , 2009. Hosts as ecological traps for the vector of Lyme disease. Proc Biol Sci 276: 39113919.[Crossref]
  35. Ostfeld RS, Canham CD, Oggenfuss K, Winchcombe RJ, Keesing F, , 2006. Climate, deer, rodents, and acorns as determinants of variation in Lyme-disease risk. PLoS Biol 4: e145.[Crossref]
  36. Courtney JW, Kostelnik LM, Zeidner NS, Massung RF, , 2004. Multiplex real-time PCR for detection of Anaplasma phagocytophilum and Borrelia burgdorferi . J Clin Microbiol 42: 31643168.[Crossref]
  37. Massung RF, Slater K, Owens JH, Nicholson WL, Mather TN, Solberg VB, Olson JG, , 1998. Nested PCR assay for detection of granulocytic ehrlichiae. J Clin Microbiol 36: 10901095.
  38. Brunner JL, LoGiudice K, Ostfeld RS, , 2008. Estimating reservoir competence of Borrelia burgdorferi hosts: prevalence and infectivity, sensitivity, and specificity. J Med Entomol 45: 139147.[Crossref]
  39. Levin ML, Fish D, , 2000. Immunity reduces reservoir host competence of Peromyscus leucopus for Ehrlichia phagocytophila . Infect Immun 68: 15141518.[Crossref]
  40. Sun W, Ijdo JW, Telford SR, Hodzic E, Zhang Y, Barthold SW, Fikrig E, Telford SR, III, 1997. Immunization against the agent of Human Granulocytic Ehrlichiosis in a murine model. J Clin Invest 100: 30143018.[Crossref]
  41. Hodzic E, Fish D, Maretzki CM, De Silva AM, Feng S, Barthold SW, , 1998. Acquisition and transmission of the agent of human granulocytic ehrlichiosis by Ixodes scapularis ticks. J Clin Microbiol 36: 35743578.
  42. LoGiudice K, Ostfeld RS, Schmidt KA, Keesing F, , 2003. The ecology of infectious disease: effects of host diversity and community composition on Lyme disease risk. Proc Natl Acad Sci USA 100: 567571.[Crossref]
  43. Courtney JW, Dryden RL, Montgomery J, Schneider BS, Smith G, Massung RF, , 2003. Molecular characterization of Anaplasma phagocytophilum and Borrelia burgdorferi in Ixodes scapularis ticks from Pennsylvania. J Clin Microbiol 41: 15691573.[Crossref]
  44. Steiner FE, Pinger RR, Vann CN, Grindle N, Civitello D, Clay K, Fuqua C, , 2008. Infection and co-infection rates of Anaplasma phagocytophilum variants, Babesia spp., Borrelia burgdorferi, and the rickettsial endosymbiont in Ixodes scapularis (Acari: Ixodidae) from sites in Indiana, Maine, Pennsylvania, and Wisconsin. J Med Entomol 45: 289297.[Crossref]
  45. LoGiudice K, Duerr ST, Newhouse MJ, Schmidt KA, Killilea ME, Ostfeld RS, , 2008. Impact of host community composition on Lyme disease risk. Ecology 89: 28412849.[Crossref]
  46. Ostfeld RS, , 2011. Lyme Disease: The Ecology of a Complex System. Oxford, United Kingdom: Oxford University Press.
  47. Dunning Hotopp JC, Lin M, Madupu R, Crabtree J, Angiuoli SV, Eisen JA, Seshadri R, Ren Q, Wu M, Utterback TR, Smith S, Lewis M, Khouri H, Zhang C, Niu H, Lin Q, Ohashi N, Zhi N, Nelson W, Brinkac LM, Dodson RJ, Rosovitz MJ, Sundaram J, Daugherty SC, Davidsen T, Durkin AS, Gwinn M, Haft DH, Selengut JD, Sullivan SA, Zafar N, Zhou L, Benahmed F, Forberger H, Halpin R, Mulligan S, Robinson J, White O, Rikihisa Y, Tettelin H, , 2006. Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet 2: e21.[Crossref]
  48. Barbet AF, Lundgren AM, Alleman AR, Stuen S, Bjöersdorff A, Brown RN, Drazenovich NL, Foley JE, , 2006. Structure of the expression site reveals global diversity in MSP2 (P44) variants in Anaplasma phagocytophilum . Infect Immun 74: 64296437.[Crossref]
  49. Scharf W, Schauer S, Freyburger F, Petrovec M, Schaarschmidt-Kiener D, Liebisch G, Runge M, Ganter M, Kehl A, Dumler JS, Garcia-Perez AL, Jensen J, Fingerle V, Meli ML, Ensser A, Stuen S, von Loewenich FD, , 2011. Distinct host species correlate with Anaplasma phagocytophilum ankA gene clusters. J Clin Microbiol 49: 790796.[Crossref]
  50. Bown KJ, Lambin X, Ogden NH, Begon M, Telford G, Woldehiwet Z, Birtles RJ, , 2009. Delineating Anaplasma phagocytophilum ecotypes in coexisting, discrete enzootic cycles. Emerg Infect Dis 15: 19481954.[Crossref]
  51. Portillo A, Perez-Martinez L, Santibanez S, Santibanez P, Palomar AM, Oteo JA, , 2011. Anaplasma spp. in wild mammals and Ixodes ricinus from the North of Spain. Vector Borne Zoonotic Dis 11: 38.[Crossref]
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  • Received : 11 Sep 2013
  • Accepted : 17 Apr 2014

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