Volume 90, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Leptospirosis, caused by the spirochete bacterium spp. is a zoonosis, distributed worldwide and classified as an emerging infectious disease. Fatal outcomes to leptospiral infection do occur and the disease can cause abortion and other reproductive problems in cattle, goats, and pigs. In humans the symptoms range from subclinical infection to acute febrile illness, pulmonary hemorrhage and renal failure. Leptospirosis has never been officially reported to the World Health Organization (WHO) or the World Animal Health Organization in animals or humans in Uganda. However, favorable ecological conditions and suitable animal hosts can be found within the country. A commercially available enzyme-linked immunosorbent (ELISA) kit was used to screen sera samples from domesticated cattle and African buffalo () at two locations in southwestern Uganda, collected over a 4-year period. Positive samples were found in both cattle and African buffalo samples, from both locations and across the sampling period. Overall seroprevalence was 42.39% in African buffalo and 29.35% in cattle.


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  1. Adler B, de la Peña Moctezuma A, , 2010. Leptospira and leptospirosis. Vet Microbiol 140: 287296.[Crossref] [Google Scholar]
  2. Lau CL, Smythe LD, Craig SB, Weinstein P, , 2010. Climate change, flooding, urbanization and leptospirosis: fuelling the fire? Trans R Soc Trop Med Hyg 104: 631638.[Crossref] [Google Scholar]
  3. Levett PN, , 2001. Leptospirosis. Clin Microbiol Rev 14: 296326.[Crossref] [Google Scholar]
  4. The Center for Food Security & Public Health ISU, 2005. Leptospirosis. Available at: http://www.cfsph.iastate.edu/Factsheets/pdfs/leptospirosis.pdf, 7. Accessed February 4, 2012. [Google Scholar]
  5. Bharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA, Levett PN, Gilman RH, Willig MR, Gotuzzo E, Vinetz JM, Consortium P-USL; , 2003. Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis 3: 757771.[Crossref] [Google Scholar]
  6. Adler B, Lo M, Seemann T, Murray GL, , 2011. Pathogenesis of leptospirosis: the influence of genomics. Vet Microbiol 153: 7381.[Crossref] [Google Scholar]
  7. World Health Organization, 2003. Human Leptospirosis: Guidance for Diagnosis, Surveillance and Control. Available at: http://whqlibdoc.who.int/hq/2003/WHO_CDS_CSR_EPH_2002.23.pdf, 109. Accessed February 4, 2012. [Google Scholar]
  8. Lau C, Smythe L, Weinstein P, , 2010. Leptospirosis: an emerging disease in travelers. Travel Med Infect Dis 8: 3339.[Crossref] [Google Scholar]
  9. Levett P, , 2004. Leptospirosis: a forgotten zoonosis? Clin Appl Immunol Rev 4: 435448.[Crossref] [Google Scholar]
  10. ProMED-mail, 2004. Leptospirosis - Kenya (Bungoma). 20040616.1613. Available at: http://www.promedmail.org/. Accessed March 7, 2012. [Google Scholar]
  11. Biggs HM, Bui DM, Galloway RL, Stoddard RA, Shadomy SV, Morrissey AB, Bartlett JA, Onyango JJ, Maro VP, Kinabo GD, Saganda W, Crump JA, , 2011. Leptospirosis among hospitalized febrile patients in northern Tanzania. Am J Trop Med Hyg 85: 275281.[Crossref] [Google Scholar]
  12. Sebek Z, Sixl W, Reinthaler F, Abdel-Nabi O, Stünzner D, Schneeweiss W, Mascher F, Valova M, , 1989. Leptospirosis in the Melut district–upper Nile province (south Sudan)–an overview. Geogr Med Suppl 5: 161178. [Google Scholar]
  13. Van Riel J, Szpajshendler L, Van Riel M, , 1956. Clinical, bacteriological and epidemiological research on a new focus of leptospirosis in the Belgian Congo. Bull Soc Pathol Exot 49: 118143. [Google Scholar]
  14. Scolamacchia F, Handel IG, Fèvre EM, Morgan KL, Tanya VN, Bronsvoort BM, , 2010. Serological patterns of brucellosis, leptospirosis and Q fever in Bos indicus cattle in Cameroon. PLoS ONE 5: e8623.[Crossref] [Google Scholar]
  15. Thrusfield MV, , 2007. Veterinary Epidemiology. Oxford: Blackwell Science. [Google Scholar]
  16. Ball MG, , 1966. Animal hosts of leptospires in Kenya and Uganda. Am J Trop Med Hyg 15: 523530. [Google Scholar]
  17. Millan J, Chirife AD, Zikusoka-Kalema G, Cabezon O, Muro J, Marco I, Cliquet F, Vizcaino-Leon L, Wasniewski M, Almeria S, Mugisha L, , 2013. Serosurvey of dogs for human, livestock, and wildlife pathogens, Uganda. Emerg Infect Dis 19: 680682.[Crossref] [Google Scholar]
  18. Ministry of Health Program MC, 2005. Uganda Malaria Control Strategic Plan 2005/06–2009/2010. , ed. Uganda, 49. [Google Scholar]
  19. Ndyomugyenyi R, Magnussen P, Clarke S, , 2007. Diagnosis and treatment of malaria in peripheral health facilities in Uganda: findings from an area of low transmission in south-western Uganda. Malar J 6: 39.[Crossref] [Google Scholar]

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  • Received : 08 Aug 2013
  • Accepted : 08 Nov 2013
  • Published online : 05 Feb 2014

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