1921
Volume 90, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Epidemiologic studies of co-infection with tuberculosis (TB) and intestinal parasites in humans have not been extensively investigated in China. A cross-section study was conducted in a rural county of Henan Province, China. Pulmonary TB (PTB) case-patients receiving treatment for infection with and healthy controls matched for geographic area, age, and sex were surveyed by using questionnaires. Fecal and blood specimens were collected for detection of intestinal parasites, routine blood examination, and infection with human immunodeficiency virus. The chi-square test was used for univariate analysis and multivariate logistic regression models were used to adjust for potential confounding factors. A total of 369 persons with PTB and 366 healthy controls were included; all participants were negative for human immunodeficiency virus. The overall prevalence of intestinal parasites in persons with PTB was 14.9%, including intestinal protozoa (7.9%) and helminthes (7.6%). The infection spectrum of intestinal parasites was spp. (1.4%), (6.2%), (0.3%), (0.3%), (0.5%), (2.2%), and hookworm (4.6%). The prevalence of intestinal parasites showed no significant difference between persons with PTB and healthy controls after adjusting for potential confounding factors. There was no factor that affected infection rates for intestinal parasites between the two groups. Infection with intestinal parasites of persons with PTB was associated with female sex (adjusted odds ratio [AOR] = 2.05, 95% confidence interval [CI] = 1.01–4.17), body mass index ≤ 19 (AOR = 3.02, 95% CI = 1.47–6.20), and anemia (AOR = 2.43, 95% CI = 1.17–5.03). Infection of healthy controls was only associated with an annual labor time in farmlands > 2 months (AOR = 4.50, 95% CI = 2.03–10.00). In addition, there was no significant trend between rates of infection with intestinal parasites and duration of receiving treatment for infection with in persons with PTB. The prevalence of intestinal parasites was not higher in persons with PTB, and there was no evidence that PTB increased susceptibility to intestinal parasites in this study. However, for patients with PTB, women and patients with comorbidities were more likely to be infected with intestinal parasites.

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2014-01-08
2017-09-25
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References

  1. Manuel Ramos J, Reyes F, Tesfamariam A, , 2006. Intestinal parasites in adults admitted to a rural Ethiopian hospital: relationship to tuberculosis and malaria. Scand J Infect Dis 38: 460462.[Crossref]
  2. Abate E, Belayneh M, Gelaw A, Idh J, Getachew A, Alemu S, Diro E, Fikre N, Britton S, Elias D, Aseffa A, Stendahl O, Schon T, , 2012. The impact of asymptomatic helminth co-infection in patients with newly diagnosed tuberculosis in north-west Ethiopia. PLoS ONE 7: e42901.[Crossref]
  3. World Health Organization, 2011. Global Tuberculosis Control: WHO Report 2011. Geneva: World Health Organization, WHO/HTM/TB/2011.16.
  4. Disease Control Bureau of the Ministry of Health, Chinese Center for Disease Control and Prevention, 2011. Report on the Fifth National Tuberculosis Epidemiological Survey in China, 2010. Beijing, China: Military Medical Science Press.
  5. Tian LG, Chen JX, Wang TP, Cheng GJ, Steinmann P, Wang FF, Cai YC, Yin XM, Guo J, Zhou L, Zhou XN, , 2012. Co-infection of HIV and intestinal parasites in rural area of China. Parasit Vectors 5: 36.[Crossref]
  6. Tian LG, Wang TP, Lv S, Wang FF, Guo J, Yin XM, Cai YC, Dickey MK, Steinmann P, Chen JX, , 2013. HIV and intestinal parasite co-infections among a Chinese population: an immunological profile. Infect Dis Poverty 2: 18.[Crossref]
  7. Mofid LS, Bickle Q, Jiang JY, Du ZW, Patrick E, , 2011. Soil-transmitted helminthiasis in rural south-west China: prevalence, intensity and risk factor analysis. Southeast Asian J Trop Med Public Health 42: 513526.
  8. Tang N, Luo NJ, , 2003. A cross-sectional study of intestinal parasitic infections in a rural district of west China. Can J Infect Dis Med Microbiol 14: 159162.
  9. Resende Co T, Hirsch CS, Toossi Z, Dietze R, Ribeiro-Rodrigues R, , 2007. Intestinal helminth co-infection has a negative impact on both anti-Mycobacterium tuberculosis immunity and clinical response to tuberculosis therapy. Clin Exp Immunol 147: 4552.
  10. Vasil'ev AV, Shenderova RI, Ginzburg ZI, Vasil'ev VI, , 1989. Tuberculosis of the lungs complicated by opisthorchiasis under conditions of the extreme north, 1989. [in Russian]. Probl Tuberk 6: 4144.
  11. Kashuba EA, Rusakova LI, , 1992. Anthelmintic therapy of opisthorchiasis in patients with active tuberculosis [in Russian]. Probl Tuberk 3–4: 3336.
  12. Ferreira AP, Aguiar AS, Fava MW, Correa JO, Teixeira FM, Teixeira HC, , 2002. Can the efficacy of Bacille Calmette-Guerin tuberculosis vaccine be affected by intestinal parasitic infections? J Infect Dis 186: 441442, author reply 442–443.[Crossref]
  13. Elias D, Akuffo H, Pawlowski A, Haile M, Schon T, Britton S, , 2005. Schistosoma mansoni infection reduces the protective efficacy of BCG vaccination against virulent Mycobacterium tuberculosis . Vaccine 23: 13261334.[Crossref]
  14. Disease Control Bureau of the Ministry of Health, Department of Medical Administration of the Ministry of Health, Chinese Center for Disease Control and Prevention, 2009. Guidelines for Implementing the National Tuberculosis Control Program in China, 2008. Beijing, China: Peking Union Medical College Press.
  15. Lu Z, Zhong N, , 2008. Internal Medicine. Beijing, China: People's Medical Publishing House.
  16. Leelayoova S, Taamasri P, Rangsin R, Naaglor T, Thathaisong U, Mungthin M, , 2002. In-vitro cultivation: a sensitive method for detecting Blastocystis hominis . Ann Trop Med Parasitol 96: 803807.[Crossref]
  17. Katz N, Chaves A, Pellegrino J, , 1972. A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni . Rev Inst Med Trop Sao Paulo 14: 397400.
  18. Elias D, Mengistu G, Akuffo H, Britton S, , 2006. Are intestinal helminths risk factors for developing active tuberculosis? Trop Med Int Health 11: 551558.[Crossref]
  19. Elias D, Britton S, Kassu A, Akuffo H, , 2007. Chronic helminth infections may negatively influence immunity against tuberculosis and other diseases of public health importance. Expert Rev Anti Infect Ther 5: 475484.[Crossref]
  20. Li XX, Zhou XN, , 2013. Co-infection of tuberculosis and parasitic diseases in humans: a systematic review. Parasit Vectors 6: 79.[Crossref]
  21. Zheng Q, Chen Y, Zhang HB, Chen JX, Zhou XN, , 2009. The control of hookworm infection in China. Parasit Vectors 2: 44.[Crossref]
  22. Guo JD, Shen GJ, Wu WD, Li QY, Yin XM, Zhou L, Ji H, , 2004. Distribution and risk factors of Ascaris infection in Anhui Province [in Chinese]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 16: 456459.
  23. National Center for Tuberculosis Control and Prevention of Chinese Center for Disease Control and Prevention, 2005. Health Promotion Toolkit of Chinese Tuberculosis Control and Prevention. Available at: http://tb.chinacdc.cn/chinatb/chinatb1/index.htm.
  24. Aimpun P, Hshieh P, , 2004. Survey for intestinal parasites in Belize, Central America. Southeast Asian J Trop Med Public Health 35: 506511.
  25. Rathman G, Sillah J, Hill PC, Murray JF, Adegbola R, Corrah T, Lienhardt C, McAdam KP, , 2003. Clinical and radiological presentation of 340 adults with smear-positive tuberculosis in The Gambia. Int J Tuberc Lung Dis 7: 942947.
  26. Mahuad C, Bozza V, Pezzotto SM, Bay ML, Besedovsky H, del Rey A, Bottasso O, , 2007. Impaired immune responses in tuberculosis patients are related to weight loss that coexists with an immunoendocrine imbalance. Neuroimmunomodulation 14: 193199.[Crossref]
  27. Tian LG, Cheng GJ, Chen JX, Cai YC, Guo J, Tong XM, Liu Q, Zhou XN, , 2012. Survey on co-infection with HIV and intestinal parasites in high prevalence areas of HIV/AIDS, China [in Chinese]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 24: 168172.
  28. Gupta KB, Gupta R, Atreja A, Verma M, Vishvkarma S, , 2009. Tuberculosis and nutrition. Lung India 26: 916.[Crossref]
  29. Pawlowski ZS, , 1984. Implications of parasite-nutrition interactions from a world perspective. Fed Proc 43: 256260.
  30. Amare H, Gelaw A, Anagaw B, Gelaw B, , 2013. Smear positive pulmonary tuberculosis among diabetic patients at the Dessie referral hospital, Northeast Ethiopia. Infect Dis Poverty 2: 6.[Crossref]
  31. Mendez S, Traslavina R, Hinchman M, Huang L, Green P, Cynamon MH, Welch JT, , 2009. The antituberculosis drug pyrazinamide affects the course of cutaneous leishmaniasis in vivo and increases activation of macrophages and dendritic cells. Antimicrob Agents Chemother 53: 51145121.[Crossref]
  32. Conti R, Parenti F, , 1983. Rifampin therapy for brucellosis, flavobacterium meningitis, and cutaneous leishmaniasis. Rev Infect Dis 5 (Suppl 3): S600S605.[Crossref]
  33. Pukrittayakamee S, Viravan C, Charoenlarp P, Yeamput C, Wilson RJ, White NJ, , 1994. Antimalarial effects of rifampin in Plasmodium vivax malaria. Antimicrob Agents Chemother 38: 511514.[Crossref]
  34. Aditya NP, Patankar S, Madhusudhan B, , 2010. Assessment of in vivo antimalarial activity of rifampicin, isoniazide, and ethambutol combination therapy. Parasitol Res 106: 14811484.[Crossref]
  35. Araujo FG, Khan AA, Remington JS, , 1996. Rifapentine is active in vitro and in vivo against Toxoplasma gondii . Antimicrob Agents Chemother 40: 13351337.
  36. Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Albers A, Specht S, Klarmann U, Pfarr K, Adjei O, Hoerauf A, , 2011. Macrofilaricidal activity in Wuchereria bancrofti after 2 weeks treatment with a combination of rifampicin plus doxycycline. J Parasitol Res 2011: 201617.[Crossref]
  37. Rao R, Well GJ, , 2002. In vitro effects of antibiotics on Brugia malayi worm survival and reproduction. J Parasitol 88: 605611.[Crossref]
  38. Townson S, Tagboto S, McGarry HF, Egerton GL, Taylor MJ, , 2006. Onchocerca parasites and Wolbachia endosymbionts: evaluation of a spectrum of antibiotic types for activity against Onchocerca gutturosa in vitro . Filaria J 5: 4.[Crossref]
  39. Townson S, Hutton D, Siemienska J, Hollick L, Scanlon T, Tagboto SK, Taylor MJ, , 2000. Antibiotics and Wolbachia in filarial nematodes: antifilarial activity of rifampicin, oxytetracycline and chloramphenicol against Onchocerca gutturosa, Onchocerca lienalis and Brugia pahangi . Ann Trop Med Parasitol 94: 801816.[Crossref]
  40. Department of Services and Management of Migrant Population of the National Population and Family Planning Commission, 2012. Report in 2012 on China's Migrant Population Development. Beijing, China: China Population Publishing House.
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  • Received : 24 Jul 2013
  • Accepted : 30 Sep 2013

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