1921
Volume 90, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We conducted a case–control study to examine associations between parasite infection, including protozoa infection, and tuberculosis (TB) in children in Lima, Peru. We enrolled 189 matched-pairs. In multivariable conditional logistic regression analyses, infection (rate ratio = 0.30, 95% confidence interval = 0.14–0.64, = 0.002) was strongly associated with a lower risk of TB. We observed a statistically significant inverse linear dose-response relationship between infection and TB. These findings should be confirmed in future prospective studies.

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2014-02-05
2017-09-21
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References

  1. Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, Rudan I, Campbell H, Cibulskis R, Li M, Mathers C, Black RE, , 2012. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet 379: 21512161.[Crossref]
  2. Kublin JG, Patnaik P, Jere CS, Miller WC, Hoffman IF, Chimbiya N, Pendame R, Taylor TE, Molyneux ME, , 2005. Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study. Lancet 365: 233240.
  3. López-Gatell H, Cole SR, Hessol NA, French AL, Greenblatt RM, Landesman S, Preston-Martin S, Anastos K, , 2007. Effect of tuberculosis on the survival of women infected with human immunodeficiency virus. Am J Epidemiol 165: 11341142.[Crossref]
  4. Adegnika AA, Kremsner PG, , 2012. Epidemiology of malaria and helminth interaction: a review from 2001 to 2011. Current Opinion in HIV and AIDS 7: 221224.[Crossref]
  5. Rafi W, Ribeiro-Rodrigues R, Ellner JJ, Salgame P, , 2012. Coinfection-helminthes and tuberculosis. Current Opinion in HIV and AIDS 7: 239244.[Crossref]
  6. Elias D, Akuffo H, Britton S, , 2006. Helminthes could influence the outcome of vaccines against TB in the tropics. Parasite Immunol 28: 507513.[Crossref]
  7. Matowicka-Karna J, Dymicka-Piekarska V, Kemona H, , 2009. IFN-gamma, IL-5, IL-6 and IgE in patients infected with Giardia intestinalis . Folia Histochem Cytobiol 47: 9397.[Crossref]
  8. Ebert EC, , 1999. Giardia induces proliferation and interferon gamma production by intestinal lymphocytes. Gut 44: 342346.[Crossref]
  9. Franke MF, Del Castillo H, Pereda Y, Lecca L, Cárdenas L, Fuertes J, Murray MB, Bayona J, Becerra MC, , 2013. Modifiable factors associated with tuberculosis disease in children: a case-control study. Pediatr Infect Dis J. Sep 23 [Epub ahead of print].
  10. Pelly TF, Santillan CF, Gilman RH, Cabrera LZ, Garcia E, Vidal C, Zimic MJ, Moore DAJ, Evans CA, , 2005. Tuberculosis skin testing, anergy and protein malnutrition in Peru. Int J Tuberc Lung Dis 9: 977984.
  11. Iannacone J, Benites MJ, Chirinos L, , 2006. Prevalence of intestinal parasitic infection in primary school children of Santiago de Surco, Lima, Peru. Parasitología Latinoamericana 61: 5462.[Crossref]
  12. Graham CF, , 1941. A device for the diagnosis of Enterobius infection. Am J Trop Med Hyg 159161.
  13. Centers for Disease Control and Prevention, 2012. Parasites - Blastocystis spp. Infection - FAQs. Available at: http://www.cdc.gov/parasites/blastocystis/faqs.html. Accessed July 12, 2012.
  14. Coyle CM, Varughese J, Weiss LM, Tanowitz HB, , 2012. Blastocystis: to treat or not to treat…. Clin Infect Dis 54: 105110.[Crossref]
  15. Velasco J, González F, Díaz T, Peña-Guillén J, Araque M, , 2011. Profiles of enteropathogens in asymptomatic children from indigenous communities of Mérida, Venezuela. J Infect Dev Ctries 5: 278285.
  16. Perry S, De Jong BC, Solnick JV, De la Luz Sanchez M, Yang S, Lin PL, Hansen LM, Talat N, Hill PC, Hussain R, Adegbola RA, Flynn J, Canfield D, Parsonnet J, , 2010. Infection with Helicobacter pylori is associated with protection against tuberculosis. PLoS ONE 5: e8804.[Crossref]
  17. Tian LG, Wang TP, Lv S, Wang FF, Guo J, Yin XM, Cai YC, Dickey MK, Steinmann P, Chen JX, , 2013. HIV and intestinal parasite co-infections among a Chinese population: an immunological profile. Infect Dis Poverty 2: 18.[Crossref]
  18. Chincha LO, Bernabé-Ortiz A, Samalvides CF, Soto AL, Gotuzzo HE, Terashima IA, , 2009. Infecciones parasitarias intestinales y factores asociados a la infección por coccidias en pacientes adultos de un hospital público de Lima, Perú. Rev Chilena Infectol 26: 440444.[Crossref]
  19. Boeke CE, Mora-Plazas M, Forero Y, Villamor E, , 2010. Intestinal protozoan infections in relation to nutritional status and gastrointestinal morbidity in Colombian school children. J Trop Pediatr 56: 299306.[Crossref]
  20. Tan KS, , 2008. New insights on classification, identification, and clinical relevance of Blastocystis spp. Clin Microbiol Rev 21: 639665.[Crossref]
  21. Perry S, Hussain R, Parsonnet J, , 2011. The impact of mucosal infections on acquisition and progression of tuberculosis. Mucosal Immunol 4: 246251.[Crossref]
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  • Received : 23 Jul 2013
  • Accepted : 24 Nov 2013

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