Volume 90, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Severe fever with thrombocytopenia syndrome (SFTS), which is caused by a novel bunyavirus, is an emerging infectious disease in China. In 2011, this new virus was designated as severe fever with thrombocytopenia syndrome virus (SFTSV). The aim of the present study was to determine the seroprevalence and risk factors of SFTSV infection. The investigation was conducted among the general population in Jiangsu Province, China in 2011. A total of 2,510 serum samples were collected. Testing by enzyme-linked immunosorbent assay was conducted to determine the seroprevalence of SFTSV infection. Result showed that the overall seroprevalence of SFTSV infection was 0.44% (11 of 2,510) in seven counties in Jiangsu Province. Multiple variable logistic regression analysis showed that raising goats, farming, and grazing were risk factors for SFTSV infection. Raising goats, farming, and grazing might be important risk factors for virus exposure, and appropriate health education could be useful in preventing infections.


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  1. Feldmann H, , 2011. Truly emerging: a new disease caused by a novel virus. N Engl J Med 364: 15611563.[Crossref]
  2. Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, Zhang L, Zhang QL, Popov VL, Li C, Qu J, Li Q, Zhang YP, Hai R, Wu W, Wang Q, Zhan FX, Wang XJ, Kan B, Wang SW, Wan KL, Jing HQ, Lu JX, Yin WW, Zhou H, Guan XH, Liu JF, Bi ZQ, Liu GH, Ren J, Wang H, Zhao Z, Song SD, He JR, Wan T, Zhang JS, Fu XP, Sun LN, Dong XP, Feng ZJ, Yang WZ, Hong T, Zhang Y, Walker DH, Wang Y, Li DX, , 2011. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364: 15231532.[Crossref]
  3. Xu BL, Liu LC, Huang XY, Ma H, Zhang Y, Du Y, Wang P, Tang X, Wang H, Kang K, Zhang S, Zhao G, Wu W, Yang Y, Chen H, Mu F, Chen W, , 2011. Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus. PLoS Pathog 7: e1002369.[Crossref]
  4. Chen H, Hu K, Zou J, Xiao J, , 2013. A cluster of cases of human-to-human transmission caused by severe fever with thrombocytopenia syndrome bunyavirus. Int J Infect Dis 17: e206e208.[Crossref]
  5. Zhao L, Zhai S, Wen H, Cui F, Chi Y, Wang L, Xue F, Wang Q, Wang Z, Zhang S, Song Y, Du J, Yu XJ, , 2012. Severe fever with thrombocytopenia syndrome virus, Shandong Province, China. Emerg Infect Dis 18: 963965.[Crossref]
  6. Bao CJ, Guo XL, Qi X, Hu JL, Zhou MH, Varma JK, Cui B, Yang HT, Jiao YJ, Klena JD, Li X, Tao WY, Li X, Chen Y, Zhu Z, Xu K, Shen AH, Wu T, Peng HY, Li ZF, Shan J, Shi ZY, Wang HJ, , 2011. A family cluster of infections by a newly recognized bunyavirus in eastern China, 2007: further evidence of person-to-person transmission. Clin Infect Dis 53: 12081214.[Crossref]
  7. Bao CJ, Qi X, Wang H, , 2011. A novel bunyavirus in China. N Engl J Med 365: 862863.[Crossref]
  8. Zhang YZ, Zhou DJ, Xiong Y, Chen XP, He YW, Sun Q, Yu B, Li J, Dai YA, Tian JH, Qin XC, Jin D, Cui Z, Luo XL, Li W, Lu S, Wang W, Peng JS, Guo WP, Li MH, Zhang S, Chen C, Wang Y, de Jong MD, Xu J, , 2011. Hemorrhagic fever caused by a novel tick-borne bunyavirus in Huaiyangshan, China. Chin J Epidemol 32: 209220.
  9. Ding F, Zhang W, Wang L, Hu W, Soares Maqalhaes RJ, Sun H, Zhou H, Sha S, Li S, Liu Q, Li Q, Yang W, Huang L, Li C, Yin W, , 2013. Epidemiologic features of severe fever with thrombocytopenia syndrome in China, 2011–2012. Clin Infect Dis 56: 16821693.[Crossref]
  10. Tang XY, Wu WL, Wang HF, Du YH, Liu LC, Kang K, Huang X, Ma H, Mu F, Zhang S, Zho G, Cui N, Zhu BP, You A, Chen H, Liu G, Chen W, Xu B, , 2013. Human-to-human transmission of severe fever with thrombocytopenia syndrome bunyavirus through contact with infectious blood. J Infect Dis 207: 736739.[Crossref]
  11. Jiao YJ, Zeng XY, Guo XL, Qi X, Zhang X, Shi ZY, Zhou M, Bao C, Zhang W, Xu Y, Wang H, , 2012. Preparation and evaluation of recombinant severe fever with thrombocytopenia syndrome virus nucleocapsid protein for detection of total antibodies in human and animal sera by double-antigen sandwich enzyme-linked immunosorbent assay. J Clin Microbiol 50: 372377.[Crossref]

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  • Received : 23 Jul 2013
  • Accepted : 01 Nov 2013

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