1921
Volume 90, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We conducted a longitudinal analysis of 117 lymphedema patients in a filariasis-endemic area of Haiti during 1995–2008. No difference in lymphedema progression between those who received or did not receive mass drug administration (MDA) was found on measures of foot ( = 0.24), ankle ( = 0.87), or leg ( = 0.46) circumference; leg volume displacement ( = 0.09), lymphedema stage ( = 0.93), or frequency of adenolymphangitis (ADL) episodes ( = 0.57). Rates of ADL per year were greater after initiation of MDA among both groups ( < 0.01). Nevertheless, patients who received MDA reported improvement in four areas of lymphedema-related quality of life ( ≤ 0.01). Decreases in foot and ankle circumference and ADL episodes were observed during the 1995-1998 lymphedema management study ( ≤ 0.01). This study represents the first longitudinal, quantitative, leg-specific analysis examining the clinical effect of diethylcarbamazine on lymphedema progression and ADL episodes.

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2014-01-08
2017-09-20
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  • Received : 03 Jun 2013
  • Accepted : 09 Oct 2013

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