1921
Volume 91, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Convergence of geographic regions endemic for human immunodeficiency virus (HIV) and cutaneous leishmaniasis (CL) raise concerns that HIV co-infection may worsen CL burden, complicating already lengthy and costly CL treatments and highlighting a need for newer therapies. We constructed two Markov decision models to quantify impact of HIV on CL and help establish a target product profile for new CL treatments, accounting for co-infection. The HIV co-infection increased lifetime cost per CL case 11–371 times ($1,349–45,683) that of HIV-negative individuals ($123) and Brazil's CL burden from $1.6–16.0 million to $1.6–65.5 million. A new treatment could be a cost saving at ≤ $254 across several ranges (treatments seeking probabilities, side effect risks, cure rates) and continues to save costs up to $508 across treatment-seeking probabilities with a drug cure rate of ≥ 50%. The HIV co-infection can increase CL burden, suggesting more joint HIV and CL surveillance and control efforts are needed.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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2014-09-03
2017-11-24
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References

  1. Gonzalez U, Pinart M, Rengifo-Pardo M, Macaya A, Alvar J, Tweed JA, , 2009. Interventions for American cutaneous and mucocutaneous leishmaniasis (Review). Cochrane Database Syst Rev 1170.
  2. Laguna F, , 2003. Treatment of leishmaniasis in HIV-positive patients. Ann Trop Med Parasitol 97: S135S142.[Crossref]
  3. Rabello A, Orsini M, Disch J, , 2003. Leishmania/HIV co-infection in Brazil: an appraisal. Ann Trop Med Parasitol 97: 1728.[Crossref]
  4. Bacon KM, Hotez PJ, Kruchten SD, Kamhawi S, Bottazzi ME, Valenzuela JG, Lee BY, , 2012. The potential economic value of a cutaneous leishmaniasis vaccine in seven endemic countries in the Americas. Vaccine 31: 480486.[Crossref]
  5. Alvar J, Velez ID, Bern C, Herrero M, Desjeux P, Cano J, Jannin J, den Boer M, , 2012. Leishmaniasis worldwide and global estimates of its incidence. PLoS ONE 7: e35671.[Crossref]
  6. Alvar J, Aparicio P, Aseffa A, Den Boer M, Canavate C, Dedet JP, Gradoni L, Ter Horst R, Lopez-Velez R, Moreno J, , 2008. The relationship between leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev 21: 334359.[Crossref]
  7. Guerra JA, Coelho LI, Pereira FR, Siqueira AM, Ribeiro RL, Almeida TM, Lacerda MV, Barbosa M, Talhari S, , 2011. American tegumentary leishmaniasis and HIV-AIDS association in a tertiary care center in the Brazilian Amazon. Am J Trop Med Hyg 85: 524527.[Crossref]
  8. Ferro C, Marin D, Gongora R, Carrasquilla MC, Trujillo JE, Rueda NK, Marin J, Valderrama-Ardila C, Alexander N, Perez M, Munstermann LE, Ocampo CB, , 2011. Phlebotomine vector ecology in the domestic transmission of American cutaneous leishmaniasis in Chaparral, Colombia. Am J Trop Med Hyg 85: 847856.[Crossref]
  9. Soto J, Valda-Rodriquez L, Toledo J, Vera-Navarro L, Luz M, Monasterios-Torrico H, Vega J, Berman J, , 2004. Comparison of generic to branded pentavalent antimony for treatment of new world cutaneous leishmaniasis. Am J Trop Med Hyg 71: 577581.
  10. Herwaldt BL, , 1999. Leishmaniasis. Lancet 354: 11911199.[Crossref]
  11. Desjeux P, , 1991. Information on the Epidemiology and Control of the Leishmaniases by Country or Territory. Geneva: World Health Organization, 47.
  12. Tuon FF, Amato VS, Graf ME, Siqueira AM, Nicodemo AC, Neto VA, , 2008. Treatment of new world cutaneous leishmaniasis: a systematic review with a meta-analysis. Int J Dermatol 47: 109124.[Crossref]
  13. Amato VS, Tuon FF, Siqueira AM, Nicodemo AC, Neto VA, , 2007. Treatment of mucosal leishmaniasis in Latin America: systematic review. Am J Trop Med Hyg 77: 266274.
  14. Zerpa O, Ulrich M, Blanco B, Polegre M, Avila A, Matos N, Mendoza I, Pratlong F, Ravel C, Convit J, , 2007. Diffuse cutaneous leishmaniasis responds to miltefosine but then relapses. Br J Dermatol 156: 13281335.[Crossref]
  15. WHO, 2010. Report of a meeting of the WHO Expert Committee on the control of leishmaniases, Geneva, 22–26 March 2010. Control of Leishmaniases. Geneva: World Health Organization.
  16. Mattos M, Caiza A, Fernandes O, Goncalves AJS, Pirmez C, Souza CSF, Oliveira-Neto MP, , 1998. American cutaneous leishmaniasis associated with HIV infection: report of four cases. J Eur Acad Dermatol 10: 218225.[Crossref]
  17. Soto J, Soto P, , 2006. Miltefosine: oral treatment of leishmaniasis. Expert Rev Anti Infect Ther 4: 177190.[Crossref]
  18. Vinson R, , 2010. Application for inclusion of Miltefosine on WHO Model List of Essential Medicines. Quebec, Canada: Paladin Labs, 21.
  19. Project Inform, 1998. The HIV Drug Book: Revised and Updated. Second edition. New York, NY: Pocket Books.
  20. Patthak A, Pien FD, Carvalho L, , 1998. Amphotericin B use in a community hospital with special emphasis on side effects. Clin Infect Dis 26: 334338.[Crossref]
  21. Vega JC, Sanchez BF, Montero LM, Montana R, del Pilar Mahecha M, Duenes B, Baron AR, Reithinger R, , 2007. Short communication: the cost-effectiveness of cutaneous leishmaniasis patient management during an epidemic in Chaparral, Columbia in 2004. Trop Med Int Health 12: 15401544.[Crossref]
  22. WHO, 2008. WHO-CHOICE: Choosing Interventions that are Cost Effective. Geneva: World Health Organization.
  23. Turetz ML, Machado PR, Ko AI, Alves F, Bittencourt A, Almeida RP, Mobashery N, Johnson WD, Carvalho EM, , 2002. Disseminated leishmaniasis: a new and emerging form of leishmaniasis observed in northeastern Brazil. J Infect Dis 186: 18291834.[Crossref]
  24. Shepard DS, Gold MR, Siegel JE, Russell LB, Weinstein MC, , 1999. Cost-effectiveness in Health and Medicine. , eds. New York: Oxford University Press, 1996. J Ment Health Policy Econ 2: 9192.
  25. World Health Organization, 2013. Global Health Observatory Data Repository, Life Expectancy: Life Tables Brazil. Available at: http://apps.who.int/gho/data/view.main.60220. Accessed December 15, 2012.
  26. Murray HW, Berman JD, Davies CR, Saravia NG, , 2005. Advances in leishmaniasis. Lancet 366: 15611577.[Crossref]
  27. David CV, Craft N, , 2009. Cutaneous and mucocutaneous leishmaniasis. Dermatol Ther 22: 491502.[Crossref]
  28. Sesso R, Barbosa da Silva C, Kowalski C, Mandredi SR, Canziani ME, Draibe SA, Elgazzar HA, Ferraz MB, , 2007. Dialysis care, cardiovascular disease, and costs in end-stage renal disease in Brazil. Int J Technol Assess 23: 126130.[Crossref]
  29. Rosenthal E, Marty P, Poizot-Martin I, Reynes J, Pratlong F, Lafeuillade A, Jaubert D, Boulat O, Dereure J, Gambarelli F, Gastaut JA, Dujardin P, Dellamonica P, Cassuto J, , 1995. Visceral leishmaniasis and HIV-1 co-infection in southern France. Trans R Soc Trop Med Hyg 89: 159162.[Crossref]
  30. Medrano FJ, Hernandez-Quero J, Jimenez E, Pineda JA, Rivero A, Sanchez-Quijano A, Velez ID, Viciana P, Castillo R, Reyes MJ, Carvajal F, Leal M, Lissen E, , 1992. Visceral leishmaniasis in HIV-1-infected individuals: a common opportunistic infection in Spain? AIDS 6: 14991503.[Crossref]
  31. Desjeax P, Alvar J, , 2003. Leishmania/HIV co-infections: epidemiology in Europe. Ann Trop Med Parasitol 97: S3S15.[Crossref]
  32. Markle WH, Makhoul K, , 2004. Cutaneous leishmaniasis: recognition and treatment. Am Fam Physician 69: 14551460.
  33. Haldar AK, Sen P, Roy S, , 2011. Use of antimony in the treatment of leishmaniasis: current status and future directions. Mol Biol Int 2011: 23.[Crossref]
  34. The World Bank, 2013. World Bank Data: Health expenditures, total (% of GDP). Switzerland: The World Bank.
  35. Jamison D, Breman J, Measham A, Alleyne G, Claeson M, Evans D, Jha P, Mills A, Musgrove P, , 2006. Disease Control Priorities in Developing Countries: The World Bank. Washington, DC: World Bank.[Crossref]
  36. Lee BY, , 2008. Digital decision making: computer models and antibiotic prescribing in the twenty-first century. Clin Infect Dis 46: 11391141.[Crossref]
  37. Lee BY, Biggerstaff BJ, , 2006. Screening the United States blood supply for West Nile Virus: a question of blood, dollars, and sense. PLoS Med 3: e99.[Crossref]
  38. Davidson RN, , 1998. Practical guide for the treatment of leishmaniasis. Drugs 56: 10091018.[Crossref]
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  • Received : 31 May 2013
  • Accepted : 18 Jan 2014

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