Volume 90, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Artesunate (AS) in combination with sulfadoxine/pyrimethamine (SP) is the first-line therapy for management of uncomplicated malaria in Sudan. The objective of this study was to assess the potential impact of SP on the pharmacokinetics of AS and its active metabolite, dihydroartemisinin (DHA), in healthy adults. A single-dose, randomized, open-label, crossover study design with a washout period of three weeks was performed with 16 volunteers. After oral administration of AS alone or in combination with SP, T values of AS and DHA were significantly prolonged in the combination group ( < 0.05). However, there was no significant effect on the other pharmacokinetic parameters ( > 0.05). The t values of AS and DHA were significantly higher in females than in males ( < 0.05). The present findings suggest that co-administration of SP with AS has no clinically relevant impact on the pharmacokinetics of AS or DHA in healthy persons.


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  • Received : 23 May 2013
  • Accepted : 06 Feb 2014
  • Published online : 04 Jun 2014

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