Volume 90, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We investigated the serum and urine chemokine levels of patients with schistosomal mansoni glomerulonephritis. This cross-sectional study was conducted in the Southeast of Brazil. Overall, 160 subjects were enrolled and divided into five groups: 1) hepatosplenic schistosomiasis with renal disease ( = 12); 2) hepatosplenic schistosomiasis without renal disease ( = 68); 3) hepatointestinal schistosomiasis ( = 27); 4) glomerulopathy caused by other diseases ( = 22); and 5) healthy controls ( = 31). The patients with microalbuminuria > 30 mg in 24 hours were considered to have renal disease. The sera and urine chemokines CCL2, CCL3, CCL5, CCL11, and CXCL8 were measured using an enzyme-linked immunosorbent assay test. A similar profile was observed between the patients with schistosomal glomerulopathy and the patients with glomerulopathy caused by other diseases, with the exception of serum CCL2 ≤ 634.3 pg/mL. In cases with sera CCL2 > 634.3 pg/mL, the diagnosis of schistosomal glomerulopathy should be considered.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Brasil, Ministério da Saúde.Secretaria de Vigilância em Saúde, 2010. Situação epidemiológica de Esquistossomose no Brasil. Grupo Técnico das Parasitárias, Sub HA/CGDT/DEVEP/SVS/MS Brasília. Available at: http://portal.saude.gov.br/portal/arquivos/pdf/situacao_esquistossomose_brasil_abril2011.pdf. Acessado em junho de 2013.
  2. Hoffman DB, Lehman JS, Scott VC, Warren KS, Webbe G, , 1979.Control of schistosomiasis: report of a workshop. Am J Trop Med Hyg 28: 249259. [Google Scholar]
  3. Lambertucci JR, Jordan P, Webbe G, Sturrock RF, , 1993. Schistosoma mansoni: pathological and clinical aspects. , eds. Human Schistosomiasis. Wallingford: Cab International, 195225. [Google Scholar]
  4. Lambertucci JR, dos Santos Silva LC, Andrade LM, de Queiroz LC, Carvalho VT, Voieta I, Antunes CM, , 2008. Imaging techniques in the evaluation of morbidity in schistosomiasis mansoni. Acta Trop 108: 209217.[Crossref] [Google Scholar]
  5. Rodrigues VL, Otoni A, Voieta I, Antunes CM, Lambertucci JR, , 2010. Glomerulonephritis in schistosomiasis mansoni: a time to reappraise. Rev Soc Bras Med Trop Nov-Dec 43: 638642.[Crossref] [Google Scholar]
  6. Lambertucci JR, Otoni A, dos Reis MA, , 2007. Nephrotic syndrome in hepatosplenic schistosomiasis mansoni. Rev Soc Bras Med Trop 40: 492493.[Crossref] [Google Scholar]
  7. Lambertucci JR, Serufo JC, Gerspacher-Lara R, Rayes AA, Teixeira R, Nobre V, Antunes CM, , 2000. Schistosoma mansoni: assessment of morbidity before and after control. Acta Trop 77: 101109.[Crossref] [Google Scholar]
  8. Hawkins R, , 2011. New biomarkers of acute kidney injury and the cardio-renal syndrome. Korean J Lab Med 31: 7280.[Crossref] [Google Scholar]
  9. Araya CE, Wasserfall CH, Brusko TM, Mu W, Segal MS, Johnson RJ, Garin EH, , 2006. A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome. Pediatr Nephrol 21: 603610.[Crossref] [Google Scholar]
  10. Garin EH, , 2000. Circulating mediators of proteinuria in idiopathic minimal lesion nephrotic syndrome. Pediatric Nephrol 14: 872878.[Crossref] [Google Scholar]
  11. Souto MF, Teixeira AL, Russo RC, Penido MG, Silveira KD, Teixeira MM, Simões E, Silva AC, , 2008. Immune mediators in idiopathic nephrotic syndrome: evidence for a relation between interleukin 8 and proteinuria. Pediatr Res 64: 637642.[Crossref] [Google Scholar]
  12. Vaidya VS, Niewczas MA, Ficociello LH, Johnson AC, Collings FB, Warram JH, Krolewski AS, Bonventre JV, , 2011. Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-beta-D-glucosaminidase. Kidney Inter 79: 464470.[Crossref] [Google Scholar]
  13. Ibrahim S, Rashed L, , 2008. Correlation of urinary monocyte chemo-attractant protein-1 with other parameters of renal injury in type-II diabetes mellitus. Saudi J Kidney Dis Transpl 19: 911917. [Google Scholar]
  14. Mukaida N, Harada A, Matsushima K, , 1998. Interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF/MCP-1), chemokines essentially involved in inflammatory and immune reactions. Cytokine Growth Factor. Rev Mar 9: 923. [Google Scholar]
  15. Segerer S, , 2003. The role of chemokines and chemokine receptors in progressive renal diseases. American J Kidney Dis 41 (Suppl 1): S15S18.[Crossref] [Google Scholar]
  16. Sun Y, Yuan S, Xu X, , 2009. Expression of MCP-1 in renal tissues of patients with IgA nephropathy. Zhong Nan Da Xue Xue Bao Yi Xue Ban 34: 10231028. [Google Scholar]
  17. Silva LC, Andrade LM, de Paula IB, de Queiroz LC, Antunes CM, Lambertucci JR, , 2012. Ultrasound and magnetic resonance imaging findings in Schistosomiasis mansoni: expanded gallbladder fossa and fatty hilum signs. Rev Soc Bras Med Trop Jul-Aug 45: 500504.[Crossref] [Google Scholar]
  18. Lambertucci JR, Godoy P, Neves J, Bambirra EA, Ferreira MD, , 1988. Glomerulonephritis in Salmonella-Schistosoma-mansoni association. Am J Trop Med Hyg 38: 97102. [Google Scholar]
  19. Katz N, Chaves A, Pellegrino J, , 1972. A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Rev Inst Med Trop São Paulo 14: 397400. [Google Scholar]
  20. Nyman HA, Dowling TC, Hudson JQ, Peter WL, Joy MS, Nolin TD, , 2011. Comparative evaluation of the Cockcroft-Gault Equation and the Modification of Diet in Renal Disease (MDRD) study equation for drug dosing: an opinion of the Nephrology Practice and Research Network of the American College of Clinical Pharmacy. Pharmacotherapy 31: 11301144.[Crossref] [Google Scholar]
  21. Grupo de Trabalho MA, , 2011. Brazilian guidelines for ambulatory monitoring of arterial pressure and III Brazilian guidelines for home monitoring of blood pressure. J Bras Nefrol Jul-Sep 33: 365388.[Crossref] [Google Scholar]
  22. Bewick V, Cheek L, Ball J, , 2005. Statistics review 14: logistic regression. Crit Care 9: 112118.[Crossref] [Google Scholar]
  23. Stiglic G, Kocbek S, Pernek I, Kokol P, , 2012. Comprehensive decision tree models in bioinformatics. PLoS ONE 7: e33812.[Crossref] [Google Scholar]
  24. Biau G, , 2012. Analysis of a random forests model. J Mach Learn Res 13: 10631095. [Google Scholar]
  25. Loh WY, Shih YS, , 1997. Split selection methods for classification trees. Statist Sinica 7: 815840. [Google Scholar]
  26. Daniel C, Schaub K, Amann K, Lawler J, Hugo C, , 2007. Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in vivo . Diabetes 56: 29822989.[Crossref] [Google Scholar]
  27. Sanchez-Niño MD, Sanz AB, Ihalmo P, Lassila M, Holthofer H, Mezzano S, Aros C, Groop PH, Saleem MA, Mathieson PW, Langham R, Kretzler M, Nair V, Lemley KV, Nelson RG, Mervaala E, Mattinzoli D, Rastaldi MP, Ruiz-Ortega M, Martin-Ventura JL, Egido J, Ortiz A, , 2009. The MIF receptor CD74 in diabetic podocyte injury. J Am Soc Nephrol 20: 353362.[Crossref] [Google Scholar]
  28. Hsing CH, Hsu CC, Chen WY, Chang LY, Hwang JC, Chang MS, , 2007. Expression of IL-19 correlates with Th2 cytokines in uraemic patients. Nephrol Dial Transplant 22: 22302238.[Crossref] [Google Scholar]
  29. Tesch GH, , 2008. MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy. Am J of Physiol Renal Physiol 294: F697F701.[Crossref] [Google Scholar]
  30. Chow FY, Nikolic-Paterson DJ, Ozols E, Atkins RC, Rollin BJ, Tesch GH, , 2006. Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice. Kidney Int 69: 7380.[Crossref] [Google Scholar]
  31. Wu H, Wang Y, Tay YC, Zheng G, Zhang C, Alexander SI, Harris DC, , 2005. DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. Kidney Int 67: 21782186.[Crossref] [Google Scholar]
  32. Vielhauer V, Berning E, Eis V, Kretzler M, Segerer S, Strutz F, Horuk R, Gröne HJ, Schlöndorff D, Anders HJ, , 2004. CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome. Kidney Int 66: 22642278.[Crossref] [Google Scholar]
  33. Sousa-Pereira SR, Teixeira AL, Silva LC, Souza AL, Antunes CM, Teixeira MM, Lambertucci JR, , 2006. Serum and cerebral spinal fluid levels of chemokines and Th2 cytokines in Schistosoma mansoni myeloradiculopathy. Parasite Immunol 28: 473478.[Crossref] [Google Scholar]
  34. Cherney DZ, Scholey JW, Sochett E, Bradley TJ, Reich HN, , 2011. The acute effect of clamped hyperglycemia on the urinary excretion of inflammatory cytokines/chemokines in uncomplicated type 1 diabetes. Diabetes Care 34: 177180.[Crossref] [Google Scholar]
  35. Wolkow PP, Niewczas MA, Perkins B, Ficociello LH, Lipinski B, Warram JH, Krolewski AS, , 2008. Association of urinary inflammatory markers and renal decline in microalbuminuric type 1 diabetics. J Am Soc Nephrol 19: 789797.[Crossref] [Google Scholar]
  36. Takebayashi K, Matsumoto S, Aso Y, Inukai T, , 2006. Association between circulating monocyte chemoattractant protein-1 and urinary albumin excretion in nonobese Type 2 diabetic patients. J Diabetes Complications 20: 98104.[Crossref] [Google Scholar]
  37. Amann B, Tinzmann R, Angelkort B, , 2003. ACE inhibitors improve diabetic nephropathy through suppression of renal MCP-1. Diabetes Care 26: 24212425.[Crossref] [Google Scholar]

Data & Media loading...

  • Received : 19 May 2013
  • Accepted : 18 Sep 2013
  • Published online : 08 Jan 2014

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error